Agastache Rugosa Herb (Agastache rugosa): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Agastache rugosa work to relieve digestive symptoms?

Agastache rugosa contains volatile oils including methylchavicol, limonene, and beta-caryophyllene, which exert carminative and antispasmodic effects on the digestive tract. In Traditional Chinese Medicine, it is classified as an aromatic dampness-transforming herb, meaning it helps resolve stagnation and promote proper digestive function. The presence of quercetin contributes additional anti-inflammatory activity. These combined actions help relieve nausea, vomiting, and bloating associated with dampness accumulation. Evidence level: C.

Is Agastache rugosa safe to take during pregnancy?

Agastache rugosa is considered unsafe during pregnancy and is contraindicated in traditional practice, particularly at higher doses. The herb's traditional classification and effects on smooth muscle may pose risks during pregnancy. Women who are pregnant, nursing, or attempting to conceive should avoid this herb entirely. Consult a qualified healthcare provider or licensed practitioner of Traditional Chinese Medicine for appropriate alternatives for managing pregnancy-related digestive concerns.

What is the recommended dosage for Agastache rugosa?

The standard adult dosage for Agastache rugosa is 3-9 grams of dried herb prepared as a decoction, or approximately 300mg of a standardized extract taken daily. Dosage should be adjusted based on individual constitution and the specific condition being addressed. This herb should be used under the guidance of a qualified practitioner trained in Traditional Chinese Medicine or Korean medicine, as proper pattern diagnosis is essential for safe and effective use. Evidence level: C.

Does Agastache rugosa interact with any medications?

There are no well-documented drug interactions for Agastache rugosa in current clinical literature. However, due to limited research (Evidence level C), individuals taking prescription medications should exercise caution and consult a qualified healthcare provider before use. The herb's effects on cytochrome P450 enzymes and drug metabolism pathways have not been thoroughly studied, so separation from medication dosing and professional guidance is recommended.

What is Agastache rugosa used for in traditional medicine?

Agastache rugosa is used in Traditional Chinese Medicine and Korean medicine primarily for treating summer dampness syndrome, a pattern characterized by digestive disturbance, lethargy, and nausea during hot, humid weather. It serves as a carminative for relieving nausea, vomiting, and abdominal bloating. The herb also demonstrates antimicrobial properties and is traditionally used for various digestive complaints. Evidence level: C, based primarily on traditional use and preliminary research.

What side effects can Agastache rugosa cause?

Agastache rugosa may cause gastrointestinal upset in some individuals, particularly those with hot constitutions according to Traditional Chinese Medicine. The herb is contraindicated in cases of yin deficiency with heat, as it may worsen symptoms such as dry mouth, night sweats, or irritability. The volatile oil content may cause mild irritation in sensitive individuals. Discontinue use if adverse reactions occur and consult a qualified healthcare provider. Evidence level: C.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Agastache rugosa, also known as Korean mint, is a perennial aromatic plant from the Lamiaceae family native to East Asia [PMID:37631149, PMID:37949898]. It is utilized as a medicinal herb and food ingredient with reported antioxidant, anti-inflammatory, and antibacterial properties [PMID:37949898, PMID:36840144].

Contexte

Agastache rugosa is a perennial plant in the Lamiaceae family native to East Asia [PMID:37631149, PMID:37949898]. It is an aromatic plant used in the flavoring, perfume, and food industries [PMID:40915998].

Usages traditionnels

In Korea, it is used as a traditional medicine to treat gastric diseases [PMID:32916904] and its fragrance has been used for incense since the Goryeo Dynasty [PMID:36234876]. In Chinese traditional medicine, it is used to treat nausea, vomiting, and to dispel damp [PMID:28166786]. It is also used as an ingredient in salads and soups [PMID:35877308].

