PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Administration of crude powder or extracts at 3 g/kg showed a significant reduction in eggs per gram of faeces [PMID:16815639]
Xanthones from S. chirata, specifically 1,5,8-trihydroxy-3-methoxyxanthone (TMX), demonstrated cytotoxic and anti-metastatic potential against breast adenocarcinoma frameworks [PMID:33107489, PMID:33112542]
Methanol extracts provided protection (up to 81%) against paracetamol and galactosamine-induced hepatotoxicity [PMID:10190179]
As part of the polyherbal formulation Ayush-64, S. chirata showed immunomodulatory potential, although it did not limit the lung viral load on its own [PMID:37765142]
Dichloromethane fractions showed significant antimicrobial activity, particularly against Staphylococcus aureus [PMID:20387750]
Drug interactions
Evidence summary
PubMed sources
- 1.PMID: 29076426 (2017) — Swertia chirata: A Comprehensive Review with Recent Advances. · Current pharmaceutical biotechnology
- 2.PMID: 30210007 (2019) — Amarogentin as Topical Anticancer and Anti-Infective Potential: Scope of Lipid Based Vesicular in its Effective Delivery. · Recent patents on anti-infective drug discovery
- 3.PMID: 21338178 (2010) — Highlighting the anti-carcinogenic potential of an ayurvedic medicinal plant, Swertia Chirata. · Asian Pacific journal of cancer prevention : APJCP
- 4.PMID: 39318902 (2024) — Anti-inflammatory and Antioxidant Activity of Neem and Kirata-Induced Silver Nanoparticles Against Oral Biofilm: An In Vitro Study. · Cureus
- 5.PMID: 34381094 (2021) — Optimization of harvest and extraction factors by full factorial design for the improved yield of C-glucosyl xanthone mangiferin from Swertia chirata.