PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Viola yedoensis Makino formula (VYAC) alleviates DNCB-induced atopic dermatitis by promoting M2 macrophage polarization and activating JAK2/STAT3 signaling [PMID:35689898, PMID:34332065].
Liposoluble fraction (PEVY) significantly decreased lung wet-to-dry weight ratio and attenuated lung injury in LPS-induced mouse models [PMID:22928831].
Exosome-like nanovesicles (VDNPs) in a bioadhesive hydrogel promote healing via NF-κB downregulation and M2 macrophage polarization [PMID:40751487].
A combination of V. yedoensis and Leonurus japonicus significantly reduced IL-1β in animal models [PMID:41002185].
n-Butanol extract reduced ALT, AST, and MDA levels in ConA-induced mice and inhibited HBV DNA replication in vitro [PMID:33929783].
Evidence summary
PubMed sources
- 1.PMID: 35689898 (2022) — Viola yedoensis Makino formula alleviates DNCB-induced atopic dermatitis by activating JAK2/STAT3 signaling pathway and promoting M2 macrophages polarization. · Phytomedicine : international journal of phytotherapy and phytopharmacology
- 2.PMID: 40751487 (2025) — Viola Yedoensis Makino-Derived Exosome-Like Nanovesicles-Loaded Adhesive Promotes Diabetic Fracture Healing via Anti-Inflammatory Properties. · Advanced healthcare materials
- 3.PMID: 40363729 (2025) — A Comprehensive Review of the Phytochemistry and Therapeutic Efficacy of Viola yedoensis Makino. · Molecules (Basel, Switzerland)
- 4.PMID: 22529049 (2013) — Collagenase inhibitors from Viola yedoensis. · Journal of natural medicines
- 5.PMID: 25562805