PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Leaf extract and myricitrin ameliorated histamine-independent pruritus and inhibited itch-related IL-6 and IL-31 by suppressing microglial inflammation and astrocyte activation [PMID:37346401, PMID:39129303]
A mixture of D. lotus leaf extract and red okra (or grape stalk extract) reduced lipid accumulation, prevented weight gain, and improved plasma lipid profiles in HFD-induced obese mice [PMID:41016817, PMID:31275721]
Topical application of leaf extract reversed UVB-induced skin damage in mice by inhibiting oxidative stress and collagen degradation [PMID:28850926]
Fruit extract showed a protective role against cisplatin-induced heart damage and oxidative stress in rats [PMID:35509232]
Leaf extract enhanced differentiation of MC3T3-E1 pre-osteoblasts and increased osteogenic molecules in ovariectomized mice [PMID:38674937]
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 36112569 (2022) — Drying date plum (Diospyros lotus L.) fruit: Assessing rehydration properties, antioxidant activity, and phenolic compounds. · Journal of food science
- 2.PMID: 24803703 (2014) — Antioxidant activities and phenolic compounds of date plum persimmon ( Diospyros lotus L.) fruits. · Journal of food science and technology
- 3.PMID: 39479648 (2024) — Anticancer therapeutic potential of genus Diospyros: From phytochemistry to clinical applications-A review. · Food science & nutrition
- 4.PMID: 37346401 (2023) — Diospyros lotus leaf extract and its main component myricitrin regulate pruritus through the inhibition of astrocyte activation. · Experimental and therapeutic medicine
- 5.PMID: 41016817