PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Rhizome-derived exosomes reduced ROS levels and improved mitochondrial function, enhancing cell migration and 3D spheroid formation [PMID:40362310]
Aqueous extract was examined for therapeutic effects on Amyloid β-induced memory impairment in Wistar rats using the Morris water maze test [PMID:28638877]
Hydroalcoholic extract of rhizomes (100 and 200 mg/kg/day) significantly reduced serum levels of glucose, triglycerides, BUN, AST, ALT, and ALP in streptozotocin-induced diabetic rats [PMID:33953776]
Nine isolated isoflavonoids demonstrated anti-inflammatory activity in a spectrophotometric assay using activated human neutrophils [PMID:12738083]
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 40603676 (2025) — Synthesis and olfactory evaluation of (±)-β-irone. · Scientific reports
- 2.PMID: 40362310 (2025) — Iris germanica L. Rhizome-Derived Exosomes Ameliorated Dihydrotestosterone-Damaged Human Follicle Dermal Papilla Cells Through the Activation of Wnt/β-Catenin Pathway. · International journal of molecular sciences
- 3.PMID: 35312472 (2022) — Pseudomonas germanica sp. nov., isolated from Iris germanica rhizomes. · International journal of systematic and evolutionary microbiology
- 4.PMID: 37487858 (2023) — FEMA GRAS assessment of natural flavor complexes: Sage oil, Orris Root Extract and Tagetes Oil and related flavoring ingredients. · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- 5.PMID: 25441349