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Valeriana officinalis
Valerian is a perennial flowering plant native to Europe and Asia, long valued for its sedative and anxiolytic properties. It has been used since ancient Greek and Roman times for insomnia and nervousness. The root is the primary medicinal part, known for its distinctive strong odor.
| Drug | Severity | Description |
|---|---|---|
| Diazepam (Valium) | severe | Valerian may enhance the sedative effects of benzodiazepines, causing excessive drowsiness, respiratory depression, and impaired motor function. |
| Lorazepam (Ativan) | severe | Combining valerian with lorazepam increases risk of excessive sedation and CNS depression. |
| Zolpidem (Ambien) | moderate | Valerian may enhance sedative effects of zolpidem, increasing drowsiness and next-day impairment. |
| Alcohol | moderate | Valerian combined with alcohol may cause additive CNS depression, increasing drowsiness and impaired coordination. |
| Alprazolam (Xanax) | severe | Concurrent use of valerian and alprazolam may lead to excessive sedation and respiratory depression. |