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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before using herbs, especially if you are pregnant, nursing, taking medications, or have a medical condition.
How does Campomanesia xanthocarpa work for weight loss?
Campomanesia xanthocarpa contains flavonoids, tannins, and phenolic compounds that may support metabolic function through antioxidant and anti-inflammatory properties. Laboratory studies suggest these bioactive constituents may modulate glucose metabolism and reduce oxidative stress. The herb's traditional use for weight management in Brazilian folk medicine aligns with these proposed mechanisms, though human clinical trials confirming these effects are limited. Evidence Level: C (preliminary research).
Does Campomanesia xanthocarpa interact with diabetes medications?
Campomanesia xanthocarpa may interact with antidiabetic medications such as metformin or insulin due to its potential blood sugar-lowering effects. Concurrent use could cause additive hypoglycemic effects, leading to dangerously low blood glucose levels. Patients taking diabetes medications should monitor glucose closely and consult a healthcare provider before use. Evidence Level: C. Always inform your physician about herbal supplement use.
What is the recommended dosage for Campomanesia xanthocarpa?
The traditional adult dosage is 2-3 grams of dried leaf prepared as a tea, typically taken once or twice daily. To prepare, steep the dried leaves in hot water for 10-15 minutes before straining. Standardized extracts may have different dosing guidelines. Evidence Level: Traditional. Consult a qualified herbalist for personalized recommendations, as clinical trials establishing optimal therapeutic doses are currently lacking.
Is Campomanesia xanthocarpa safe during pregnancy?
Campomanesia xanthocarpa is considered unsafe during pregnancy and should be avoided. There is insufficient safety data regarding use in pregnant or breastfeeding women, and traditional contraindications specifically note pregnancy caution due to potential uterine effects. Women who are pregnant, planning pregnancy, or breastfeeding should not use this herb without explicit medical supervision. Evidence Level: C.
What is Campomanesia xanthocarpa used for?
Campomanesia xanthocarpa is traditionally used in Brazilian folk medicine for weight management, blood sugar support, and reducing inflammation. The herb contains flavonoids, tannins, terpenoids, and phenolic acids that contribute to its antioxidant and anti-inflammatory properties. Preliminary research supports these traditional applications for metabolic health. Evidence Level: C. More rigorous human clinical trials are needed to confirm efficacy for these uses.
PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Campomanesia xanthocarpa, known as guabiroba or gabiroba, is a Brazilian Myrtaceae species with demonstrated antioxidant, anti-inflammatory, and hypolipidemic properties [PMID: 33727941, 31658881, 32700557].
Background
Campomanesia xanthocarpa (also referred to as guabiroba or gabiroba) is a plant species native to the Brazilian Atlantic Forest and Cerrado regions [PMID: 38201151, 32531999]. It belongs to the Myrtaceae family [PMID: 32876168].
Traditional uses
It is traditionally used in Brazilian folk medicine to treat diabetes, fever, hypercholesterolemia, obesity, urinary tract diseases, diarrhea, inflammation, and ulcers [PMID: 33727941, 15261963, 30741125, 28584558].
Active compounds
The plant contains phenolic compounds, flavonoids, tannins, saponins, and steroids [PMID: 15261963, 32700557]. Specific identified compounds include $\beta$-caryophyllene (major compound in seed SCCO2 extract) [PMID: 33727941], chlorogenic acid, gallic acid, quercetin, theobromine [PMID: 28584558], and catechin and ferulic acid in fruits [PMID: 37971652]. Leaf essential oil contains sesquiterpene hydrocarbons such as trans-caryophyllene, bicyclogermacrene, and $\delta$-cadinene [PMID: 32998582].
Mechanism of action
The plant exhibits anti-inflammatory effects by inhibiting neutrophil migration induced by LPS in vitro [PMID: 33727941]. Antidiabetic potential is linked to the inhibition of $\alpha$-amylase and $\beta$-glucosidase activities [PMID: 40724290, 37971652] and the inhibition of sucrase and maltase activity [PMID: 32876168]. Antidepressant-like effects are associated with the monoaminergic system [PMID: 35747347].
Clinical evidence
Evidence BHypercholesterolemia
Encapsulated C. xanthocarpa was studied for its effect on biochemical and oxidative stress parameters in patients [PMID: 19914369].
