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Moderate· limited-evidence
May be possible under supervision — talk to your prescriber or pharmacist before combining.
Horse chestnut's diuretic effects may reduce lithium excretion and increase serum levels.
Diuretic activity may reduce renal lithium clearance, elevating plasma concentrations.
Source: Natural Medicines Database · Reviewed April 2026
Horse Chestnut + Lithium: use caution. May be possible under supervision — talk to your prescriber or pharmacist before combining. Horse chestnut's diuretic effects may reduce lithium excretion and increase serum levels.
Diuretic activity may reduce renal lithium clearance, elevating plasma concentrations.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.