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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Strobilanthes crispus is a medicinal herb native to Malaysia and the Malay Archipelago, traditionally used for cancer, diabetes, and immune system support [PMID:36046107, PMID:33127562, PMID:20684795].
Background
Strobilanthes crispus (Acanthaceae family), also known as Batuzin, Bayam Karang, Kotz Bellin, Pekka Batu, Pecah kaca, or Jin batu, is a plant native to Malaysia [PMID:36046107, PMID:30594607, PMID:33127562].
Traditional uses
Traditionally used for the treatment of cancer, gastrointestinal disorders, inflammatory wounds of snake bites, kidney stones, diabetes, hypertension, and to boost the immune system [PMID:30594607, PMID:33127562, PMID:29100935, PMID:27844243]. It has also been used as a diuretic, antilytic, and laxative [PMID:16688478, PMID:22471785].
Active compounds
Identified constituents include lutein, β-sitosterol, and stigmasterol [PMID:33127562, PMID:33906591]. Other reported metabolites include indolo-quinazoline alkaloids, flavonoids, phenolic acids, sterols, terpenoids, tannins, caffeine, and α-linolenic acid [PMID:42005722, PMID:11137889, PMID:30970652].
Mechanism of action
The herb's bioactive subfraction F3 inhibits breast cancer metastasis by affecting markers such as E-cadherin, MMP-9, MUC-1, N-cadherin, Twist, VEGF, and vimentin [PMID:30594607]. It exhibits anti-glycolytic activity by inhibiting the localization of GLUT1 to the cell membrane via reduction in PKC activity and increased TXNIP protein expression [PMID:37259304]. It may induce apoptosis through the mitochondria-dependent p53 pathway [PMID:22471785] or by suppressing BCL-2 protein expression [PMID:33511882]. Additionally, it stimulates anti-tumor immunogenicity by increasing MHC class I and II molecules and infiltrating CD4+, CD8+, and IL-2+ cells into the tumor microenvironment [PMID:35972917].
Clinical evidence
Evidence DBreast Cancer
Bioactive subfraction F3 inhibited tumor progression, migration, and metastasis in 4T1-induced mouse mammary carcinoma models [PMID:30594607, PMID:33127562].
Evidence DColon Cancer
Ethanol extract significantly inhibited colorectal carcinogenesis and reduced aberrant crypt foci (ACF) in rats [PMID:26307342, PMID:26608653].
Evidence DHyperglycemia
Hot water extracts of fermented and unfermented tea reduced blood glucose in streptozotocin-induced hyperglycemic rats [PMID:16688478].
Evidence DHepatocellular Carcinoma
Juice concentrations above 0.1% induced apoptosis and DNA damage in HepG2 cell lines [PMID:26320494].
Safety & adverse effects
A 14-day subacute oral toxicity study in rats using ethanol leaf extracts (up to 600 mg/kg) did not cause significant changes in body weight, food consumption, or liver and kidney function parameters [PMID:23593574].
Drug interactions
The bioactive subfraction F3 exhibited relatively weak inhibition of CYP2B6, CYP2C19, CYP2D6, and CYP3A4 enzymes [PMID:35146636].
Evidence summary
The current evidence is primarily based on in vitro cell lines and in vivo animal models (predominantly rats and mice), indicating promising anticancer, antihyperglycemic, and antioxidant properties; however, there are no human clinical trials provided.
PubMed sources
1.PMID: 36046107 (2022) — The complete chloroplast genome of Strobilanthes crispus (Acanthaceae). · Mitochondrial DNA. Part B, Resources
2.PMID: 30594607 (2019) — Strobilanthes crispus inhibits migration, invasion and metastasis in breast cancer. · Journal of ethnopharmacology
3.PMID: 33127562 (2021) — Strobilanthes crispus bioactive subfraction inhibits tumor progression and improves hematological and morphological parameters in mouse mammary carcinoma model. · Journal of ethnopharmacology
4.PMID: 35972917 (2022) — Strobilanthes crispus elicits anti-tumor immunogenicity in in vitro and in vivo metastatic breast carcinoma. · PloS one
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
— Advances on Ethnobotanical, Phytochemical, and Preclinical Studies of Strobilanthes crispus and Strobilanthes cusia (Acanthaceae) for Drug Development Purpose: A Narrative Review.
