This product is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before using herbs, especially if you are pregnant, nursing, taking medications, or have a medical condition.
PubMed · Distribution, Phytochemical Insights, and Cytotoxic Potential of the <i>Sesbania</i> Genus: A Comprehensive Review of <i>Sesbania grandiflora</i>, <i>Sesbania sesban</i>, and <i>Sesbania cannabina</i>. (2025)
PubMed · Effective inhibition of Sesbania grandiflora bioactive compounds against C-di-GMP phosphodiesterase of Pseudomonas aeruginosa. (2024)
Reviewed by: HerbAlly Editorial Team, Medical herbalists and healthcare professionals
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Sesbania grandiflora, also known as the hummingbird tree, is a medicinal plant used in traditional Indian and Myanmar medicine for its diverse pharmacological properties [PMID:21251969, PMID:30650546].
Background
Sesbania grandiflora (Fabaceae) is a plant commonly referred to as 'Sesbania', 'agathi', or 'hummingbird tree' [PMID:21251969, PMID:29530609]. It is an edible medicinal plant utilized in Ayurvedic, Siddha, and other traditional medicine systems in India, Sri Lanka, and Myanmar [PMID:21251969, PMID:31263504, PMID:30650546, PMID:35813364].
Traditional uses
In folk and traditional medicines, it is used to treat headache, swellings, anemia, bronchitis, pains, liver disorders, tumors [PMID:21251969], inflammation, colitis, diarrhea, dysentery, leprosy, gout, rheumatism, jaundice, convulsion, anxiety [PMID:29530609], and renal calculi [PMID:18408896]. It is also historically employed for the management of diabetes mellitus and associated cognitive decline [PMID:40484255].
Active compounds
The plant contains flavonoids, alkaloids [PMID:39861127], polyphenols, and flavanones [PMID:29530609]. Specific identified compounds include quercetin, kaempferol, sesbagrandiforian A and B [PMID:39861127], sesbanimides (from seeds) [PMID:39861127], a glycosylated oleanolic acid derivative (F4B1) [PMID:40468424], and 2-arylbenzofurans such as sesbagrandiflorain D and E, spinosan A, and spinosan B [PMID:32945195]. Flowers contain alpha-glucosidase inhibitor proteins SGF60 and SGF90 [PMID:17823874].
Mechanism of action
Anticancer effects are attributed to the activation of caspase cascades and induction of apoptosis [PMID:39861127]; specifically, sesbanimides disrupt mitochondrial function [PMID:39861127] and the derivative F4B1 suppresses NF-κB translocation to induce intrinsic apoptosis in lung adenocarcinoma cells [PMID:40468424]. Anti-inflammatory effects in ulcerative colitis are mediated by the inhibition of TNF-α and IL-6 [PMID:29530609].
Clinical evidence
Evidence DCancer
Ethanol extracts of leaves and flowers showed anticancer activity against Ehrlich ascites carcinoma in mice [PMID:21251969]; 2-arylbenzofurans showed cytotoxicity against MCF-7, HeLa, and WiDr cells [PMID:32945195]; flowers showed anticancer properties against various cell models [PMID:31263504].
Evidence DDiabetes Mellitus
Flower extract (250 mg/kg) in diabetic rats lowered glucose and HbA1C levels and ameliorated C-peptide, insulin, and carbohydrate metabolic enzyme activities [PMID:34220217].
Evidence DUlcerative Colitis
Hydroalcoholic extract (100 and 200 mg/kg) provided a protective effect against acetic acid-induced ulcerative colitis in mice [PMID:29530609].
Evidence DHepatotoxicity
Ethanolic leaf extract (200 mg/kg/day) produced significant hepatoprotection against erythromycin estolate-induced hepatotoxicity in rats [PMID:14682193].
Evidence DBacterial Infections
Stem bark extracts exhibited antibacterial activity, particularly the butanol fraction against Gram-negative bacteria [PMID:22466091]; extracts also showed anti-biofilm and antibacterial activity against Staphylococcus aureus [PMID:29090281].
Evidence summary
The current evidence is based primarily on in vitro studies and animal models (Level D), demonstrating potential anticancer, anti-diabetic, hepatoprotective, and antibacterial activities. No human clinical trials were provided.
PubMed sources
1.PMID: 21251969 (2011) — Evaluation of anticancer activity of ethanol extract of Sesbania grandiflora (Agati Sesban) against Ehrlich ascites carcinoma in Swiss albino mice. · Journal of ethnopharmacology
2.PMID: 40484255 (2025) — Interlinking diabetes and Alzheimer's disease: A pathway through medicinal plant-based treatments. · Journal of ethnopharmacology
3.PMID: 39861127 (2025) — Distribution, Phytochemical Insights, and Cytotoxic Potential of the Sesbania Genus: A Comprehensive Review of Sesbania grandiflora, Sesbania sesban, and Sesbania cannabina. · Pharmaceuticals (Basel, Switzerland)
4.PMID: 31263504 (2019) — Medicinally Important Herbal Flowers in Sri Lanka. · Evidence-based complementary and alternative medicine : eCAM
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
— Protective effect of Sesbania grandiflora on acetic acid induced ulcerative colitis in mice by inhibition of TNF-α and IL-6.
· Journal of ethnopharmacology
6.PMID: 22466091 (2011) — Antibacterial activities of Sesbania grandiflora extracts. · Drug discoveries & therapeutics
7.PMID: 37432639 (2024) — Green Synthesising ZnO Nanoparticle Using Sesbania grandiflora and Their Evaluation of Anti-diabetic Anti-advanced Glycation End Products and Cytotoxic Effects. · Applied biochemistry and biotechnology
8.PMID: 14682193 (2003) — Protective effect of Sesbania grandiflora against erythromycin estolate-induced hepatotoxicity. · Therapie
9.PMID: 40468424 (2025) — A Naturally Derived Glycosylated Oleanolic Acid Derivative Suppresses NF-κB Translocation and Induces Intrinsic Apoptosis in Lung Adenocarcinoma Cells. · Chemical biology & drug design
10.PMID: 30650546 (2019) — A Review on the Phytochemistry, Medicinal Properties and Pharmacological Activities of 15 Selected Myanmar Medicinal Plants. · Molecules (Basel, Switzerland)
11.PMID: 32945195 (2021) — Two new 2-arylbenzofurans from Sesbania grandiflora L. and their cytotoxicity towards cancer cell. · Natural product research
12.PMID: 18408896 (2008) — Evaluation of Sesbania grandiflora for antiurolithiatic and antioxidant properties. · Journal of natural medicines
13.PMID: 29090281 (2017) — In vitro anti- biofilm and anti-bacterial activity of Sesbania grandiflora extract against Staphylococcus aureus. · Biochemistry and biophysics reports
15.PMID: 39243548 (2024) — Hepatoprotective effect of flavonoid rich fraction of Sesbania grandiflora: Results of In vivo, in vitro, and molecular docking studies. · Journal of Ayurveda and integrative medicine
16.PMID: 35813364 (2020) — Phenolic composition, antioxidant and anti-fibrotic effects of Sesbania grandiflora L. (Agastya) - An edible medicinal plant. · Ayu
17.PMID: 28458298 (2017) — Biological activities and antibacterial biomarker of Sesbania grandiflora bark extract. · Drug discoveries & therapeutics
18.PMID: 34220217 (2021) — Ameliorative property of Sesbania grandiflora on carbohydrate metabolic enzymes in the liver and kidney of streptozotocin-induced diabetic rats. · Saudi journal of biological sciences