PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 29 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Meta-analysis of preclinical studies showed significant differences in blood glucose levels (BGL) between intervention and control groups at doses of 200, 300, and 400 mg/kg of stevia leaves [PMID:36171777].
Systematic review and meta-analysis of experimental rat models indicate stevia leaf extracts or glycosides attenuate oxidative stress markers [PMID:37571265].
Reviews suggest anti-hypertensive and hypotensive properties, though some results are noted as equivocal [PMID:34803554, PMID:30000908, PMID:36770924].
Literature reviews report antitumor and anti-cancer activities studied in in vitro and in vivo models [PMID:35209150, PMID:36770924].
Stevia treatment (400 mg/kg) significantly increased body and testis weight in streptozotocin-induced diabetic mice [PMID:37415512].
Safety & adverse effects
Pregnancy & lactation
Evidence summary
PubMed sources
- 1.PMID: 34803554 (2021) — Natural sweetener Stevia rebaudiana: Functionalities, health benefits and potential risks. · EXCLI journal
- 2.PMID: 32031079 (2020) — Stevia as a Natural Sweetener: A Review. · Cardiovascular & hematological agents in medicinal chemistry
- 3.PMID: 17744732 (1968) — Contraceptive Properties of Stevia rebaudiana. · Science (New York, N.Y.)
- 4.PMID: 30000908 (2006) — Stevioside. · Phytochemistry
- 5.PMID: 36770924 (2023) — Steviol Glycosides from Stevia rebaudiana: An Updated Overview of Their Sweetening Activity, Pharmacological Properties, and Safety Aspects. · Molecules (Basel, Switzerland)