PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Aqueous leaf extract significantly reduced blood glucose in glucose-loaded, normal, and streptozotocin-induced hyperglycemic rats, although it was less effective than glibenclamide [PMID:20431805].
Hydroalcoholic extract of the root demonstrated dose-dependent anti-nociceptive, locomotor depressant, muscle relaxant, and sedative potentiating effects in experimental animal models [PMID:23787183].
Fruit aqueous extract reduced lipid peroxidation and increased antioxidant enzyme activities in diabetic rats [PMID:20072924].
Methanol extracts of pointed gourd showed moderate cytotoxicity in HeLa cells [PMID:38213720].
Evidence summary
PubMed sources
- 1.PMID: 22654406 (2012) — Trichosanthes dioica Roxb.: An overview. · Pharmacognosy reviews
- 2.PMID: 40854661 (2025) — Unravelling genetic diversity in pointed gourd (Trichosanthes dioica) genotypes from India's Eastern plateau and hill region: Insights from morphological and molecular markers. · Journal, genetic engineering & biotechnology
- 3.PMID: 40845282 (2025) — Exploring Trichosanthes dioica: A Comprehensive Study of Its Ethnomedical Uses, Phytochemistry, Pharmacology and Toxicity. · Chemistry & biodiversity
- 4.PMID: 20431805 (2010) — Hypoglycemic effect of aqueous extract of Trichosanthes dioica in normal and diabetic rats. · International journal of diabetes in developing countries
- 5.PMID: 38213720 (2024)