Evidence BPlatelet Aggregation
Treatment with C. xanthocarpa (1000mg) caused a reduction of 8±13.5% in ADP-induced platelet aggregation in healthy subjects after 5 days [PMID: 28410506].
Evidence DInflammation/Pain (Animal)
Seed extract (60 mg/kg) reduced nociceptive behavior in the formalin test and prevented carrageenan-induced paw edema in mice [PMID: 33727941].
Evidence DGastric Ulcers (Animal)
Hydroalcoholic leaf extract (400 mg/kg) was effective in preventing gastric ulceration in rats [PMID: 15261963].
Evidence DHyperglycemia (Animal)
Seed extract (400 mg/kg) decreased blood glucose levels and increased muscular and hepatic glycogen content in rats [PMID: 32876168].
Evidence DDepression (Animal)
Safety & adverse effects
Seed extracts showed no hepatic or renal toxic effects in rats [PMID: 32876168]. Leaf extracts did not produce toxic symptoms in mice at doses up to 5 g/kg [PMID: 15261963]. However, an aqueous leaf extract induced mutations in TA98, TA97a, and TA102 strains in vitro [PMID: 30741125]. Fruit flour extracts showed no evidence of proliferative activity or toxicity in Artemia salina or Lactuca sativa [PMID: 38201151].
Drug interactions
C. xanthocarpa was studied in combination with acetylsalicylic acid (ASA), showing a reduction of 12.5±5% in ADP-induced platelet aggregation when used synergistically (500mg C. xanthocarpa + 50mg ASA) [PMID: 28410506].
Evidence summary
The evidence consists primarily of in vitro studies and animal models (Level D), with a few small-scale human clinical trials (Level B) regarding lipid and platelet parameters. Most findings are preliminary.
PubMed sources
1.PMID: 33642002 (2021) — Influence of guabiroba pulp (campomanesia xanthocarpa o. berg) added to fermented milk on probiotic survival under in vitro simulated gastrointestinal conditions. · Food research international (Ottawa, Ont.)
2.PMID: 37971088 (2023) — Campomanesia xanthocarpa (Myrtaceae: Myrtoideae) seedlings reveal morpho-physiological plasticity under shade conditions. · Brazilian journal of biology = Revista brasleira de biologia
3.PMID: 33727941 (2021) — Anti-Inflammatory Effects of Campomanesia xanthocarpa Seed Extract Obtained from Supercritical CO2. · Evidence-based complementary and alternative medicine : eCAM
4.PMID: 31200215 (2019) — Evaluation of the in vitro photoprotective potential of ethanolic extracts of four species of the genus Campomanesia. · Journal of photochemistry and photobiology. B, Biology
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Seed extract significantly reduced immobility time in the tail suspension test (TST) in mice [PMID: 35747347].
Evidence DMelanoma (In Vitro)
Leaf and fruit infusions demonstrated antineoplastic effects by reducing cell viability in SK-MEL-28 cells [PMID: 39569036].
— Antidepressant-like effect of Campomanesia xanthocarpa seeds in mice: Involvement of the monoaminergic system.
