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Moderate· limited-evidence
May be possible under supervision — talk to your prescriber or pharmacist before combining.
Schisandra may affect warfarin metabolism and anticoagulant effectiveness.
Schisandrin may inhibit CYP3A4 and CYP2C9, affecting warfarin metabolism.
Source: Natural Medicines Database · Reviewed April 2026
Schisandra + Warfarin (Coumadin): use caution. May be possible under supervision — talk to your prescriber or pharmacist before combining. Schisandra may affect warfarin metabolism and anticoagulant effectiveness.
Schisandrin may inhibit CYP3A4 and CYP2C9, affecting warfarin metabolism.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.