PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Clove essential oil inhibits Gram-negative and Gram-positive bacteria (e.g., E. coli, S. aureus, P. aeruginosa) and yeast [PMID:24031950]; it also inhibits S. pneumoniae growth and biofilms [PMID:23594212] and MDR S. enteritidis [PMID:35907084].
Used as a local antiseptic and anesthetic in medicine [PMID:32454614]; systemic administration in rats produced significant antinociceptive effects in acute corneal pain [PMID:27651809]; reduced pain response in formalin tests in mice [PMID:22453493].
Clove essential oil (0.011%) inhibited proinflammatory biomarkers such as VCAM-1 and interferon gamma in human dermal fibroblasts [PMID:28407719].
Aqueous and ethanolic extracts significantly extended the latency to seizures in PTZ-induced mouse models [PMID:23257144]; essential oil exhibited anticonvulsant activity against MES-induced tonic seizures [PMID:10197752].
Intraperitoneal administration in animal models significantly decreased immobility duration in forced swim and tail suspension tests [PMID:23462195].
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 32454614 (2017) — Pharmacological and Toxicological Properties of Eugenol. · Turkish journal of pharmaceutical sciences
- 2.PMID: 24031950 (2012) — Microbicide activity of clove essential oil (Eugenia caryophyllata). · Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
- 3.PMID: 38685512 (2024) — Anti-inflammatory naphthoquinone-monoterpene adducts and neolignans from Eugenia caryophyllata. · Fitoterapia
- 4.PMID: 17380552 (2007) — The chemical composition and biological activity of clove essential oil, Eugenia caryophyllata (Syzigium aromaticum L. Myrtaceae): a short review. · Phytotherapy research : PTR
- 5.PMID: 37040058 (2023)