Composés actifs

Major active components include phenolic compounds and flavonoids, specifically rosmarinic acid, tilianin, and acacetin [PMID:38134516, PMID:35939877]. Essential oils contain monoterpenoids and phenylpropanoids, with primary chemotypes being estragole and pulegone [PMID:36234876, PMID:35463413]. Other identified compounds include apigenin, ursolic acid, protocatechuic acid, and salvianolic acid B [PMID:28166786, PMID:36766102].

Mécanisme d'action

Agastache rugosa extract (ARE) and tilianin may alleviate muscle atrophy by promoting the PI3K/Akt/FoxO3 pathway and activating mTOR [PMID:38974592]. For photoaging, ARE inactivates the MAPK/AP-1 signaling pathway and regulates TGF-β/Smad pathways to downregulate matrix metalloproteinases (MMPs) [PMID:31915640, PMID:31474086]. In bone loss, it may induce osteoblast differentiation via RUNX2 and β-catenin [PMID:33626428]. Acacetin may alleviate lung injury through the AMPK/Nrf2 pathway [PMID:39721450].

Preuves cliniques

Preuve BChemotherapy-induced nausea and vomiting (CINV)

A phase III trial found that a regimen including Huo Xiang Zheng Qi (HXZQ) oral liquid combined with 5HT3RAs and dexamethasone significantly improved the mean number of no CINV days compared to a control group [PMID:41466018].

Preuve DGastritis

In vivo mouse models showed that A. rugosa relieved mucosal damage induced by HCl/EtOH [PMID:32916904, PMID:37903549].

Preuve DPostmenopausal Osteoporosis

Water and ethanol extracts improved trabecular bone loss and suppressed loss of bone strength in ovariectomized mice [PMID:32858922, PMID:33626428].

Preuve DMemory Impairment

A. rugosa extract improved memory performance in scopolamine-induced mice by reducing hippocampal acetylcholinesterase activity and increasing choline acetyltransferase expression [PMID:39338335].

Preuve DDental Biofilm

Essential oil inhibited the growth and acid production of Streptococcus mutans and suppressed virulence factor genes [PMID:39459275].

Preuve D

Interactions médicamenteuses

Essential oil and its component estragole showed synergistic effects when combined with ketoconazole against Trichophyton species [PMID:15089034].

Synthèse des preuves

Evidence is primarily based on in vitro studies and animal models (Level D), with one Phase III clinical trial (Level B) supporting the use of a formula containing the herb for CINV. Review articles (Level C) summarize its phytochemical profile.

Sources PubMed

1.PMID: 37631149 (2023) — Agastache Species: A Comprehensive Review on Phytochemical Composition and Therapeutic Properties. · Plants (Basel, Switzerland)
2.PMID: 36234876 (2022) — Chemical Diversity of Essential Oils from Korean Native Populations of Agastache rugosa (Korean Mint). · Molecules (Basel, Switzerland)
3.PMID: 41466018 (2025) — A randomized, controlled, multicenter phase III clinical trial of Huo Xiang Zheng Qi oral liquid for the prevention and control of nausea and vomiting caused by multiday cisplatin-based regimen. · Medicine
4.PMID: 37949898 (2023) — A chromosome-level genome assembly of Korean mint (Agastache rugosa). · Scientific data
5.PMID: 38974592 (2024) — Korean Mint (Agastache rugosa) Extract and Its Bioactive Compound Tilianin Alleviate Muscle Atrophy via the PI3K/Akt/FoxO3 Pathway in C2C12 Myotubes.

Agastache Rugosa Herb

Sources et citations

Calculer une dose sûre de Agastache Rugosa Herb

Mentha Spicata Var

Fo Shou

Cardamom Seeds

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Interactions médicamenteuses

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Agastache Rugosa Herb

Sources et citations

Calculer une dose sûre de Agastache Rugosa Herb

Plantes associées

Mentha Spicata Var

Fo Shou

Cardamom Seeds

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Interactions médicamenteuses

Synthèse des preuves

Sources PubMed

Sources gouvernementales