PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 4 PubMed articles · model: gemma4:31b
Summary
Zao Jiao Ci (ZJC), the spine of Gleditsia sinensis, is a traditional Chinese medicine used for its anti-inflammatory and various other medicinal properties [PMID:27401288, PMID:27433183].
Background
Zao Jiao Ci (ZJC) is the spine of the Chinese Honey locust (Gleditsia sinensis Lam.) [PMID:27401288].
Traditional uses
In China, it has been traditionally used for anticancer, detoxication, detumescence, apocenosis, antiparasite effects, and to reduce inflammation [PMID:27401288, PMID:27433183].
Active compounds
The herb contains bioactive phytochemicals, including soluble sugars and starch, though specific chemical constituents are mentioned as being reported in literature without being listed individually in the provided abstracts [PMID:37050082, PMID:27433183].
Mechanism of action
ZJC aqueous extract demonstrates anti-inflammatory effects by decreasing the expression of cyclooxygenase (COX)-2 and reducing the production of prostaglandin E2 (PGE2) and nitric oxide [PMID:27401288].
Clinical evidence
Evidence DInflammation (Animal Model)
Aqueous extract of ZJC at 100mg/kg showed a significant suppressive effect on carrageenan-induced paw edema in rats [PMID:27401288].
Evidence DLaryngeal Squamous Cell Carcinoma (LSCC)
Network pharmacology and bioinformatics suggest ZJC is a promising candidate for treating LSCC, though molecular mechanisms are still being explored [PMID:34257654].
Evidence summary
The current evidence is primarily based on in vitro studies, animal models, and bioinformatics analysis; there is a lack of human clinical trial data in the provided abstracts.
PubMed sources
- 1.PMID: 37050082 (2023) — Comparative Transcriptome Analysis of Gleditsia sinensis Thorns at Different Stages of Development. · Plants (Basel, Switzerland)
- 2.PMID: 27401288 (2016) — In vivo and in vitro anti-inflammatory effects of Zao-Jiao-Ci (the spine of Gleditsia sinensis Lam.) aqueous extract and its mechanisms of action. · Journal of ethnopharmacology
- 3.PMID: 34257654 (2021) — Network Pharmacology and Bioinformatics Methods Reveal the Mechanism of Zao-Jiao-Ci in the Treatment of LSCC. · Journal of oncology
- 4.PMID: 27433183 (2016) — From Traditional Usage to Pharmacological Evidence: A Systematic Mini-Review of Spina Gleditsiae. · Evidence-based complementary and alternative medicine : eCAM