PubMed-compiled information sheet
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Compiled from 12 PubMed articles · model: gemma4:31b
Summary
Artemisia lactiflora, also known as white mugwort, is a traditional Chinese medicinal plant recognized for its antioxidant and anti-inflammatory properties [PMID:38439740, PMID:36900469].
Background
Artemisia lactiflora (white mugwort) is a plant of Chinese origin used in traditional medicine [PMID:34939447, PMID:36900469].
Traditional uses
It is used in traditional Chinese medicine for the treatment of hepatic and menstrual disorders [PMID:38439740].
Active compounds
The plant contains polyphenols, including morin [PMID:24858497, PMID:36900469]. Isolated compounds from alcohol extracts include 7-hydroxycoumarin, 7-methoxycoumarin, balanophonin, aurantiamide, aurantiamide acetate, isovitexin, kaempferol-3-O-beta-D-rutinoside, rutin, caffeic acid ethyl ester, quercetin, and methyl 3, 5-di-O-caffeoyl quinate and methyl 3, 4-di-O-caffeoyl quinate [PMID:25276977]. Diethyl ether extracts have been found to contain terpenoids such as dihydroactinidiolide, megastigmatrienone, alpha-curcumene, and dehydrovomifoliol [PMID:38439740]. Additionally, a diacetylenic spiroketal enol ether epoxide known as AL-1 has been identified [PMID:10403539].
Mechanism of action
Extracts may prevent inflammatory responses in human macrophages stimulated by charcoal pyrolysis smoke [PMID:34939447]. The compound AL-1 may inhibit tumor promotion by suppressing oxidative stress and inhibiting O2- generation and H2O2 production [PMID:10403539]. Diethyl ether extracts and dihydroactinidiolide have been shown to downregulate mesenchymal N-cadherin in non-small cell lung cancer (NSCLC) cells, thereby inhibiting migration and invasion [PMID:38439740].
Clinical evidence
Evidence DInflammation (In vitro)
Extracts prevented inflammatory responses in human macrophages stimulated with charcoal pyrolysis smoke [PMID:34939447]
Evidence DLung Cancer Metastasis (In vitro)
Diethyl ether extract (32 μg/ml) and dihydroactinidiolide (250 μg/ml) inhibited migration and invasion of non-small cell lung cancer cells [PMID:38439740]
Evidence DTumor Promotion (Animal/In vitro)
AL-1 suppressed TPA-induced H2O2 generation in mouse skin and inhibited EBV activation in Raji cells [PMID:10403539]
Evidence summary
The current evidence is limited to in vitro studies and animal models (Level D), focusing primarily on phytochemical characterization, antioxidant activity, and preliminary anti-inflammatory and anti-metastatic effects.
PubMed sources
- 1.PMID: 34939447 (2021) — Artemisia lactiflora Extracts Prevent Inflammatory Responses of Human Macrophages Stimulated with Charcoal Pyrolysis Smoke. · Journal of evidence-based integrative medicine
- 2.PMID: 39335871 (2024) — Interactions of White Mugwort (Artemisia lactiflora Wall.) Extract with Food Ingredients during In Vitro Gastrointestinal Digestion and Their Impact on Bioaccessibility of Polyphenols in Various Model Systems. · Foods (Basel, Switzerland)
- 3.PMID: 36900469 (2023) — Assessment of Polyphenols Bioaccessibility, Stability, and Antioxidant Activity of White Mugwort (Artemisia lactiflora Wall.) during Static In Vitro Gastrointestinal Digestion. · Foods (Basel, Switzerland)
- 4.PMID: 24858497 (2014) — Antioxidant activity in extracts of 27 indigenous Taiwanese vegetables. · Nutrients
- 5.PMID: 38439740