PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 26 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Paratrimerin I showed submicromolar cytotoxicity (IC50 0.26 µM) [PMID:32496136]; methanol root extract demonstrated toxicity in 3D multicellular tumor spheres [PMID:29687285].
Root extract (100-200 µg/ml) showed significantly higher cytotoxic potential than its fractions [PMID:28029227] and impressive cytotoxic capacity against BxPc3 and CFPAC1 cell lines [PMID:30880785].
Paratrimerin I showed submicromolar cytotoxicity against HepG2 (IC50 0.43 µM) [PMID:32496136], while paratrimerin Z did not show cytotoxicity against Hep3B [PMID:36008765].
Isolated compounds from stems inhibited nitrite and PGE2 concentrations and suppressed iNOS and COX-2 protein expression in LPS-stimulated BV2 cells [PMID:28245363].
Leaf essential oils inhibited Staphylococcus aureus (MIC 2% v/v) [PMID:32344551], and peel extracts showed antibacterial activity against P. aeruginosa, Salmonella sp., and S. aureus [PMID:34513112].
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 28245363 (2017) — Anti-inflammatory coumarins from Paramignya trimera. · Pharmaceutical biology
- 2.PMID: 29687285 (2020) — Anti-cancer Effect of Xao Tam Phan Paramignya trimera Methanol Root Extract on Human Breast Cancer Cell Line MCF-7 in 3D Model. · Advances in experimental medicine and biology
- 3.PMID: 33303786 (2020) — Phylogenetic relationship of Paramignya trimera and its relatives: an evidence for the wide sexual compatibility. · Scientific reports
- 4.PMID: 28029227 (2017) — Physicochemical, Antioxidant, and Cytotoxic Properties of Xao Tam Phan (Paramignya trimera) Root Extract and Its Fractions. · Chemistry & biodiversity
- 5.PMID: 28122160 (2017)