Allium stipitatum (Allium stipitatum): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Persian shallot work in the body?

Allium stipitatum contains bioactive sulfur compounds, particularly allicin, which are responsible for its therapeutic effects. When crushed or chopped, the enzyme alliinase converts alliin to allicin, which exhibits antimicrobial and cardiovascular properties. The herb also contains flavonoids like quercetin and isorhamnetin that provide antioxidant activity. These compounds may help relax blood vessels, reduce oxidative stress, and inhibit bacterial growth. Evidence Level: C (preliminary studies).

Can Persian shallot interact with blood thinners or medications?

Allium stipitatum may interact with anticoagulant and antiplatelet medications due to its sulfur compounds and potential blood-thinning properties. Combining it with warfarin, aspirin, or other blood thinners could increase bleeding risk. The herb may also affect blood pressure medications, potentially enhancing their effects. If you take prescription medications, especially blood thinners or antihypertensives, consult your healthcare provider before using Persian shallot therapeutically. Evidence Level: C.

What is the recommended dosage for Persian shallot?

Traditional and preliminary evidence suggests 10-30 grams of fresh Allium stipitatum daily, or approximately 500mg of standardized extract. As a food ingredient, it can be consumed liberally in cooking. For therapeutic purposes, start with lower doses and gradually increase. Standardized extracts should specify allicin or sulfur compound content. Always follow product label instructions or consult a qualified herbalist for personalized dosing. Evidence Level: C/Traditional.

Is Persian shallot safe during pregnancy and breastfeeding?

Allium stipitatum is generally considered safe during pregnancy and breastfeeding when consumed in normal food amounts. As a culinary herb used extensively in Iranian cuisine, it has a long history of safe use. However, concentrated extracts or therapeutic doses should be discussed with a healthcare provider during pregnancy. There is limited clinical research specifically on pregnant populations, so moderation is advised. Evidence Level: Traditional use.

What are the health benefits of Persian shallot?

Persian shallot (Allium stipitatum) has been used traditionally for cardiovascular health, antimicrobial support, and digestive wellness. Preliminary research suggests potential benefits for blood pressure regulation and antioxidant protection. The sulfur compounds and flavonoids may support heart health and help combat certain bacteria and fungi. In Iranian traditional medicine, it has been valued for hypertension and general wellness. Evidence Level: C (preliminary studies and traditional use).

Does Persian shallot have antimicrobial properties?

Yes, Allium stipitatum demonstrates significant antimicrobial activity in laboratory studies. The allicin and other sulfur compounds show effectiveness against various bacteria, fungi, and some parasites. This antimicrobial action explains its traditional use for digestive infections and food preservation. Research indicates activity against common pathogens, though human clinical trials are limited. Evidence Level: C (primarily in vitro studies).

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Allium stipitatum, known as Persian shallot, is a medicinal plant used in traditional Persian medicine for various ailments [PMID:33601768], demonstrating broad-spectrum antimicrobial, anti-inflammatory, and hypoglycemic properties in preclinical and clinical studies [PMID:30871159, PMID:24721027, PMID:23455213].

Contexte

Allium stipitatum (also referred to as Allium hirtifolium) is a bulbous plant native to Turkey, Iran, and Central Asia [PMID:24721027]. It is a monocotyledon plant of the lily family (Liliaceae) [PMID:25035862].

Usages traditionnels

It has been widely used in traditional Persian medicine for various ailments [PMID:33601768] and is frequently used in folk medicine for the treatment of inflammation and stress [PMID:24721027]. It is also used as a spice in Iran [PMID:23210319].

Composés actifs

Key constituents include pyridine-N-oxide alkaloids such as 2-(methyldithio)pyridine-3-carbonitrile [PMID:30871159], 2-(methyldithio)pyridine-N-oxide, 2-[(methylthiomethyl)dithio]pyridine-N-oxide, and 2,2'-dithio-bis-pyridine-N-oxide [PMID:19093848]. Other identified compounds include marasmin [PMID:21721585], shallomin [PMID:25237646], and fatty acids such as 9-hexadecenoic acid, 11,14-eicosadienoic acid, and n-hexadecanoic acid [PMID:23484141].

Mécanisme d'action

Anti-inflammatory effects are mediated through the inhibition of cyclooxygenase (COX-1 and COX-2) [PMID:24721027]. Neurological activities involve the inhibition of monoamine oxidase-A (MAO-A) and acetylcholinesterase (AChE) [PMID:24721027]. In cancer models, it induces apoptosis in HepG2 cells via up-regulation of p21, p53, puma, caspase-8, bid, bim, and bax genes, and down-regulation of the bcl-2 gene [PMID:28397098]. It may also act as a modulator of human glucokinase [PMID:37255832].

Preuves cliniques

Preuve BCold sores (Oral Herpes)

Topical 0.5% shallomin alcoholic solution cleared cold sores significantly faster than placebo, with 30% of cases clearing within six hours [PMID:25237646].

Preuve BMetabolic Syndrome (MetS)

Persian shallot extract significantly lowered serum levels of malondialdehyde and ox-LDL over three months [PMID:39957163].

Preuve DDiabetes (Animal Model)

Hydroalcoholic extract significantly decreased serum levels of fasting blood sugar (FBS) and HbA1c in a dose-dependent manner in diabetic rats [PMID:23455213].

Preuve DMRSA-infected Burn Wounds (Animal Model)

Topical hexane and dichloromethane extracts eliminated MRSA within 48-72 hours and accelerated wound contraction (95-100%) [PMID:28321262].

Preuve CVaginitis (In vitro/Review)

Allium hirtifolium exhibited anti-trichomonas activity comparable to metronidazole [PMID:22514885].

Synthèse des preuves

Evidence consists primarily of in vitro studies and animal models (D) demonstrating strong antimicrobial and metabolic effects, supported by a limited number of small-scale randomized controlled trials (B) for specific topical and metabolic applications.

Sources PubMed

1.PMID: 33601768 (2018) — Antifungal and antibiofilm activity of Persian shallot (Allium stipitatum Regel.) against clinically significant Candida spp. · Tropical biomedicine
2.PMID: 30871159 (2019) — Bioactive 2-(Methyldithio)Pyridine-3-Carbonitrile from Persian Shallot (Allium stipitatum Regel.) Exerts Broad-Spectrum Antimicrobial Activity. · Molecules (Basel, Switzerland)
3.PMID: 24721027 (2014) — Antiinflammatory and neurological activity of pyrithione and related sulfur-containing pyridine N-oxides from Persian shallot (Allium stipitatum). · Journal of ethnopharmacology
4.PMID: 28397098 (2017) — Persian shallot, Allium hirtifolium Boiss, induced apoptosis in human hepatocellular carcinoma cells. · Cytotechnology
5.PMID: 22514885 (2011) — A comprehensive review of vaginitis phytotherapy.

Allium stipitatum

Sources et citations

Calculer une dose sûre de Allium stipitatum

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Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Allium stipitatum

Sources et citations

Calculer une dose sûre de Allium stipitatum

Plantes associées

Alpinia zerumbet

Allium vineale

Bawang

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Synthèse des preuves

Sources PubMed

Sources gouvernementales