Nettle Leaf vs St. John's Wort

The aerial parts of stinging nettle used as food and medicine; leaves are highly nutritious and used for allergic rhinitis, arthritis and iron deficiency.

St. John's Wort is a flowering plant that has been used medicinally since ancient Greece. It is best known for its use in treating mild to moderate depression, where clinical evidence supports its efficacy comparable to some conventional antidepressants. It is named for its traditional harvest on St. John's Day.

quercetin, rutin, scopoletin, caffeic acid, iron, vitamin C, histamine

Hypericin, Hyperforin, Adhyperforin, Flavonoids, Xanthones

Nutritive tonic across European and Asian medicine, Allergic rhinitis (hay fever), Iron deficiency anemia, Anti-inflammatory for arthritis

Depression treatment, Wound healing, Nerve pain relief, Anti-inflammatory, Sedative

Antiallergic (hay fever research), Iron-rich nutritive, Anti-inflammatory, Antioxidant

Mild to moderate depression, Seasonal affective disorder, Anxiety, Nerve pain, Menopausal symptoms

4–6 g dried leaves as tea; 300–600 mg extract 3x daily; fresh juice 30–60 mL

300mg extract (0.3% hypericin) 3 times daily

Diuretic effects with concurrent medications, Kidney disease

Concurrent use with SSRIs or MAOIs, Bipolar disorder, Schizophrenia, Organ transplant recipients, HIV patients on antiretrovirals