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AB
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Asteraceae Blessed Thistle
Cnicus benedictus
digestive bitter tonic in medieval European medicine
PubMed · Cnicus benedictus: Folk Medicinal Uses, Biological Activities, and In Silico Screening of Main Phytochemical Constituents. (2024)
PubMed · <i>Cnicus benedictus</i> extract-loaded electrospun gelatin wound dressing for treating diabetic wounds: An in vitro and in vivo study. (2024)
Reviewed by: HerbAlly Editorial Team, Medical herbalists and healthcare professionals
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 29 PubMed articles · model: gemma4:31b
Summary
Blessed Thistle (Cnicus benedictus) is a medicinal herb containing sesquiterpene lactones and phenolics, traditionally used for various ailments and currently researched for regenerative and antiproliferative properties [PMID:30000834, PMID:39265629].
Background
Cnicus benedictus (also known as Centaurea benedicta or Carduus benedictus) is a member of the Asteraceae (ragweed) family [PMID:30000834, PMID:39771277].
Traditional uses
Traditional medicine has recognized its therapeutic potential, including use for stomachache pain, as an appetite stimulant, and for effects on the liver and bile secretion [PMID:33628288, PMID:39771277]. It is also a purported galactogogue used to increase milk supply [PMID:30000834].
Active compounds
The plant contains sesquiterpene lactones (including cnicin, arctigenin, and arctiin), triterpenoids, lignans, tannins, essential oils, flavonoids, and polyenes [PMID:30000834, PMID:39265629]. Phenolic compounds found in the roots include trans chalcone, 2,3-dihydro flavone, 3-hydroxy flavone, cinnamic acid, and rutin [PMID:37997548]. Other identified constituents include chlorogenic acid, sinapic acid, and various hydroxycinnamates [PMID:30993111, PMID:21453943].
Mechanism of action
Cnicin may promote axon regeneration by interacting with vasohibin [PMID:38718639]. Leaf extracts have demonstrated anti-nociceptive effects potentially involving the L-arginine/nitric oxide/cGMP/ATP-sensitive potassium channel pathway (LNCaP) and opioid mechanisms [PMID:33628288]. Extract-loaded dressings in diabetic wounds upregulated VEGF and IGF gene expression [PMID:38733215].
Clinical evidence
Evidence CLactation/Milk Supply
Purported use as a galactogogue; however, no scientifically valid clinical trials support this use [PMID:30000834].
Evidence DNerve Regeneration
Cnicin promotes axon growth of sensory and CNS neurons (including humans) in culture and accelerates functional regeneration via intravenous administration in studies [PMID:38718639].
Evidence DDiabetic Wounds
Cnicus benedictus extract-loaded gelatin scaffolds significantly increased wound size reduction, collagen deposition, and epithelial thickness in a rat model [PMID:38733215].
Evidence DCervical Cancer
Methanolic leaf extract (CBHE) inhibited the growth of Hela cancer cells in vitro in a concentration- and time-dependent manner [PMID:39471032].
Evidence DPain (Antinociception)
Leaf methanolic extract (CBHE) exhibited anti-nociceptive effects in writhing, tail-flick, and formalin-induced paw licking tests in animal models [PMID:33628288].
Evidence D
Safety & adverse effects
The herb is 'generally recognized as safe' (GRAS) as a flavoring in alcoholic beverages by the FDA [PMID:30000834]. However, because it is in the ragweed family, allergy is a concern; high doses reportedly cause nausea, vomiting, and stomach cramps [PMID:30000834]. One case of elevated liver enzymes was reported in a woman using a tea containing blessed thistle and other ingredients [PMID:30000834]. A historical account describes a fatal case of excruciating chest pain following the use of an extract and attempted vomiting [PMID:23343736].
Pregnancy & lactation
Used as a purported galactogogue to increase milk supply, though clinical evidence is lacking [PMID:30000834].
Evidence summary
The majority of evidence is derived from in vitro studies and animal models (Level D), with some review-level data (Level C) regarding its use as a galactogogue. There are no high-level clinical trials (Level A or B) provided in the abstracts.
