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Ssanghwa Tang Herbs
Eucommia ulmoides
Back and knee pain from kidney deficiency in TCM and Hanbang
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Eucommia ulmoides is a traditional medicinal herb used in China, Japan, and Korea with diverse pharmaceutical properties, including effects on bone health and metabolic disorders [PMID:35744822, PMID:29745662].
Background
Eucommia ulmoides Oliver (also known as Du Zhong) is a tree species native to China [PMID:39221141, PMID:30857406]. The medicinal parts of the plant include the bark (Eucommiae cortex) and leaves (Eucommiae folium) [PMID:39221141].
Traditional uses
Traditionally used in Chinese medicine to treat lumbar pain, knee pain, osteoporosis, hepatoprotection, paralysis, intestinal haemorrhoids, vaginal bleeding, abortion, spermatorrhoea, and foot fungus [PMID:34362420]. It is also used for tonifying the liver and kidney, strengthening muscles and bones, and miscarriage prevention [PMID:38972653, PMID:29745662].
Active compounds
Bioactive constituents include lignans (such as pinoresinol diglucoside), iridoids (such as aucubin and geniposide), phenolics, steroids, terpenoids, flavonoids, and polysaccharides [PMID:29745662, PMID:38442791, PMID:40630123, PMID:39221141]. It also contains trans-1,4-polyisoprene (Eucommia ulmoides rubber) [PMID:33761246].
Mechanism of action
Mechanisms include enhancing intestinal mucosal barrier function and antioxidant capacity [PMID:37438752], regulating the YAP/β-catenin/VEGF axis in bone marrow mesenchymal stem cells to promote fracture healing [PMID:39366157], and modulating the F. prausnitzii/butyrate/GPR43/GLP-1 signaling pathway to alleviate liver disease [PMID:40935212]. It may also remodel intestinal microbiota to reduce cerebral infarction and neuronal death [PMID:41288788].
Clinical evidence
Evidence AOsteoporosis
Extracts significantly improved bone mineral density in osteoporotic rat models [PMID:41059187].
Evidence DOsteoporosis (Lead-induced)
Cortex extract (100 mg/kg) alleviated lead acetate-induced bone loss in rats [PMID:29740803].
Evidence DHyperglycemia
Powdered leaves and water extracts significantly lowered blood glucose levels in streptozotocin-induced diabetic rats [PMID:15620430].
Evidence DColitis
Modified nano-selenium polysaccharides (EUP-SeNP) alleviated DSS-induced colitis in mice by restoring weight and reducing disease activity index [PMID:37438752].
Evidence DCerebral Ischemic Stroke
Extract reduced cerebral infarction area, ameliorated neurological deficits, and reduced neuronal death in mice [PMID:41288788].
Evidence DMASLD
Bark extract (EBE) showed protective effects against high-fat diet-induced metabolic dysfunction-associated steatotic liver disease in mice [PMID:40935212].
Safety & adverse effects
Eucommia ulmoides extract (EUE) is non-genotoxic within tested dose ranges; however, long-term administration (13 weeks) led to dose-dependent increases in nephrotoxicity-related indices and pathological changes in renal tissues, which persisted at high dosages (56 g/kg) [PMID:33122045].
Evidence summary
The evidence is primarily based on animal models (rats, mice, zebrafish) and in vitro studies, with one systematic review/meta-analysis of rat models. Clinical studies in humans are reported to be scarce [PMID:35744822, PMID:41059187].
PubMed sources
1.PMID: 37438752 (2023) — Eucommia ulmoides polysaccharide modified nano-selenium effectively alleviated DSS-induced colitis through enhancing intestinal mucosal barrier function and antioxidant capacity. · Journal of nanobiotechnology
2.PMID: 33761246 (2021) — Natural Polymer Eucommia Ulmoides Rubber: A Novel Material. · Journal of agricultural and food chemistry
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
— Single-cell RNA transcriptomics reveals Du-Zhong-Wan promotes osteoporotic fracture healing via YAP/β-catenin/VEGF axis in BMSCs.
