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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Bidens tripartita, also known as Three-lobe Beggarticks or bur marigold, is a flowering plant used in traditional medicine for its anti-inflammatory, antioxidant, and antimicrobial properties [PMID:24502053, PMID:23700917].
Background
Bidens tripartita is a flowering plant in the genus Bidens, family Compositae (Asteraceae), subfamily Asteroideae [PMID:24502053, PMID:23700917]. It is a European native species often found on riverbanks and in karst regions [PMID:40442159, PMID:35615141].
Traditional uses
Traditionally, it has been used as a remedy for chronic dysentery [PMID:30275354], scours [PMID:11639707], and for its antiseptic, anti-inflammatory, antioxidant, astringent, diuretic, febrifuge, narcotic, and sedative effects [PMID:24502053]. It is also used in some countries for its antidiabetic properties [PMID:27872708].
The plant exhibits radical scavenging activity via its flavonoids [PMID:18540165]. Some extracts demonstrate inhibitory activity against alpha-amylase and alpha-glucosidase [PMID:29217268]. It also acts as a quorum sensing (QS) agonist by mimicking acyl-homoserine lactone [PMID:24914718].
Clinical evidence
Evidence DInflammation
Aqueous infusion significantly reduced carrageenan-induced acute paw edema in rats and showed analgesic and antipyretic properties [PMID:19748256].
Evidence DDiabetes/Hyperglycemia
Ethyl acetate and n-butanol sub-extracts showed potent antidiabetic and hypoglycemic activity in normal and streptozotocin-induced diabetic rats [PMID:27872708].
Evidence DBacterial Pathologies (Fish)
Herbal infusions showed a positive vulnerary effect, eliminating infection and promoting wound healing in sturgeon [PMID:33935397].
Evidence DMicrobial Infections
Extracts showed antimicrobial activity against various Gram-positive and Gram-negative bacteria, while essential oils exhibited strong antifungal activity [PMID:19056546, PMID:21370967].
Safety & adverse effects
Acute toxicity was assessed in mice using the median lethal dose (LD50) calculation via a limit dose test [PMID:23700917]. Essential oil was tested for biocompatibility on human dermal fibroblasts using MTT and COMET assays to exclude toxic effects [PMID:30275354].
Evidence summary
The current evidence is primarily based on in vitro, ex vivo, and in vivo animal models (Level D), demonstrating significant antioxidant, anti-inflammatory, and antimicrobial potential, but lacks human clinical trials.
PubMed sources
1.PMID: 40442159 (2025) — Selenium content and bioaccumulation in Bidens tripartita and Bidens frondosa under different habitat conditions in Poland and Montenegro. · Scientific reports
2.PMID: 32442590 (2020) — Evaluation of the effects of Bidens tripartita extracts and their main constituents on intestinal motility - An ex vivo study. · Journal of ethnopharmacology
3.PMID: 27872708 (2016) — Anti-hyperglycaemic and antioxidant effects of Bidens tripartita and quantitative analysis on its active principles. · Iranian journal of basic medical sciences
4.PMID: 24502053 (2013) — In vivo biocompatibility evaluation of some Bidens tripartita extracts in rats. · Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
— Experimental researches on acute toxicity of a Bidens tripartita extract in mice - preliminary investigations.
· Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi
6.PMID: 18540165 (2007) — Antioxidant activity of extracts and flavonoids from Bidens tripartita. · Acta poloniae pharmaceutica
7.PMID: 24742754 (2014) — Medicinal plants of the Russian Pharmacopoeia; their history and applications. · Journal of ethnopharmacology
8.PMID: 33935397 (2021) — The vulnerary potential of botanical medicines in the treatment of bacterial pathologies in fish. · Veterinary world
9.PMID: 30275354 (2018) — Novel Gel Formulations as Topical Carriers for the Essential Oil of Bidens tripartita for the Treatment of Candidiasis. · Molecules (Basel, Switzerland)
10.PMID: 27231727 (2016) — A micelle mediated extraction as a new method of obtaining the infusion of Bidens tripartita. · Acta biochimica Polonica
11.PMID: 25830954 (2015) — Investigation of recovery of volatiles of Bidens tripartita L. using solid-phase extraction trap in supercritical fluid extraction. · Acta chimica Slovenica
12.PMID: 42312292 (2026) — Bioactive plant metabolites with antihyperglycemic properties: prospects for the prevention and treatment of diabetes mellitus. · 3 Biotech
13.PMID: 29217268 (2018) — Novel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L. · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
14.PMID: 19056546 (2008) — Antimicrobial and antifungal activities of the extracts and essential oils of Bidens tripartita. · Folia histochemica et cytobiologica
15.PMID: 24914718 (2014) — Antibacterial and quorum sensing regulatory activities of some traditional Eastern-European medicinal plants. · Acta pharmaceutica (Zagreb, Croatia)
16.PMID: 37446627 (2023) — Antiangiogenic, Anti-Inflammatory and Antioxidant Properties of Bidens tripartite Herb, Galium verum Herb and Rumex hydrolapathum Root. · Molecules (Basel, Switzerland)
17.PMID: 41463411 (2025) — Anthelmintic Activity of Traditional Medicinal Plants Used in Europe. · Biology
18.PMID: 31810125 (2020) — In vivo anti-inflammatory and anti-allergic activities of cynaroside evaluated by using hydrogel formulations. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
19.PMID: 35615141 (2022) — Indigenous Microorganisms Offset Arbuscular Mycorrhizal Fungi-Induced Plant Growth and Nutrient Acquisition Through Negatively Modulating the Genes of Phosphorus Transport and Nitrogen Assimilation. · Frontiers in plant science
20.PMID: 31627100 (2019) — Incorporation of bioflavonoids from Bidens tripartite into micelles of non-ionic surfactants - experimental and theoretical studies. · Colloids and surfaces. B, Biointerfaces
21.PMID: 35468152 (2022) — Indigenous microorganisms offset the benefits of growth and nutrition regulated by inoculated arbuscular mycorrhizal fungi for four pioneer herbs in karst soil. · PloS one
22.PMID: 19748256 (2010) — Anti-inflammatory activity of a HPLC-fingerprinted aqueous infusion of aerial part of Bidens tripartita L. · Phytomedicine : international journal of phytotherapy and phytopharmacology
23.PMID: 26385445 (2016) — Synthesis and evaluation of substituted 3-(pyridin-2-yl)benzenesulfonamide derivatives as potent herbicidal agents. · Bioorganic & medicinal chemistry
24.PMID: 25310699 (2014) — The relation between polyaromatic hydrocarbon concentration in sewage sludge and its uptake by plants: Phragmites communis, Polygonum persicaria and Bidens tripartita. · PloS one
25.PMID: 38286306 (2024) — Effect of ammonium sulfate combined with aqueous bio-chelator on Cd uptake by Cd-hyperaccumulator Solanum nigrum L. · Chemosphere
26.PMID: 26206119 (2015) — Performance and responses to competition in two congeneric annual species: does seed heteromorphism matter? · Plant biology (Stuttgart, Germany)
27.PMID: 30993042 (2019) — Vegetation dynamics of abandoned paddy fields and surrounding wetlands in the lower Tumen River Basin, Northeast China. · PeerJ
28.PMID: 21370967 (2011) — Composition of the essential oil of Bidens tripartita L. roots and its antibacterial and antifungal activities. · Journal of medicinal food
29.PMID: 11639707 (1992) — [Historical and herbalogical studies on coloring crude drug (Part 1): "Langbacao"]. · Yakushigaku zasshi