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Euphorbia Hirta Plant
Euphorbia hirta
Asthma and bronchitis in tropical traditional medicine
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 29 PubMed articles · model: gemma4:31b
Summary
Euphorbia hirta is a tropical weed used in traditional medicine across Asia and the Philippines for various ailments, including respiratory disorders and dengue [PMID: 29849664, 35187071, 39290882].
Background
Euphorbia hirta, also known as Tawa-Tawa, is a common roadside weed found in tropical Asia and India [PMID: 29849664, 40061658].
Traditional uses
Traditionally used to treat respiratory ailments, dysentery, jaundice, digestive problems, and diarrhea [PMID: 35455080, 39290882]. In the Philippines, it is used in folklore medicine for the treatment of dengue [PMID: 29849664]. In India, Indonesia, and Angola, it has been used as a galactagogue and to improve colostrum quality [PMID: 30000943].
Active compounds
Identified constituents include flavonoids (such as Quercetin-3-O-alpha-rhamnoside and kaempferol), saponins, sterols (beta-sitosterol), terpenes (alpha-amyrin, beta-amyrin, lupeol, taraxerone), alkaloids, polyphenols, tannins, and mucilage [PMID: 25598628, 27033089, 28479737, 40061658]. Other identified compounds include heneicosane, tetracosane, phytol, and squalene [PMID: 40061720, 40061658].
Mechanism of action
Anti-inflammatory effects are mediated through the modulation of Nrf2 and NF-kappaB signaling pathways [PMID: 39505796]. In human keratinocytes, it suppresses TNF-alpha/IFN-gamma-induced inflammatory responses by down-regulating JNK or STAT1/3 pathways [PMID: 35455080]. It also suppresses the release of TNF-alpha and IL-6 from activated rat peritoneal mast cells [PMID: 17643865].
Clinical evidence
Evidence CDengue
Used in folklore medicine; a systematic review identified one human trial, though limited studies have been conducted on antidengue activity [PMID: 29849664]
Evidence DHepatotoxicity (CCl4-induced)
Ethanolic extracts exhibited potential in vitro antioxidant activity and protective effects in Wistar rats [PMID: 36268597]
Evidence DSnake Venom Toxicity
Quercetin-3-O-alpha-rhamnoside inhibited protease, phospholipase-A(2), hemolytic activity, and hemorrhage inducing activity of Naja naja venom in vitro and in mice models [PMID: 27033089]
Evidence DGastroesophageal Reflux Disease (GERD)
Whole plant extract and flavonoids were investigated in surgically induced GERD models in rats [PMID: 28479737]
Evidence DAnaphylaxis
Ethanolic extract showed anti-anaphylactic activity against compound 48/80-induced systemic anaphylaxis in rats and mice [PMID: 17643865]
Evidence D
Safety & adverse effects
Acute toxicity studies indicate the toxic dose may be above 3000 mg/kg [PMID: 25598628]. In silico assessments suggest several phytoconstituents are nontoxic [PMID: 40061720]. However, it has been identified as a potential antigen in air-borne contact dermatitis [PMID: 28150592].
Pregnancy & lactation
Used as a galactagogue in some cultures, but no scientifically valid clinical trials support this use, and no data exist on the excretion of components into breastmilk [PMID: 30000943].
Evidence summary
The evidence is primarily based on in vitro studies, animal models (D), and systematic reviews of folklore use (C). There is a lack of high-level clinical trial data (A or B) to support therapeutic claims in humans.
PubMed sources
1.PMID: 30000943 (2006) — Lignans from Euphorbia hirta L. · Natural product research
2.PMID: 29849664 (2018) — Potential Use of Euphorbia hirta for Dengue: A Systematic Review of Scientific Evidence. · Journal of tropical medicine
3.PMID: 40061720 (2024) — In Silico toxicity assessment of Euphorbia hirta. · Journal of pharmacy & bioallied sciences
4.PMID: 40061658 (2024) — Determination of Phytochemical Properties "Amman Pacharisi"-Euphorbia hirta Linn. · Journal of pharmacy & bioallied sciences
5.PMID: 25598628 (2015) — Minerals salt composition and secondary metabolites of Euphorbia hirta Linn., an antihyperglycemic plant.
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
Ethanol extract formulated as a mouthwash demonstrated anti-bacterial effects against Streptococcus mutans [PMID: 35592805]
· Pharmacognosy research
6.PMID: 24359779 (2013) — Triterpenes from Euphorbia hirta and their cytotoxicity. · Chinese journal of natural medicines
7.PMID: 36268597 (2022) — Protective effect of Euphorbia thymifolia and Euphorbia hirta against carbon tetrachloride-induced hepatotoxicity in Wistar rats. · Drug development and industrial pharmacy
8.PMID: 35187071 (2021) — Phytochemicals of Euphorbia hirta L. and Their Inhibitory Potential Against SARS-CoV-2 Main Protease. · Frontiers in molecular biosciences
9.PMID: 35592805 (2022) — Formulation, characteristics and anti-bacterial effects of Euphorbia hirta L. mouthwash. · Journal of Taibah University Medical Sciences
10.PMID: 35455080 (2022) — Euphorbia hirta Leaf Ethanol Extract Suppresses TNF-α/IFN-γ-Induced Inflammatory Response via Down-Regulating JNK or STAT1/3 Pathways in Human Keratinocytes. · Life (Basel, Switzerland)
11.PMID: 39290882 (2024) — A review of ethnobotanical studies reveals over 500 medicinal plants in Mindanao, Philippines. · Plant diversity
12.PMID: 27033089 (2016) — Quercetin-3-O-rhamnoside from Euphorbia hirta protects against snake Venom induced toxicity. · Biochimica et biophysica acta
13.PMID: 28479737 (2017) — Flavonoids from whole Plant of Euphorbia hirta and their Evaluation against Experimentally induced Gastroesophageal Reflux Disease in Rats. · Pharmacognosy magazine
14.PMID: 39505796 (2025) — Flavonoids of Euphorbia hirta inhibit inflammatory mechanisms via Nrf2 and NF-κB pathways. · Cell biochemistry and biophysics
15.PMID: 28150592 (1986) — Air-borne Contact Dermatitis in Varanasi. · Indian journal of dermatology, venereology and leprology
16.PMID: 19943357 (2010) — Molluscicides from some common medicinal plants of eastern Uttar Pradesh, India. · Journal of applied toxicology : JAT
17.PMID: 17643865 (2007) — Anti-anaphylactic effect of Euphorbia hirta. · Fitoterapia