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Moderate· limited-evidence
May be possible under supervision — talk to your prescriber or pharmacist before combining.
Rhodiola may have mild serotonergic and monoamine effects that could interact with antidepressants.
Rhodiola may inhibit MAO-A and MAO-B and affect serotonin transport, potentially creating additive serotonergic effects.
Source: Natural Medicines Database · Reviewed April 2026
Rhodiola + Antidepressants (SSRIs): use caution. May be possible under supervision — talk to your prescriber or pharmacist before combining. Rhodiola may have mild serotonergic and monoamine effects that could interact with antidepressants.
Rhodiola may inhibit MAO-A and MAO-B and affect serotonin transport, potentially creating additive serotonergic effects.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.