PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Witch hazel is described as an effective and well-tolerated treatment for diaper dermatitis [PMID:28300437]. A randomized trial compared a cream containing 12 mg/100 g of H. virginiana to breast milk for healing in infants [PMID:41468068].
Witch hazel has shown beneficial therapeutic effects on pain, bleeding, and swelling associated with hemorrhoids [PMID:40458338].
A propylene glycol-free, witch hazel-based solution of 5% minoxidil sulfate was evaluated for efficacy and safety in patients who failed to respond to standard minoxidil [PMID:38179008].
A witch hazel-based shampoo and tonic were reported by patients to improve subjective manifestations of irritation with good to excellent tolerance [PMID:25210333].
In human keratinocyte models, bark extract inhibited the release of mediators involved in skin autoimmunity (IL-6, IL-17C) and allergy (TSLP, CCL26, MMP-9) [PMID:36012541].
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 40819781 (2025) — Chemical composition, skin microbiota metabolism, antimicrobial potential and anti-inflammatory properties of witch hazel bark (Hamamelis virginiana L.). · Journal of ethnopharmacology
- 2.PMID: 36012541 (2022) — Unveiling the Ability of Witch Hazel (Hamamelis virginiana L.) Bark Extract to Impair Keratinocyte Inflammatory Cascade Typical of Atopic Eczema. · International journal of molecular sciences
- 3.PMID: 38179008 (2023) — Efficacy, Tolerability, and Superiority of Propylene Glycol-Free, North American Witch-Hazel (Hamamelis virginiana)-Based Solution of 5% Minoxidil Sulfate for the Treatment of Female Androgenetic Alopecia. · International journal of trichology
- 4.PMID: 40649262 (2025) — Hamamelis virginiana L. in Skin Care: A Review of Its Pharmacological Properties and Cosmetological Applications. · Molecules (Basel, Switzerland)
- 5.PMID: 35740016