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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 29 PubMed articles · model: gemma4:31b
Summary
Sweet basil (Ocimum basilicum) is an aromatic medicinal plant of the Lamiaceae family used for its diverse pharmacological properties, including antioxidant, antimicrobial, and anti-inflammatory effects [PMID:35741897, PMID:38140476].
Background
Ocimum basilicum L., commonly known as sweet basil, is a widely consumed aromatic herb and medicinal plant used globally as a spice and in traditional medicine [PMID:29865879, PMID:35741897, PMID:37446986].
Traditional uses
Traditional medicine uses include treatment of gastrointestinal disorders, inflammation, immune system issues, pyrexia, cancer [PMID:35741897], cardiovascular diseases, and obesity [PMID:38328459]. It is also used to treat various types of fever [PMID:36771120] and respiratory disorders [PMID:35046828]. In Persian traditional medicine, it has been used both as a galactogogue and to decrease breastmilk oversupply [PMID:30000886].
Active compounds
The plant contains phytochemicals including linalool, 1,8-cineole (eucalyptol), estragole, eugenol, methylchavicol, and methylcinnamate [PMID:30000886, PMID:38140476]. Other bioactive constituents include alkaloids, phenolics, flavonoids, tannins, saponins, cardiac glycosides, steroids, and glycosides [PMID:38257301].
Mechanism of action
Basil may act as a radical scavenger to alleviate oxidative stress [PMID:38433659]. Computational studies suggest O. basilicum miRNAs may modulate human target genes associated with PI3K-AKT and MAPK signaling pathways [PMID:29775783]. It may also improve inflammatory mediators such as IL-10, IL-4, TNF-α, IFN-γ, and nitric oxide (NO) [PMID:37275758].
Clinical evidence
Evidence DBacterial Infections
Ethanol extracts of leaves inhibited Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli in vitro [PMID:36800828].
Evidence DDiabetes-induced Renal Affection
In albino rats, O. basilicum significantly decreased blood glucose levels and increased total anti-oxidant capacity (TAC) compared to untreated diabetic rats [PMID:32082085].
Evidence DNeurotoxicity (AlCl3-induced)
Leaf and seed extracts alleviated neuronal dysfunction and oxidative biomarkers in a Drosophila melanogaster model [PMID:38433659].
Evidence DDengue Virus (DENV)
The lipophilic fraction of the stem showed significant reduction in DENV titre in vitro [PMID:36771120].
Evidence DPancreatic Cancer
Extracellular vesicles purified from basil leaves demonstrated apoptosis-inducing abilities in pancreatic cancer cells [PMID:38939903].
Safety & adverse effects
Basil is generally recognized as safe (GRAS) as a food by the U.S. FDA [PMID:30000886]. However, concerns have been raised regarding alkenylbenzenes (such as estragole), which may be procarcinogens or promutagens [PMID:30000886, PMID:29865879].
Pregnancy & lactation
Basil appears safe during breastfeeding in food amounts, but medicinal doses are recommended against during lactation due to estragole content and lack of safety data [PMID:30000886].
Evidence summary
The current evidence is primarily based on in vitro studies, animal models (rats, Drosophila), and literature reviews. There are no scientifically valid clinical trials supporting its use as a galactogogue [PMID:30000886].
2.PMID: 38140476 (2023) — Sweet Basil (Ocimum basilicum L.)-A Review of Its Botany, Phytochemistry, Pharmacological Activities, and Biotechnological Development. · Plants (Basel, Switzerland)
3.PMID: 35741897 (2022) — Differential Nutrition-Health Properties of Ocimum basilicum Leaf and Stem Extracts. · Foods (Basel, Switzerland)
4.PMID: 38433659 (2024) — Sweet basil (Ocimum basilicum) leaf and seed extracts alleviate neuronal dysfunction in aluminum chloride-induced neurotoxicity in Drosophila melanogaster Meigen model. · Drug and chemical toxicology
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
— The potential effects of Ocimum basilicum on health: a review of pharmacological and toxicological studies.
· Expert opinion on drug metabolism & toxicology
6.PMID: 38257301 (2024) — Antimicrobial and Other Pharmacological Properties of Ocimum basilicum, Lamiaceae. · Molecules (Basel, Switzerland)
7.PMID: 38188439 (2023) — The complete chloroplast genome of Ocimum basilicum L. var. basilicum (Lamiaceae) and its phylogenetic analysis. · Mitochondrial DNA. Part B, Resources
9.PMID: 37275758 (2023) — Anti-inflammatory, immunomodulatory and anti-oxidant effects of Ocimum basilicum L. and its main constituents: A review. · Iranian journal of basic medical sciences
10.PMID: 38813679 (2025) — Bio-active compounds and major biomedical properties of basil (Ocimum basilicum, lamiaceae). · Natural product research
11.PMID: 36800828 (2022) — Assessment of The Antibacterial Susceptibility of Ocimum basilicum. · Cellular and molecular biology (Noisy-le-Grand, France)
12.PMID: 37446986 (2023) — Basil (Ocimum basilicum) Landraces Can Be Used in a Water-Limited Environment. · Plants (Basel, Switzerland)
13.PMID: 35046828 (2021) — The Effect of Ocimum basilicum L. and Its Main Ingredients on Respiratory Disorders: An Experimental, Preclinical, and Clinical Review. · Frontiers in pharmacology
14.PMID: 38328459 (2024) — Chloroplast genome of Ocimum basilicum var. purpurascens Bentham 1830 (Lamiaceae). · Mitochondrial DNA. Part B, Resources
15.PMID: 38939903 (2024) — Anti-cancer bioactivity of sweet basil leaf derived extracellular vesicles on pancreatic cancer cells. · Journal of extracellular biology
16.PMID: 32082085 (2019) — Renoprotective Effect of Ocimum Basilicum (Basil) Against Diabetes-induced Renal Affection in Albino Rats. · Materia socio-medica
17.PMID: 36771120 (2023) — Anti-Dengue Activity of Lipophilic Fraction of Ocimum basilicum L. Stem. · Molecules (Basel, Switzerland)
18.PMID: 34202798 (2021) — Basil Seeds as a Novel Food, Source of Nutrients and Functional Ingredients with Beneficial Properties: A Review. · Foods (Basel, Switzerland)