St. John's Wort vs Nettle Leaf

St. John's Wort is a flowering plant that has been used medicinally since ancient Greece. It is best known for its use in treating mild to moderate depression, where clinical evidence supports its efficacy comparable to some conventional antidepressants. It is named for its traditional harvest on St. John's Day.

The aerial parts of stinging nettle used as food and medicine; leaves are highly nutritious and used for allergic rhinitis, arthritis and iron deficiency.

Hypericin, Hyperforin, Adhyperforin, Flavonoids, Xanthones

quercetin, rutin, scopoletin, caffeic acid, iron, vitamin C, histamine

Depression treatment, Wound healing, Nerve pain relief, Anti-inflammatory, Sedative

Nutritive tonic across European and Asian medicine, Allergic rhinitis (hay fever), Iron deficiency anemia, Anti-inflammatory for arthritis

Mild to moderate depression, Seasonal affective disorder, Anxiety, Nerve pain, Menopausal symptoms

Antiallergic (hay fever research), Iron-rich nutritive, Anti-inflammatory, Antioxidant

300mg extract (0.3% hypericin) 3 times daily

4–6 g dried leaves as tea; 300–600 mg extract 3x daily; fresh juice 30–60 mL

Concurrent use with SSRIs or MAOIs, Bipolar disorder, Schizophrenia, Organ transplant recipients, HIV patients on antiretrovirals

Diuretic effects with concurrent medications, Kidney disease