PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Bhumyamalaki Churna (3g twice daily) combined with Atibala was studied in 33 patients to assess sensory perception and symptoms like numbness and pain [PMID:22529650].
As part of an Ayurvedic formulation including Gokshuradi Guggulu and Vasa, it contributed to a significant reduction in serum creatinine, blood urea, and urinary albumin excretion in patients [PMID:22131758].
Leaf extracts restored deranged biochemical parameters in rat models of CCl4 and rifampicin-induced hepatic and renal assault [PMID:33364479].
Oral administration decreased the progression of FMuLv-induced erythroleukemia and enhanced the life span of mice [PMID:19815595].
Leaf extracts mitigated the increase of ACE, arginase, AChE, ADA, and LDH activities and MDA levels in doxorubicin-stressed rats [PMID:31823659].
Evidence summary
PubMed sources
- 1.PMID: 38642916 (2025) — Phytochemical profile and hepatoprotective potentiality of Phyllanthus genus: a review. · The Journal of pharmacy and pharmacology
- 2.PMID: 22529650 (2011) — Effect of Atibalamula and Bhumyamalaki on thirty-three patients of diabetic neuropathy. · Ayu
- 3.PMID: 22408311 (2011) — Pharmacognostic evaluation of leaves of certain Phyllanthus species used as a botanical source of Bhumyamalaki in Ayurveda. · Ayu
- 4.PMID: 38315581 (2025) — Identification of authentic Phyllanthus amarus species in India. · Natural product research
- 5.PMID: 31823659 (2022) — Modulatory effects of stonebreaker (Phyllanthus amarus) and bitter gourd (Momordica charantia) on enzymes linked with cardiac function in heart tissue of doxorubicin-stressed rats.