PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Pubescenoside C and Pubescenoside D demonstrate cardioprotective effects and reduce myocardial infarction in animal and in vitro models [PMID:39357647, PMID:39916296].
Ilex pubescens is a component of traditional formulas (Jin-Xin-Kang and Xinyin tablets) used to alleviate CHF by modulating mitochondrial function and the HDAC3-mediated PINK1/Parkin signaling pathway [PMID:39127116, PMID:40122315].
Pubescenoside A reduces disease activity index, ameliorates colorectal stenosis, and suppresses pro-inflammatory factors via Keap1 targeting in mice [PMID:40849001].
Ilex pubescens demonstrates vascular protective effects and improves plasma coagulation parameters in rat models [PMID:38763010].
Jasurolignoside attenuates inflammatory symptoms by binding to TLR4 in vitro and in vivo [PMID:40976624].
Evidence summary
PubMed sources
- 1.PMID: 39357647 (2025) — Pharmacological upregulation of macrophage-derived itaconic acid by pubescenoside C attenuated myocardial ischemia-reperfusion injury. · Journal of advanced research
- 2.PMID: 42143464 (2026) — Triterpene saponin from Ilex pubescens attenuates ferroptosis in myocardial ischemia/reperfusion injury by inhibiting the lncRNA Hmga2-as1/Sox10/GPX4 axis. · Phytomedicine : international journal of phytotherapy and phytopharmacology
- 3.PMID: 39127116 (2024) — Jin-Xin-Kang alleviates heart failure by mitigating mitochondrial dysfunction through the Calcineurin/Dynamin-Related Protein 1 signaling pathway. · Journal of ethnopharmacology
- 4.PMID: 31401319 (2019) — Botany, traditional uses, phytochemistry, pharmacology and toxicology of Ilex pubescens Hook et Arn. · Journal of ethnopharmacology
- 5.PMID: 25082209