This product is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before using herbs, especially if you are pregnant, nursing, taking medications, or have a medical condition.
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Coreopsis tinctoria is a traditional medicinal plant used in North America, Europe, and Asia, recognized for its antioxidant, antihyperglycemic, and anti-inflammatory properties [PMID:33309917, PMID:38919005].
Background
Coreopsis tinctoria Nutt. (family Asteraceae), also known as 'Snow Chrysanthemum' or 'Shemuju', is a medicinal plant found in plateau areas exceeding 3000m, particularly in regions like Xinjiang, China [PMID:33309917, PMID:38084786, PMID:24228578].
Traditional uses
It has been used traditionally for disinfection, treatment of sexual infections, diarrhea, acute and chronic dysentery, red-eye swelling, pain, heat, thirst, hypertension, palpitation, gastrointestinal discomfort, and loss of appetite [PMID:33309917]. In Portugal, flowering tops infusion is used for diabetes symptoms [PMID:22143153], and in Xinjiang, it is consumed as a herbal tea for high blood pressure and diarrhea [PMID:30630477].
Active compounds
The plant is rich in flavonoids, including marein, flavanomarein, okanin, kaempferol, quercetin, and isorhamnetin [PMID:35334817, PMID:36570002, PMID:35962784, PMID:40437103]. Other identified compounds include polyacetylenes [PMID:25563069], biflavonones (sikokianin D and E) [PMID:28374625], and various chalcones and flavanones [PMID:30499349, PMID:36630026].
Mechanism of action
Mechanisms include the modulation of SIRT1/Nrf2 signaling to alleviate oxidative stress and lipid accumulation [PMID:40437103], inhibition of IKKβ-mediated NF-κB p65 phosphorylation to protect against bone loss [PMID:41109043], and regulation of TGF-β1/SMADS/AMPK/NF-κB pathways to reduce renal fibrosis [PMID:30630477]. It also acts via SIRT3 pathways to protect against UVA-induced mitochondrial dysfunction [PMID:41008947] and modulates Nrf2/HO-1 and MAPK pathways for neuroprotection [PMID:41906277].
Clinical evidence
Evidence DHyperglycemia/Diabetes
C. tinctoria and its flavonoids lowered body weight, reduced fasting blood glucose, and improved glucose tolerance and insulin resistance in obese mice [PMID:35334817]; reversed levels of glucose, insulin, and HbA1c in db/db mice [PMID:36736673].
Evidence DHyperlipidemia
Flavonoids from C. tinctoria adjusted lipid metabolism by down-regulating adipose differentiation-related protein (ADRP) in hyperlipemia mice [PMID:25512113].
Evidence DSkin Photoaging
Okanin reduced malondialdehyde content and relieved epidermal hyperplasia and dermal damage caused by UVB irradiation in mice [PMID:39024749].
Evidence DOsteoporosis
Okanin attenuated ovariectomy-induced bone loss in a murine model [PMID:41109043].
Evidence DChronic Myelogenous Leukemia (CML)
Flower extracts were investigated for their ability to impair CML cell survival (K562 cells) [PMID:38919005].
Evidence D
Evidence summary
The evidence consists primarily of in vitro cell studies and in vivo animal models (mice/rats), indicating strong potential for metabolic and antioxidant activity, but lacks human clinical trials.
PubMed sources
1.PMID: 33309917 (2021) — Traditional uses, phytochemistry, pharmacology, and toxicology of Coreopsis tinctoria Nutt.: A review. · Journal of ethnopharmacology
2.PMID: 28374625 (2017) — Two new biflavonones from Coreopsis tinctoria. · Journal of Asian natural products research
4.PMID: 25563069 (2015) — Novel polyacetylenes from Coreopsis tinctoria Nutt. · Journal of Asian natural products research
5.PMID: 35334817 (2022) — Coreopsis tinctoria and Its Flavonoids Ameliorate Hyperglycemia in Obese Mice Induced by High-Fat Diet.
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
Polyphenols ameliorated acrylamide-induced gait abnormalities and reduced brain injury markers MBP and GFAP in mice [PMID:41906277].
