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Allium sativum
This herb may interact with medications you are taking. Review the interactions table below and consult your healthcare provider before use.
Garlic is one of the oldest cultivated plants, used for both culinary and medicinal purposes for over 5,000 years. It has been extensively studied for its cardiovascular benefits, antimicrobial properties, and immune-boosting effects. Louis Pasteur first documented its antibacterial properties in 1858.
Garlic (Allium sativum) is one of the most researched botanicals for cardiovascular health. Aged garlic extract demonstrates consistent effects on cholesterol and blood pressure.
Allicin inhibits HMG-CoA reductase, reduces cholesterol synthesis, and enhances bile acid excretion. Activates nitric oxide synthase, improving endothelial function. Antiplatelet effects inhibit thromboxane A2.
Hyperlipidemia
15-25 mg/dL total cholesterol reduction
Hypertension
8-10 mmHg systolic reduction
Platelet aggregation inhibition
Well-documented antiplatelet effects
Antimicrobial
Documented antibacterial, antifungal activity
| Drug | Severity | Description |
|---|---|---|
| Isoniazid | Moderate | Garlic may reduce isoniazid absorption and blood levels, potentially reducing its effectiveness for tuberculosis treatment. |
| Aspirin | Moderate | Garlic may increase the antiplatelet effects of aspirin, elevating bleeding risk. |
| Cyclosporine | Moderate | Garlic supplements may reduce cyclosporine levels, potentially increasing transplant rejection risk. |
| Saquinavir | Severe | Garlic supplements reduce saquinavir blood levels by approximately 51%, potentially compromising HIV treatment. |
| Warfarin (Coumadin) | Severe | Garlic supplements may increase anticoagulant effect of warfarin and increase bleeding risk. Cases of increased INR and bleeding have been reported. |
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