· Phytomedicine : international journal of phytotherapy and phytopharmacology
6.PMID: 33122045 (2020) — Safety evaluation of Eucommia ulmoides extract. · Regulatory toxicology and pharmacology : RTP
7.PMID: 29745662 (2018) — Eucommia ulmoides Oliver: A Potential Feedstock for Bioactive Products. · Journal of agricultural and food chemistry
8.PMID: 40935212 (2026) — Eucommia alleviates high fat diet-induced MASLD via the F. prausnitzii/butyrate/GPR43/GLP-1 signaling. · Journal of ethnopharmacology
9.PMID: 40630123 (2025) — Eucommia ulmoides Oliv. and its bioactive compounds: therapeutic potential in bone diseases. · Frontiers in pharmacology
10.PMID: 35753260 (2022) — Chemical profiling, quantitation, and bioactivities of Du-Zhong tea. · Food chemistry
11.PMID: 39221141 (2024) — Advances in Eucommia ulmoides polysaccharides: extraction, purification, structure, bioactivities and applications. · Frontiers in pharmacology
12.PMID: 38732399 (2024) — Genome-Wide Identification and Expression Analysis of Growth-Regulating Factors in Eucommia ulmoides Oliver (Du-Zhong). · Plants (Basel, Switzerland)
13.PMID: 27042191 (2016) — Health-Promoting Properties of Eucommia ulmoides: A Review. · Evidence-based complementary and alternative medicine : eCAM
14.PMID: 24296089 (2014) — Eucommia ulmoides Oliv.: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine. · Journal of ethnopharmacology
15.PMID: 41059187 (2025) — Therapeutic effects of Eucommia ulmoides extract on osteoporosis rat models: a systematic review and meta-analysis. · Frontiers in pharmacology
16.PMID: 36904423 (2023) — Intelligent Eucommia ulmoides Rubber/Ionomer Blends with Thermally Activated Shape Memory and Self-Healing Properties. · Polymers
17.PMID: 30857406 (2019) — Ethnobotany, Phytochemistry and Pharmacological Properties of Eucommia ulmoides: A Review. · The American journal of Chinese medicine
18.PMID: 29740803 (2019) — Du-Zhong (Eucommia ulmoides Oliv.) Cortex Extract Alleviates Lead Acetate-Induced Bone Loss in Rats. · Biological trace element research
19.PMID: 37071384 (2023) — Extraction of Eucommia ulmoides gum and microbial lipid from Eucommia ulmoides Oliver leaves by dilute acid hydrolysis. · Biotechnology letters
20.PMID: 34362420 (2021) — Traditional application and modern pharmacological research of Eucommia ulmoides Oliv. · Chinese medicine
21.PMID: 15620430 (2005) — Hypoglycemic effect of Du-zhong (Eucommia ulmoides Oliv.) leaves in streptozotocin-induced diabetic rats. · Diabetes research and clinical practice
22.PMID: 37110564 (2023) — Quantitative Detection of Natural Rubber Content in Eucommia ulmoides by Portable Pyrolysis-Membrane Inlet Mass Spectrometry. · Molecules (Basel, Switzerland)
23.PMID: 38972653 (2024) — Preparation techniques, structural features, and bioactivities of Eucommia ulmoides polysaccharides: A review. · International journal of biological macromolecules
24.PMID: 38754661 (2024) — Histochemical studies on the distribution and accumulation of trans-polyisoprene in the rubber-producing plant Eucommia ulmoides. · International journal of biological macromolecules
25.PMID: 38902931 (2024) — Research Progress of Eucommia ulmoides Oliv and Predictive Analysis of Quality Markers Based on Network Pharmacology. · Current pharmaceutical biotechnology
26.PMID: 32767065 (2020) — Structure and Function of Bacterial Microbiota in Eucommia ulmoides Bark. · Current microbiology
27.PMID: 31226307 (2019) — PCL/EUG scaffolds with tunable stiffness can regulate macrophage secretion behavior. · Progress in biophysics and molecular biology
28.PMID: 34913224 (2022) — Metabolism of Du Zhong Formula in rats using UPLC-Q-TOF/MS. · Journal of mass spectrometry : JMS
29.PMID: 27173246 (2016) — Isolation and characterization of microsatellite markers for Eucommia ulmoides (Eucommiaceae), an endangered tree, using next-generation sequencing. · Genetics and molecular research : GMR
30.PMID: 41288788 (2025) — Eucommia ulmoides Oliver (Duzhong) extract ameliorates cerebral ischemic stroke in mice by remodeling intestinal microbiota and metabolites. · Metabolic brain disease