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Moderate· limited-evidence
May be possible under supervision — talk to your prescriber or pharmacist before combining.
Nettle's diuretic effect may increase lithium concentration by reducing lithium excretion, risking toxicity.
Increased renal sodium excretion from nettle's diuretic effect may reduce lithium clearance, elevating serum levels.
Source: Natural Medicines Database · Reviewed April 2026
Nettle + Lithium: use caution. May be possible under supervision — talk to your prescriber or pharmacist before combining. Nettle's diuretic effect may increase lithium concentration by reducing lithium excretion, risking toxicity.
Increased renal sodium excretion from nettle's diuretic effect may reduce lithium clearance, elevating serum levels.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.