Agrocybe aegerita (Agrocybe aegerita): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Agrocybe aegerita work for immune support?

Agrocybe aegerita exerts its effects primarily through bioactive compounds like lectin AAL and beta-glucans. These compounds act as immunomodulators, meaning they can stimulate or regulate the immune system. Specifically, lectin AAL has demonstrated the ability to bind to specific cell structures, potentially inducing apoptosis (programmed cell death) in tumor cells. The beta-glucans and polysaccharides further stimulate immune activity, such as macrophage activation. Current evidence for these mechanisms is rated Level C, derived mainly from in vitro and animal studies rather than human clinical trials.

Does Agrocybe aegerita interact with medications?

There are currently no well-documented drug interactions for Agrocybe aegerita when consumed in standard dietary amounts. However, because this mushroom demonstrates immunomodulatory properties, there is a theoretical risk that it could interfere with immunosuppressive drugs. Patients taking medications to suppress the immune system should consult a healthcare provider before using concentrated medicinal extracts. It is always recommended to inform your doctor of all herbal supplements you are taking to avoid potential contraindications.

What is the recommended dosage for Agrocybe aegerita?

The standard adult dosage for Agrocybe aegerita is 50 to 100 grams of fresh mushrooms consumed as food daily. For those using concentrated extracts, a typical dosage is 500 mg per day. These recommendations are based on traditional use and nutritional data, as clinical trials to establish standardized therapeutic dosages are lacking (Evidence Level C). Users should follow specific product label instructions and avoid exceeding recommended amounts without professional guidance.

Is Agrocybe aegerita safe during pregnancy?

Agrocybe aegerita is considered safe during pregnancy when consumed as a food in normal culinary amounts. It is a nutritious mushroom rich in protein, ergosterol, and vitamins. However, safety data regarding the use of high-dose medicinal extracts or supplements during pregnancy is insufficient. Pregnant women are advised to stick to dietary consumption and avoid concentrated extracts unless specifically approved by a qualified healthcare provider.

What are the health benefits of Agrocybe aegerita?

Agrocybe aegerita is primarily used for immune support and as a nutritive tonic. It contains unique compounds like agrocybin and lectin AAL, which have shown anti-tumor and immunomodulant activity in laboratory studies. Traditionally, it is valued for supporting general wellness and immune function. While preclinical research is promising, current evidence is rated Level C, meaning robust human clinical trials are necessary to confirm these specific health benefits.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Agrocybe aegerita, commonly known as the Pioppino mushroom, is an edible basidiomycete recognized for its nutritional value and the presence of bioactive compounds such as polysaccharides and peroxygenases [PMID:28503801, PMID:33473982].

Contexte

Agrocybe aegerita (synonym Cyclocybe aegerita) is a popular edible mushroom found in regions such as southern Italy and cultivated in Korea [PMID:28503801, PMID:23956671]. It is a saprotrophic or facultative pathogenic fungus that causes white-rot of hardwood in warm and mild climates [PMID:29334897].

Usages traditionnels

It is commonly consumed as an edible mushroom, particularly in the Campania Region of Italy [PMID:28503801].

Composés actifs

Identified compounds include polysaccharides (specifically neutral fuco-galactoglucans) [PMID:40784381], Ageritin (a ribotoxin-like protein/specific ribonuclease) [PMID:33917246], unspecific peroxygenases (AaeUPO) [PMID:37496955], aegerolysin-like proteins [PMID:25476018], and umami peptides such as DDL [PMID:38833867]. It also contains gallic acid, ascorbic acid, and various disaccharides and hexitol derivatives [PMID:28503801, PMID:37835214].

Mécanisme d'action

Ageritin inhibits protein biosynthesis by cleaving the alpha-sarcin loop of 23-28S rRNAs, leading to apoptosis [PMID:33917246]. Polysaccharides (AAP-0.2A) regulate macrophage phenotypes by increasing M1 markers (CD86, CCR7, IFN-γ) and decreasing M2 markers via NF-κB/NLRP3 and HIF1α/p53 pathways [PMID:40784381]. Recombinant Agrocybe aegerita lectin (AAL) acts as an immunoadjuvant by up-regulating genes involved in leukocyte migration, lymphocyte activation, and phagotrophy [PMID:29077528].

Preuves cliniques

Preuve DAging and Oxidative Stress

Polysaccharides (AAPS) significantly prolonged lifespan and alleviated oxidative stress in Drosophila melanogaster and D-galactose-induced aging mice by increasing antioxidant enzyme activity and regulating gut microbiota (increasing Lactobacillus) [PMID:36496591, PMID:38137185].

Preuve DColorectal Cancer (Macrophage Polarization)

Neutral fuco-galactoglucans (AAP-0.2A) influence macrophage polarization toward the M1 phenotype, affecting the proliferation and apoptosis of CT26 colorectal cancer cells [PMID:40784381].

Preuve DBacterial Virulence (P. aeruginosa PAO1)

Ethanol extracts and polysaccharide-polyphenolic complexes (AMPP) demonstrate anti-quorum sensing and antibiofilm activity, reducing swarming motility [PMID:37835214, PMID:39756726].

Sécurité et effets indésirables

Water extracts of A. aegerita have demonstrated lethal effects in mice with an LD50 of 8.77 g/kg and caused strong hepatic toxicity in BALB/c mice administered at 25 and 250 mg/kg body weight/day for 6 days [PMID:25173078].

Synthèse des preuves

The current evidence is primarily based on in vitro studies and animal models (Drosophila and mice), indicating potential antioxidant, anti-aging, and immunomodulatory properties, alongside documented toxicity in murine models.

Sources PubMed

1.PMID: 40288850 (2025) — Peroxygenase-catalysed oxyfunctionalisation reactions. · Methods in enzymology
2.PMID: 33917246 (2021) — Ageritin from Pioppino Mushroom: The Prototype of Ribotoxin-Like Proteins, a Novel Family of Specific Ribonucleases in Edible Mushrooms. · Toxins
3.PMID: 37496955 (2023) — Toward Kilogram-Scale Peroxygenase-Catalyzed Oxyfunctionalization of Cyclohexane. · Organic process research & development
4.PMID: 28503801 (2017) — Pioppino mushroom in southern Italy: an undervalued source of nutrients and bioactive compounds. · Journal of the science of food and agriculture
5.PMID: 33529432 (2021) — Chromoselective Photocatalysis Enables Stereocomplementary Biocatalytic Pathways*. · Angewandte Chemie (International ed. in English)

Agrocybe aegerita

Sources et citations

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