· Journal of experimental pharmacology
6.PMID: 35268823 (2022) — Wound Healing, Antimicrobial and Antioxidant Properties of Clinacanthus nutans (Burm.f.) Lindau and Strobilanthes crispus (L.) Blume Extracts. · Molecules (Basel, Switzerland)
7.PMID: 33906591 (2022) — Antiglycolytic Activities of Strobilanthes crispus Active Fraction and its Bioactive Components on Triple-Negative Breast Cancer Cells In Vitro. · Anti-cancer agents in medicinal chemistry
8.PMID: 37847252 (2023) — Green synthesis, characterisation and antibacterial activities of Strobilanthes crispus-mediated silver nanoparticles (SC-AGNPS) against selected bacteria. · Artificial cells, nanomedicine, and biotechnology
9.PMID: 33511882 (2022) — Stem Hexane Extract of Strobilanthes crispus Induces Apoptosis in Triple-Negative Breast Cancer Cell Line. · Nutrition and cancer
10.PMID: 35146636 (2022) — Inhibition of Cytochrome P450s by Strobilanthes crispus Sub-Fraction (F3): Implication for Herb-Drug Interaction. · European journal of drug metabolism and pharmacokinetics
11.PMID: 20376534 (2010) — Strobilanthes crispus attenuates renal carcinogen, iron nitrilotriacetate (Fe-NTA)-mediated oxidative damage of lipids and DNA. · Molecular and cellular biochemistry
12.PMID: 37259304 (2023) — Regulatory Mechanism on Anti-Glycolytic and Anti-Metastatic Activities Induced by Strobilanthes crispus in Breast Cancer, In Vitro. · Pharmaceuticals (Basel, Switzerland)
13.PMID: 30914878 (2018) — Strobilanthes crispus Extract Reduces Respiratory Exchange Ratio in Obese Mice Fed High Fat and Low Fat Diets. · The Malaysian journal of medical sciences : MJMS
14.PMID: 26608653 (2015) — Evaluation of chemopreventive potential of Strobilanthes crispus against colon cancer formation in vitro and in vivo. · BMC complementary and alternative medicine
15.PMID: 26307342 (2015) — Chemopreventive effects of Strobilanthes crispus leaf extract on azoxymethane-induced aberrant crypt foci in rat colon. · Scientific reports
16.PMID: 29100935 (2018) — Immunomodulatory effects of a bioactive fraction of Strobilanthes crispus in NMU-induced rat mammary tumor model. · Journal of ethnopharmacology
17.PMID: 37561949 (2023) — Optimization of total phenolic content, total flavonoid content and anti-gout properties of polyherbal formulation. · Journal of complementary & integrative medicine
18.PMID: 30970652 (2019) — Antioxidant Activity, and Volatile and Phytosterol Contents of Strobilanthes crispus Dehydrated Using Conventional and Vacuum Microwave Drying Methods. · Molecules (Basel, Switzerland)
19.PMID: 23593574 (2012) — Subacute oral toxicity study of ethanolic leaves extracts of Strobilanthes crispus in rats. · Asian Pacific journal of tropical biomedicine
20.PMID: 20112179 (2010) — Anti-angiogenic and cytotoxicity studies of some medicinal plants. · Planta medica
21.PMID: 26320494 (2015) — Strobilanthes crispus Juice Concentrations and Anticancer Effects on DNA Damage, Apoptosis and Gene Expression in Hepatocellular Carcinoma Cells. · Asian Pacific journal of cancer prevention : APJCP
22.PMID: 16688478 (2006) — Effects of Strobilanthes crispus tea aqueous extracts on glucose and lipid profile in normal and streptozotocin-induced hyperglycemic rats. · Plant foods for human nutrition (Dordrecht, Netherlands)
23.PMID: 11137889 (2000) — Chemical composition and antioxidant activity of Strobilanthes crispus leaf extract. · The Journal of nutritional biochemistry
24.PMID: 24862048 (2014) — Antitrypanosomal screening and cytotoxic effects of selected medicinal plants. · Tropical biomedicine
25.PMID: 26613959 (2015) — Phytochemical constituents and biological activities of different extracts of Strobilanthes crispus (L.) Bremek leaves grown in different locations of Malaysia. · BMC complementary and alternative medicine
26.PMID: 23022321 (2012) — Hypoxia affects cellular responses to plant extracts. · Journal of ethnopharmacology
27.PMID: 25058874 (2014) — Ethnobotanical survey of usage of fresh medicinal plants in Singapore. · Journal of ethnopharmacology
28.PMID: 27844243 (2017) — Analysis of chemical constituents, antimicrobial and anticancer activities of dichloromethane extracts of Sordariomycetes sp. endophytic fungi isolated from Strobilanthes crispus. · World journal of microbiology & biotechnology
29.PMID: 22471785 (2012) — In vitro cytotoxicity of Strobilanthes crispus ethanol extract on hormone dependent human breast adenocarcinoma MCF-7 cell. · BMC complementary and alternative medicine
30.PMID: 20684795 (2010) — Anticancer activity of a sub-fraction of dichloromethane extract of Strobilanthes crispus on human breast and prostate cancer cells in vitro. · BMC complementary and alternative medicine