PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Hydroalcoholic and n-BuOH extracts showed in vitro antifungal activity against C. albicans and C. glabrata; in vivo rat models demonstrated activity against azole-susceptible and resistant species [PMID:21542936, PMID:26007191].
A hydroalcoholic extract of pericarps (ETHOSS) demonstrated in vitro antifungal activity against Trichophyton rubrum, T. mentagrophytes, and T. interdigitale, with the ability to permeate human nails [PMID:33466379].
An observational study of dogs with cutaneous leishmaniasis evaluated a topical ointment containing 2% hederagenin glucoside saponins and 2% chromane-derived hydrazone [PMID:35179617].
Saponin fractions (SAP1, SAP2) from fruit pericarp showed cytotoxic activity against CaCo2 cell lines [PMID:37194675]. Synthetic derivatives of hederagenin demonstrated potent antitumor activity across various human cancer cell lines [PMID:30840925, PMID:27017553, PMID:26476750].
S. saponaria oil promotes cell proliferation, cell migration, and stimulates skin wound-healing effects [PMID:38999621].
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 38999621 (2024) — The Biosynthesis Pattern and Transcriptome Analysis of Sapindus saponaria Oil. · Plants (Basel, Switzerland)
- 2.PMID: 40692410 (2025) — Strong and Stiff Sapindus saponaria Seed Shell with Gradient Structure. · Small (Weinheim an der Bergstrasse, Germany)
- 3.PMID: 33932515 (2021) — In vitro biochemical characterization and genotoxicity assessment of Sapindus saponaria seed extract. · Journal of ethnopharmacology
- 4.PMID: 27819730 (2016) — Rhizosphere bacteriome of the medicinal plant Sapindus saponaria L. revealed by pyrosequencing. · Genetics and molecular research : GMR
- 5.PMID: 41771795 (2026) — Extract of Sapindus saponaria L., a Native Amazonian Plant, Impacts Germ Cell Development and Modulates Longevity.