PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Systematic review and meta-analysis indicate efficacy in improving bone mineral density (BMD), trabecular microarchitecture, and biomechanical properties [PMID:41850642]
Water extract of D. roosii reversed body weight gain, gonadal fat mass, and trabecular bone loss in ovariectomized mice fed a high-fat diet [PMID:31443447]
Drynaria roosii-derived exosome-like nanovesicles and naringenin chalcone promoted mineralization and bone regeneration [PMID:42163262]
As part of the Gubi Zhitong formula, D. roosii contributed to alleviating KOA by regulating the Piezo1 mediated Ca2+ signaling pathway and PI3K/Akt/NF-κB axis [PMID:41173085]
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 33473696 (2017) — Complete chloroplast genome sequence of the medical fern Drynaria roosii and its phylogenetic analysis. · Mitochondrial DNA. Part B, Resources
- 2.PMID: 35240135 (2022) — Liglaurates A-E, cytotoxic bis(lauric acid-12yl)lignanoates from the rhizomes of Drynaria roosii Nakaike. · Phytochemistry
- 3.PMID: 41850642 (2026) — Efficacy of Rhizoma Drynariae (Drynaria roosii Nakaike) extracts in treating osteoporosis in rat models: A systematic review and meta-analysis. · Journal of ethnopharmacology
- 4.PMID: 39195505 (2024) — Epiphytic Patterns Impacting Metabolite Diversity of Drynaria roosii Rhizomes Based on Widely Targeted Metabolomics. · Metabolites
- 5.PMID: 15633809 (2004)