· Journal of traditional and complementary medicine
6.PMID: 15261963 (2004) — Antiulcerogenic effects of Campomanesia xanthocarpa. · Journal of ethnopharmacology
7.PMID: 19914369 (2010) — Effects of Campomanesia xanthocarpa on biochemical, hematological and oxidative stress parameters in hypercholesterolemic patients. · Journal of ethnopharmacology
8.PMID: 32779212 (2020) — Polyphenolic compounds with biological activity in guabiroba fruits (Campomanesia xanthocarpa Berg.) by comprehensive two-dimensional liquid chromatography. · Electrophoresis
9.PMID: 32806393 (2020) — Sensitivity of different parameters for selection of higher plants in urban afforestation: Exposure of Guabiroba (Campomanesia xanthocarpa O. Berg.) to diesel engine exhaust. · Environmental pollution (Barking, Essex : 1987)
10.PMID: 32607091 (2020) — Antidiabetic Potential of Syzygium sp.: An Overview. · The Yale journal of biology and medicine
11.PMID: 32876168 (2021) — Antidiabetic and hypolipidemic potential of Campomanesia xanthocarpa seed extract obtained by supercritical CO2. · Brazilian journal of biology = Revista brasleira de biologia
12.PMID: 38201151 (2023) — Cytotoxic and Phytotoxic Activities of Native Brazilian Forest Gabiroba (Campomanesia xanthocarpa Berg.), Fruits, and Flour against Shrimp (Artemia salina L.) and Lettuce (Lactuca sativa L.). · Foods (Basel, Switzerland)
13.PMID: 28410506 (2017) — Inhibitory effect of Campomanesia xanthocarpa in platelet aggregation: Comparison and synergism with acetylsalicylic acid. · Thrombosis research
14.PMID: 31593892 (2020) — A critical review of some fruit trees from the Myrtaceae family as promising sources for food applications with functional claims. · Food chemistry
15.PMID: 30741125 (2019) — Toxicological aspects of Campomanesia xanthocarpa Berg. associated with its phytochemical profile. · Journal of toxicology and environmental health. Part A
16.PMID: 28584558 (2017) — Chemical Composition and Hypotensive Effect of Campomanesia xanthocarpa. · Evidence-based complementary and alternative medicine : eCAM
17.PMID: 31658881 (2019) — Anti-hyperlipidemic effects of Campomanesia xanthocarpa aqueous extract and its modulation on oxidative stress and genomic instability in Wistar rats. · Journal of toxicology and environmental health. Part A
18.PMID: 37109395 (2023) — The Use of Medicinal Plants in Blood Vessel Diseases: The Influence of Gender. · Life (Basel, Switzerland)
19.PMID: 32998582 (2021) — Campomanesia xanthocarpa (Mart.) O. Berg essential oil induces antileishmanial activity and remodeling of the cytoplasm organelles. · Natural product research
20.PMID: 35358579 (2022) — Isolation, NMR characterization and bioactivity of a (4-O-methyl-α-D-glucurono)-β-D-xylan from Campomanesia xanthocarpa Berg fruits. · International journal of biological macromolecules
21.PMID: 31696028 (2019) — Repetitive genomic elements in Campomanesia xanthocarpa: prospection, characterization and cross amplification of molecular markers. · 3 Biotech
22.PMID: 36297820 (2022) — An Integrative Review on the Main Flavonoids Found in Some Species of the Myrtaceae Family: Phytochemical Characterization, Health Benefits and Development of Products. · Plants (Basel, Switzerland)
23.PMID: 32700557 (2021) — Dereplication and evaluation of the antinociceptive and anti-inflammatory activity of hydroethanolic extract of leaves from Campomanesia xanthocarpa O. Berg. · Natural product research
25.PMID: 39569036 (2024) — Phytotherapeutic potential of Campomanesia xanthocarpa (Mart.) O. Berg: antitumor effects in vitro and in silico, with emphasis on SK-MEL-28 melanoma cells-a study on leaf and fruit infusions. · In silico pharmacology
26.PMID: 38056731 (2024) — Development and characterization of films from Campomanesia xanthocarpa and commercial citrus pectins with different degrees of methyl-esterification. · International journal of biological macromolecules
27.PMID: 32531999 (2020) — Effect of Supplementation with Hydroethanolic Extract of Campomanesia xanthocarpa (Berg.) Leaves and Two Isolated Substances from the Extract on Metabolic Parameters of Mice Fed a High-Fat Diet. · Molecules (Basel, Switzerland)
28.PMID: 40870769 (2025) — The Brazilian Native Fruits Araçá, Guabijú, and Guabiroba: A Brief and Integrative Review on Their Phenolic Composition and Analytical Methods. · Foods (Basel, Switzerland)
29.PMID: 26776955 (2016) — Study of oxidative and inflammatory parameters in LDLr-KO mice treated with a hypercholesterolemic diet: Comparison between the use of Campomanesia xanthocarpa and acetylsalicylic acid. · Phytomedicine : international journal of phytotherapy and phytopharmacology
30.PMID: 37971652 (2024) — Nutritional Composition, Simulated Digestion and Biological Activities of Campomanesia xanthocarpa Fruit. · Plant foods for human nutrition (Dordrecht, Netherlands)