· Nutrients
6.PMID: 36570002 (2022) — Metabolomics study of flavonoids in Coreopsis tinctoria of different origins by UPLC-MS/MS. · PeerJ
7.PMID: 34691233 (2021) — Protective Effect of Effective Components of Coreopsis tinctoria Nutt on Retinopathy of db/db Diabetic Mice. · Evidence-based complementary and alternative medicine : eCAM
8.PMID: 38496841 (2024) — Coreopsis tinctoria improves energy metabolism in obese hyperglycemic mice. · Heliyon
9.PMID: 40437103 (2025) — Marein from Coreopsis tinctoria Nutt. alleviates oxidative stress and lipid accumulation via SIRT1/Nrf2 signaling. · Scientific reports
10.PMID: 35962784 (2022) — Study on the metabolism profile of flavanomarein in Coreopsis tinctoria Nutt. · Journal of separation science
11.PMID: 32464313 (2020) — Okanin in Coreopsis tinctoria Nutt is a major quorum-sensing inhibitor against Chromobacterium violaceum. · Journal of ethnopharmacology
12.PMID: 25512113 (2014) — Flavonoids furom Coreopsis tinctoria adjust lipid metabolism in hyperlipidemia animals by down-regulating adipose differentiation-related protein. · Lipids in health and disease
13.PMID: 41395282 (2025) — Integrated network pharmacology and experimental validation reveal Coreopsis tinctoria Total Flavonoids (CTFs) as potential therapeutic agents against hepatocellular carcinoma. · American journal of cancer research
14.PMID: 41109043 (2025) — Okanin attenuates ovariectomy-induced bone loss in mice model through inhibition of IKKβ-mediated NF-κB p65 phosphorylation. · Phytomedicine : international journal of phytotherapy and phytopharmacology
15.PMID: 35993096 (2022) — Supercritical CO2 extraction, chemical composition, and antioxidant effects of Coreopsis tinctoria Nutt. oleoresin. · Open life sciences
16.PMID: 30630477 (2019) — Coreopsis tinctoria Nutt ameliorates high glucose-induced renal fibrosis and inflammation via the TGF-β1/SMADS/AMPK/NF-κB pathways. · BMC complementary and alternative medicine
17.PMID: 38084786 (2024) — UPLC-quadrupole time-of-flight-tandem mass spectrometry combined with chemometrics and network pharmacology to differentiate Coreopsis tinctoria Nutt. · Biomedical chromatography : BMC
18.PMID: 32372278 (2020) — Detection of 16SrVI and 16SrIX phytoplasma groups in pot marigold and tickseed plants in northeastern Iran. · Folia microbiologica
19.PMID: 35356116 (2022) — Comparison of Metabolome and Transcriptome of Flavonoid Biosynthesis in Two Colors of Coreopsis tinctoria Nutt. · Frontiers in plant science
20.PMID: 36736673 (2023) — Protective effects of flavonoids in Coreopsis tinctoria Nutt. in a mouse model of type 2 diabetes. · Journal of ethnopharmacology
21.PMID: 39024749 (2024) — Anti-photoaging effect and the mechanism of Coreopsis tinctoria okanin against UVB-induced skin damage in mice. · International immunopharmacology
22.PMID: 41008947 (2025) — Okanin Attenuates Mitochondrial Dysfunction and Apoptosis in UVA-Induced HaCaT Cells by Mitophagy Through SIRT3 Pathway. · Antioxidants (Basel, Switzerland)
23.PMID: 22143153 (2012) — Cytoprotective effect of Coreopsis tinctoria extracts and flavonoids on tBHP and cytokine-induced cell injury in pancreatic MIN6 cells. · Journal of ethnopharmacology
24.PMID: 30499349 (2020) — The chemical components of Coreopsis tinctoria Nutt. and their antioxidant, antidiabetic and antibacterial activities. · Natural product research
25.PMID: 39509897 (2025) — Gradient ethanol extracts of Coreopsis tinctoria buds: Chemical and in vitro fermentation characteristics. · Food chemistry
26.PMID: 41906277 (2026) — Coreopsis tinctoria Nutt. polyphenols attenuate acrylamide-induced cerebral injury via dual modulation of Nrf2/HO-1 and MAPK pathways. · Journal of the science of food and agriculture
27.PMID: 34434650 (2021) — Physiological changes and transcript identification in Coreopsis tinctoria Nutt. in early stages of salt stress. · PeerJ
28.PMID: 40526161 (2025) — Coreopsis Tinctoria flavonoids phospholipid complex: molecular dynamics simulation, preparation, characterization, and in vitro release. · Drug development and industrial pharmacy
29.PMID: 36630026 (2023) — Aromatase inhibitors isolated from a flowering tea, snow Chrysanthemum (the capitula of Coreopsis tinctoria Nutt.). · Journal of natural medicines
30.PMID: 24228578 (2013) — [Research advance in medicinal plants from genus Coreopsis]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica