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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Bletilla striata (Bai Ji) is a traditional Chinese medicinal herb known for its hemostatic, anti-inflammatory, and wound-healing properties [PMID:27865796, PMID:37898246].
Background
Bletilla striata (Thunb.) Reichb. f., also known as Hyacinth Orchid or Baiji, is a perennial plant from the Orchidaceae family [PMID:27865796, PMID:28276764].
Traditional uses
Traditionally used for the treatment of hematemesis, hemoptysis, traumatic bleeding, tuberculosis, pneumonophthisis, pneumonorrhagia, and hemorrhage of the stomach or lung [PMID:27865796, PMID:28276764]. It is also applied topically for ulcers, sores, swellings, chapped skin, hemorrhoids, anthrax, and eye diseases [PMID:27865796].
Active compounds
The herb contains Bletilla striata polysaccharides (BSP), a linear β-(1→4)-glucomannan composed of mannose and glucose [PMID:41116515, PMID:42197196]. Other identified compounds include approximately 158 to 294 constituents, such as glucosides, bibenzyls, phenanthrenes, quinones, biphenanthrenes, dihydrophenanthrenes, anthocyanins, steroids, triterpenoids, phenolic acids, neolignan glycosides, and stilbenoids [PMID:31736742, PMID:40645542, PMID:37757922, PMID:30585518].
Mechanism of action
BSP alleviates ARDS by inhibiting NETs-induced pyroptosis in pulmonary alveolar macrophages via the PAD4 pathway [PMID:39954881]. In skin damage, it activates the Nrf2/HO-1 signaling pathway and suppresses ferroptosis by upregulating GPX4 and FTH1 [PMID:41116515]. It also inhibits the TNF-α/NF-κB pathway and upregulates IL-10 for anti-inflammatory effects [PMID:40368564]. In liver disease, it modulates the NLRP3/caspase-1/GSDMD signaling pathway [PMID:40626309] and enhances hepatocyte RelA/HNF1α signaling [PMID:39877717]. Gymconopin C regulates the miR-6777-5p/ADRB2 pathway to promote mitophagy in lung cancer cells [PMID:41423048].
Clinical evidence
Evidence CPeptic Ulcer
Demonstrated notable clinical efficacy as a mucosa-protective agent [PMID:40904885, PMID:31736742]
Evidence DWound Healing
BSP-based hydrogels and sponges accelerate wound healing and exhibit high biocompatibility [PMID:31582069, PMID:36484704, PMID:32919631]
BSP ameliorates liver injury and lipid deposition by decreasing NLRP3 inflammasome and enhancing RelA/HNF1α signaling [PMID:40626309, PMID:39877717]
Evidence DAndrogenetic Alopecia (AGA)
BSP improved hair growth cycle and follicle morphology in mice by inhibiting PTGS2 [PMID:41519340]
Safety & adverse effects
BSP is described as having bio-safety and excellent biocompatibility [PMID:37898246, PMID:41116515].
Evidence summary
The evidence consists primarily of in vitro studies and animal models (Level D) and literature reviews (Level C), focusing on the pharmacological activities of Bletilla striata polysaccharides (BSP) and isolated phytochemicals.
PubMed sources
1.PMID: 39954881 (2025) — Bletilla striata polysaccharides alleviate ARDS by inhibiting NETs-induced pyroptosis in pulmonary alveolar macrophage through the PAD4 pathway. · International journal of biological macromolecules
2.PMID: 28276764 (2017) — Phenolic compounds from Bletilla striata. · Journal of Asian natural products research
3.PMID: 38686688 (2024) — A Multifunctional Herb-Derived Glycopeptide Hydrogel for Chronic Wound Healing. · Small (Weinheim an der Bergstrasse, Germany)
4.PMID: 27865796 (2017) — Bletilla striata: Medicinal uses, phytochemistry and pharmacological activities. · Journal of ethnopharmacology
5.PMID: 41116515 (2025) — Bletilla striata polysaccharide protects against UVA-induced skin damage by activating Nrf2/HO-1 signaling and inhibiting ferroptosis.
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
7.PMID: 38911867 (2024) — Bletilla striata polysaccharide-coated andrographolide nanomicelles for targeted drug delivery to enhance anti-colon cancer efficacy. · Frontiers in immunology
8.PMID: 31168226 (2019) — Bletilla striata: a review of seedling propagation and cultivation modes. · Physiology and molecular biology of plants : an international journal of functional plant biology
9.PMID: 40846937 (2025) — Natural multi-active nanoparticles integrated biological hydrogel microcarriers for wound healing. · Journal of nanobiotechnology
10.PMID: 40904885 (2025) — Clinical efficacy and mechanism of Bletilla striata and Chinese herbal compounds in treatment of peptic ulcer. · World journal of gastroenterology
11.PMID: 41074163 (2025) — Bletilla striata polysaccharide microneedles with astragaloside Ⅳ loaded ZIF-8 nanoparticles for wound healing and anti-scar treatment. · Journal of nanobiotechnology
12.PMID: 31736742 (2019) — Chemical Constituents, Pharmacologic Properties, and Clinical Applications of Bletilla striata. · Frontiers in pharmacology
13.PMID: 37898246 (2024) — Dual properties of pharmacological activities and preparation excipient: Bletilla striata polysaccharides. · International journal of biological macromolecules
14.PMID: 40645542 (2025) — A comprehensive review of ethnopharmacology, phytochemistry, pharmacological effects, and quality control of Bletilla striata. · Journal of ethnopharmacology
15.PMID: 30612468 (2019) — Chemical constituents of Bletilla striata. · Journal of Asian natural products research
16.PMID: 41423048 (2025) — Gymconopin C exhibits anti-non-small cell lung cancer effect by regulating miR-6777-5p/ADRB2 pathway to promote mitophagy. · Journal of advanced research
17.PMID: 42197196 (2026) — Bletilla striata Polysaccharide: Structural Characteristics, Chemical Modification Strategies, and Dual-Field Application Progress in Biomedicine and the Food Industry. · Molecules (Basel, Switzerland)
19.PMID: 31270609 (2019) — Fusarium oxysporum KB-3 from Bletilla striata: an orchid mycorrhizal fungus. · Mycorrhiza
20.PMID: 40626309 (2025) — Bletilla striata polysaccharides ameliorate metabolic-associated fatty liver disease by decreasing the NLRP3 inflammasome and pyroptosis. · Frontiers in pharmacology
21.PMID: 39657486 (2025) — The synergistic gelation of novel Bletilla striata polysaccharide with hyaluronic acid: Characterization, rheology. · Food chemistry
22.PMID: 39877717 (2025) — Bletilla striata polysaccharides alleviate metabolic dysfunction-associated steatotic liver disease through enhancing hepatocyte RelA/ HNF1α signaling. · World journal of gastroenterology
23.PMID: 37838114 (2023) — Bletilla Striata polysaccharides thermosensitive gel for photothermal treatment of bacterial infection. · International journal of biological macromolecules
24.PMID: 36484704 (2023) — Bletilla striata polysaccharide - waterborne polyurethane hydrogel as a wound dressing. · Journal of biomaterials science. Polymer edition
25.PMID: 37757922 (2023) — Neuroprotective neolignan glycosides from the pseudobulbs of Bletilla striata. · Fitoterapia
26.PMID: 30585518 (2019) — Two new stilbenoids from Bletilla striata. · Journal of Asian natural products research
27.PMID: 35785503 (2022) — Haplotype-resolved genome assembly of Bletilla striata (Thunb.) Reichb.f. to elucidate medicinal value. · The Plant journal : for cell and molecular biology
28.PMID: 37740591 (2024) — Bioactive phytochemicals from the tubers of Bletilla striata Rchb.f. · Natural product research
29.PMID: 31582069 (2019) — Biocompatible and degradable Bletilla striata polysaccharide hemostasis sponges constructed from natural medicinal herb Bletilla striata. · Carbohydrate polymers
30.PMID: 41519340 (2026) — Bletilla striata polysaccharide (BSP) promotes hair growth and suppresses oxidative stress and senescence of dermal papilla cells by inhibiting prostaglandin-endoperoxide synthase 2 (PTGS2). · International journal of biological macromolecules