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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Swertia chirata is an ethnomedicinal plant used in traditional systems like Ayurveda for its diverse therapeutic properties, including anti-inflammatory, antioxidant, and anticancer activities [PMID:29076426, PMID:21338178].
Background
Swertia chirata (also known as Chirayata in India) is a bitter-tasting plant belonging to the Gentianaceae family [PMID:30210007, PMID:39318902].
Traditional uses
In Ayurveda, it is used as a stomachic, febrifuge, antihelminthic, diuretic, and for the treatment of mental disorders [PMID:21338178]. It is also used in folk medicine for constipation, colic, diarrhea, asthma, chronic fever, malaria, liver disorders, and diabetes [PMID:29076426, PMID:21792726].
Active compounds
Active phytochemicals include bitter secoiridoids (gentiopicroside, amarogentin, swertiamarin, isovitexin, and isogentisin) [PMID:30210007], xanthones (including 1,5,8-trihydroxy-3-methoxyxanthone and mangiferin) [PMID:33107489, PMID:33112542], and pentacyclic triterpenoids such as ursolic acid [PMID:26657265, PMID:29492371].
Mechanism of action
The plant exhibits antioxidant and anti-inflammatory activities [PMID:21338178, PMID:39318902]. It has been shown to activate detoxification enzymes (GST, GPx, SOD, and CAT) and reduce lipid peroxidation [PMID:15173996]. In isolated tissues, it demonstrates modulatory effects on the gut and airways, including the relaxation of carbachol-induced contractions in the trachea and inhibition of high K(+)-induced contractions in the jejunum, similar to verapamil [PMID:21792726].
Clinical evidence
Evidence BGastrointestinal Nematodes (Sheep)
Administration of crude powder or extracts at 3 g/kg showed a significant reduction in eggs per gram of faeces [PMID:16815639]
Evidence DBreast Cancer (In vitro/In vivo)
Xanthones from S. chirata, specifically 1,5,8-trihydroxy-3-methoxyxanthone (TMX), demonstrated cytotoxic and anti-metastatic potential against breast adenocarcinoma frameworks [PMID:33107489, PMID:33112542]
Evidence DHepatotoxicity (Rats)
Methanol extracts provided protection (up to 81%) against paracetamol and galactosamine-induced hepatotoxicity [PMID:10190179]
Evidence DCOVID-19 (Hamster Model)
As part of the polyherbal formulation Ayush-64, S. chirata showed immunomodulatory potential, although it did not limit the lung viral load on its own [PMID:37765142]
A study on rat liver microsomes investigated the inhibition potential of S. chirata extract and ursolic acid on hepatic drug metabolizing isozymes CYP3A4 and CYP2D6 [PMID:26657265].
Evidence summary
The evidence consists primarily of in vitro studies, animal models (rats, mice, sheep, hamsters), and literature reviews. There is a lack of human clinical trial data in the provided set.
PubMed sources
1.PMID: 29076426 (2017) — Swertia chirata: A Comprehensive Review with Recent Advances. · Current pharmaceutical biotechnology
2.PMID: 30210007 (2019) — Amarogentin as Topical Anticancer and Anti-Infective Potential: Scope of Lipid Based Vesicular in its Effective Delivery. · Recent patents on anti-infective drug discovery
3.PMID: 21338178 (2010) — Highlighting the anti-carcinogenic potential of an ayurvedic medicinal plant, Swertia Chirata. · Asian Pacific journal of cancer prevention : APJCP
4.PMID: 39318902 (2024) — Anti-inflammatory and Antioxidant Activity of Neem and Kirata-Induced Silver Nanoparticles Against Oral Biofilm: An In Vitro Study. · Cureus
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
— Optimization of harvest and extraction factors by full factorial design for the improved yield of C-glucosyl xanthone mangiferin from Swertia chirata.
· Scientific reports
6.PMID: 33107489 (2020) — Therapeutic potential of xanthones from Swertia chirata in breast cancer cells. · The Indian journal of medical research
7.PMID: 26657265 (2016) — CYP450 mediated inhibition potential of Swertia chirata: An herb from Indian traditional medicine. · Journal of ethnopharmacology
8.PMID: 31076338 (2019) — Viral protein R inhibitors from Swertia chirata of Myanmar. · Journal of bioscience and bioengineering
9.PMID: 37765142 (2023) — Evaluation of Ayush-64 (a Polyherbal Formulation) and Its Ingredients in the Syrian Hamster Model for SARS-CoV-2 Infection Reveals the Preventative Potential of Alstonia scholaris. · Pharmaceuticals (Basel, Switzerland)
10.PMID: 15173996 (2004) — Evaluation of the anticarcinogenic activity of Swertia chirata Buch.Ham, an Indian medicinal plant, on DMBA-induced mouse skin carcinogenesis model. · Phytotherapy research : PTR
11.PMID: 16815639 (2006) — Anthelmintic activity of Swertia chirata against gastrointestinal nematodes of sheep. · Fitoterapia
12.PMID: 10190179 (1999) — Antihepatotoxic activity of Swertia chirata on paracetamol and galactosamine induced hepatotoxicity in rats. · Phytotherapy research : PTR
13.PMID: 21792726 (2012) — Insights into mechanisms underlying the gut and airways modulatory effects of Swertia chirata. · Journal of natural medicines
14.PMID: 19140153 (2009) — Assessment of systemic interaction between Swertia chirata extract and its Bioactive constituents in rabbits. · Phytotherapy research : PTR
15.PMID: 29492371 (2018) — Optimization of extraction parameters of pentacyclic triterpenoids from Swertia chirata stem using response surface methodology. · 3 Biotech
16.PMID: 33112542 (2020) — Anti-Metastatic Potential of a Novel Xanthone Sourced by Swertia chirata Against In Vivo and In Vitro Breast Adenocarcinoma Frameworks. · Asian Pacific journal of cancer prevention : APJCP
17.PMID: 20387750 (2009) — In vitro antimicrobial activities of different fractions of Swertia chirata ethanolic extract. · Pakistan journal of biological sciences : PJBS