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Withania somnifera
This herb is NOT recommended during pregnancy due to potential risks to the developing fetus.
This herb is NOT recommended while breastfeeding as effects on infants are unknown.
Consult your healthcare provider before use.
This herb may interact with medications you are taking. Review the interactions table below and consult your healthcare provider before use.
Ashwagandha is a revered herb in Ayurvedic medicine, used for over 3,000 years as a rasayana (rejuvenating tonic). It is classified as an adaptogen, helping the body manage stress and maintain homeostasis. Modern research supports its use for anxiety, stress, and physical performance.
Ashwagandha (Withania somnifera) is the flagship adaptogen in Ayurvedic medicine, with strong clinical evidence for stress reduction and anxiolysis. KSM-66® and Sensoril® extracts have the most robust trial data, showing cortisol reduction of 14.5-30% and significant improvements in perceived stress scales.
Withanolides (particularly withaferin A and withanolide D) modulate GABA-A receptors, reduce cortisol via HPA axis regulation, and activate Nrf2 antioxidant pathways. Root extracts (KSM-66) favor anxiolytic effects while leaf extracts (Sensoril) favor stress/adaptogenic effects.
Stress and anxiety reduction
Multiple RCTs with KSM-66 showing significant cortisol reduction
Sleep quality improvement
RCTs show improved sleep onset latency and quality
Testosterone and fertility in men
RCTs show 10-17% increase in testosterone in healthy men
Athletic performance
RCTs show improved VO2 max and strength; some studies conflict
Thyroid function support
Small studies suggest T3/T4 normalization in subclinical hypothyroidism
Cognitive enhancement
Preliminary evidence for memory; more trials needed
| Drug | Severity | Description |
|---|---|---|
| Immunosuppressants (general) | Moderate | Ashwagandha has immune-stimulating properties that may counteract the effects of immunosuppressive medications. |
| Levothyroxine (Synthroid) | Moderate | Ashwagandha may increase thyroid hormone production, potentially causing excessive thyroid levels in patients taking thyroid medication. |
| Benzodiazepines (general) | Moderate | Ashwagandha may enhance the sedative effects of benzodiazepines, increasing drowsiness. |
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