PubMed sources
1.PMID: 30000834 (2006) — Adverse effects of herbal medicines: an overview of systematic reviews. · Clinical medicine (London, England)
2.PMID: 38718639 (2024) — Cnicin promotes functional nerve regeneration. · Phytomedicine : international journal of phytotherapy and phytopharmacology
3.PMID: 11365626 (1998) — Essiac for cancer? · TreatmentUpdate
4.PMID: 38733215 (2024) — Cnicus benedictus extract-loaded electrospun gelatin wound dressing for treating diabetic wounds: An in vitro and in vivo study. · Journal of applied biomaterials & functional materials
5.PMID: 39265629 (2024) — Cnicus benedictus: Folk Medicinal Uses, Biological Activities, and In Silico Screening of Main Phytochemical Constituents.
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
A polyphenol-enriched n-butanol fraction was investigated for hepatoprotective effects against carbon tetrachloride-induced liver fibrosis in rats [PMID:39758800].
· Planta medica
6.PMID: 28287272 (2017) — Two new sesquiterpene lactone glycosides from Cnicus benedictus. · Natural product research
7.PMID: 39471032 (2024) — In Vitro Evaluate the Antiproliferative Impact of Cnicus Benedictus L. Leaves Methanolic Extract on Cervical Cancer. · Asian Pacific journal of cancer prevention : APJCP
8.PMID: 37997548 (2024) — HPLC/ESI-MS Characterization of Phenolic Compounds from Cnicus benedictus L. Roots: A Study of Antioxidant, Antibacterial, Anti-Inflammatory, and Anti-Alzheimer's Activity. · Chemistry & biodiversity
9.PMID: 23012383 (2012) — The use of galactogogues in the breastfeeding mother. · The Annals of pharmacotherapy
10.PMID: 33628288 (2020) — Antinociceptive activity of Cnicus benedictus L. leaf extract: a mechanistic evaluation. · Research in pharmaceutical sciences
11.PMID: 22557343 (2009) — In vitro antioxidant activities of Asteraceae Plants. · Ancient science of life
12.PMID: 23343736 (2013) — [Boerhaave and his syndrome]. · Nederlands tijdschrift voor geneeskunde
13.PMID: 35533533 (2022) — Simultaneous determination and characterization of flavonoids, sesquiterpene lactone, and other phenolics from Centaurea benedicta and dietary supplements using UHPLC-PDA-MS and LC-DAD-QToF. · Journal of pharmaceutical and biomedical analysis
14.PMID: 34685825 (2021) — Free Radical Scavenging Activity of Infusions of Different Medicinal Plants for Use in Obstetrics. · Plants (Basel, Switzerland)
15.PMID: 22557338 (2009) — In vitro anti-tumour studies on Cnicus wallichi DC. · Ancient science of life
16.PMID: 30993111 (2019) — Chemical and Bioactivity Evaluation of Eryngium planum and Cnicus benedictus Polyphenolic-Rich Extracts. · BioMed research international
17.PMID: 26109755 (2015) — Inhibitory potential of some Romanian medicinal plants against enzymes linked to neurodegenerative diseases and their antioxidant activity. · Pharmacognosy magazine
18.PMID: 39758800 (2025) — The hepatoprotective effects of the polyphenol-enriched n-butanol fraction of Cnicus benedictus against carbon tetrachloride-induced liver fibrosis in rats: In vivo study. · Toxicology reports
19.PMID: 39771277 (2024) — Centaurea benedicta-A Potential Source of Nutrients and Bioactive Components. · Plants (Basel, Switzerland)
20.PMID: 19609882 (2009) — Characterisation of phenolics in Flor-Essence--a compound herbal product and its contributing herbs. · Phytochemical analysis : PCA
21.PMID: 33164156 (2021) — In vitro and in vivo evaluation of cnicin from blessed thistle (Centaurea benedicta) and its inclusion complexes with cyclodextrins against Schistosoma mansoni. · Parasitology research
22.PMID: 35780286 (2022) — Antioxidant Activity and Profile of Phenolic Compounds in Selected Herbal Plants. · Plant foods for human nutrition (Dordrecht, Netherlands)
23.PMID: 21453943 (2011) — Determination of the hydroxycinnamate profile of 12 members of the Asteraceae family. · Phytochemistry