PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Ameliorated cognitive impairment and reduced amyloid-β plaques and phosphorylated tau protein deposition [PMID:39019356, 37686830]
Polysaccharides regulated intestinal microbiota and brain metabolites to exert antidepressant effects [PMID:42235777]
Bioactive metabolites such as lovastatin and ergothioneine have confirmed activity against NAFLD [PMID:41683239]
Exopolysaccharides and purified cytokinin fractions demonstrated cytotoxic activity against cancer cells, including HepG2 and colon adenocarcinoma Colo 205 cells [PMID:36277811, 33822496, 36325705]
Polysaccharides increased mean lifespan by 16.36% at high doses (500 μg/mL) [PMID:41251781]
Evidence summary
PubMed sources
- 1.PMID: 36277811 (2022) — Antioxidant activity and cytotoxicity of exopolysaccharide from mushroom Hericium coralloides in submerged fermentation. · Biomass conversion and biorefinery
- 2.PMID: 39019356 (2024) — Structural characterization of Hericium coralloides polysaccharide and its neuroprotective function in Alzheimer's disease. · International journal of biological macromolecules
- 3.PMID: 41683239 (2026) — Dietary Use of Hericium coralloides for NAFLD Prevention. · Nutrients
- 4.PMID: 35584030 (2022) — Influence of rutin on fruiting of Hericium coralloides, Polyporus umbellatus, and Flammulina velutipes. · Mycologia
- 5.PMID: 39452656 (2024) — Chromosome-Scale Genome and Transcriptomic Analyses Reveal Differential Regulation of Terpenoid Secondary Metabolites in Hericium coralloides.