PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Daily supplementation with 0.25 mg/day of S-allyl-cysteine (SAC) for 12 weeks resulted in a reduction of systolic blood pressure by 1.8 mmHg and diastolic blood pressure by 1.5 mmHg, alongside increased blood nitric oxide and antioxidant capacity [PMID:37686723].
A meta-analysis of 9 RCTs found that aged garlic extract (AGE) tea supplementation reduces systolic blood pressure (WMD: -4.03) and diastolic blood pressure (WMD: -1.44), with higher doses showing more significant decreases [PMID:39437887].
In diet-induced obese C57BL/6 mice, aged black garlic alleviated obesity and muscle atrophy while enhancing myogenic differentiation and myotube hypertrophy [PMID:37163777].
Aged garlic exhibits anticancer effects and potential for cancer prevention and improvement of malignancy-related factors [PMID:30487964, PMID:30704623].
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 34443625 (2021) — Black Garlic and Its Bioactive Compounds on Human Health Diseases: A Review. · Molecules (Basel, Switzerland)
- 2.PMID: 37686723 (2023) — Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial. · Nutrients
- 3.PMID: 38339077 (2024) — Anti-Cancer and Anti-Inflammatory Properties of Black Garlic. · International journal of molecular sciences
- 4.PMID: 36125851 (2022) — Black garlic: A review of its biological significance. · Journal of food biochemistry
- 5.PMID: 30487964 (2018) — Aged Garlic and Cancer: A Systematic Review.