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Aesculus hippocastanum
Moderate· moderate-evidence
May be possible under supervision — talk to your prescriber or pharmacist before combining.
Horse chestnut may have mild anticoagulant properties that increase bleeding risk with warfarin.
Aescin and coumarins in horse chestnut may have antiplatelet and anticoagulant activity.
Source: Natural Medicines Database · Reviewed April 2026
Horse Chestnut + Warfarin (Coumadin): use caution. May be possible under supervision — talk to your prescriber or pharmacist before combining. Horse chestnut may have mild anticoagulant properties that increase bleeding risk with warfarin.
Aescin and coumarins in horse chestnut may have antiplatelet and anticoagulant activity.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.