An Xa Huong (Desmodium styracifolium): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does An Xa Huong work to treat kidney stones?

An Xa Huong (Desmodium styracifolium) contains bioactive flavonoids, including isovitexin and vitexin, which exhibit lithotriptic properties that help break down calcium oxalate crystals and inhibit new stone formation. The herb also acts as a diuretic, increasing urine output to help flush existing stones from the urinary tract. Additionally, phenolic acids provide anti-inflammatory and antioxidant effects that may reduce urinary tract irritation associated with stones. Evidence level: C.

Does An Xa Huong interact with blood pressure medications?

Yes, An Xa Huong may interact with antihypertensive medications. The herb has documented hypotensive properties and can lower blood pressure. When combined with blood pressure medications or diuretics, this may cause additive effects leading to excessively low blood pressure (hypotension). Patients taking antihypertensives, diuretics, or medications affected by blood pressure changes should consult a healthcare provider before using this herb. Evidence level: C/Theoretical.

What is the recommended dosage for An Xa Huong?

The standard adult dosage for An Xa Huong is 15-30 grams of dried herb daily, typically prepared as a decoction or tea. This amount may be divided into 2-3 doses throughout the day. For concentrated extracts or standardized preparations, follow manufacturer guidelines as potency varies. Treatment duration depends on the condition being addressed. Consult a qualified herbalist for personalized dosing recommendations. Evidence level: Traditional/C.

Is An Xa Huong safe to take during pregnancy?

No, An Xa Huong is not considered safe during pregnancy. The herb possesses diuretic properties and may affect smooth muscle tone, potentially stimulating uterine contractions. There is insufficient safety data for use during breastfeeding. Pregnant and nursing women should avoid this herb entirely. Women of childbearing age should use appropriate contraception if taking An Xa Huong therapeutically. Evidence level: C/Traditional.

Can An Xa Huong help pass kidney stones naturally?

An Xa Huong has been used traditionally in Vietnamese and Chinese medicine to help pass kidney stones. Its lithotriptic compounds may assist in breaking down stones, while diuretic effects increase urine flow to facilitate passage. Preliminary research supports these traditional applications, though robust clinical trials are limited. The herb is typically used as supportive therapy alongside conventional treatment. Large stones may require medical intervention. Evidence level: C.

What are the side effects of An Xa Huong?

An Xa Huong is generally well tolerated at recommended doses. Mild gastrointestinal upset may occur in sensitive individuals. Due to its hypotensive effects, some people may experience dizziness or lightheadedness, particularly those with already low blood pressure. The herb is contraindicated in patients with hypotension. Discontinue use if allergic reactions or unusual symptoms develop. Evidence level: C/Traditional.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Desmodium styracifolium is a medicinal herb used primarily for the treatment of urolithiasis and other urinary disorders [PMID:35342799, PMID:41065914]. It exhibits antilithic, antioxidant, and anti-inflammatory properties [PMID:38317880].

Contexte

Desmodium styracifolium (Osb.) Merr., also known as Grona styracifolia, is a member of the Leguminosae family [PMID:37047046, PMID:41900416]. It is a traditional medicinal plant used in Chinese and Vietnamese medicine [PMID:38317880, PMID:34549122].

Usages traditionnels

In traditional folk and Chinese medicine, it is used to treat gallstones, gonorrhea, jaundice, cholecystitis, urolithiasis, urination disturbances, edema, and hepatitis [PMID:39454708, PMID:34458065, PMID:34549122].

Composés actifs

Primary pharmacological components include flavonoids such as schaftoside, vicenin-1, vicenin-2, vicenin-3, isovitexin, isoorientin, and isoschaftoside [PMID:35671519, PMID:31879757, PMID:30200736]. Other identified compounds include polysaccharides, triterpenoid saponins (soyasaponin I), isoflavanones, and styracifoline [PMID:38646844, PMID:2598326, PMID:17434190, PMID:34549122].

Mécanisme d'action

The herb acts through antioxidant and anti-inflammatory actions and urine alkalinization to reduce mineral encrustation in the urinary tract [PMID:38317880]. Total flavonoids (TFDS) may suppress ferroptosis via the P53/SLC7A11/GPX4 signaling pathway to relieve renal ischemia-reperfusion injury [PMID:41065914] and regulate the p38/MAPK pathway to inhibit apoptosis and autophagy in renal cells [PMID:29071538]. Polysaccharides may mitigate renal fibrosis by targeting TGF-β [PMID:40897849] and inhibit crystal adhesion while promoting crystal endocytosis [PMID:38646844]. Extracts may also alleviate cholestatic liver disease via the FXR pathway [PMID:39454708].

Preuves cliniques

Preuve DUrolithiasis (Residual stones after FURL)

Total flavonoids of Desmodium styracifolium (TFDS) were evaluated for effectiveness in removing residual stones following flexible ureteroscopic lithotripsy [PMID:39664792]

Preuve DCalcium Oxalate Urolithiasis (Animal Model)

Total flavonoids (TFDS) attenuated the formation of calcium oxalate stones in rats [PMID:28567512]. Triterpenoids reduced the incidence of stone formation from 81% to 29% in rats [PMID:8461944].

Preuve DRenal Ischemia-Reperfusion Injury (Animal Model)

Total flavonoids (TFDS) showed renoprotective properties by suppressing ferroptosis [PMID:41065914]

Synthèse des preuves

The current evidence is primarily based on in vitro studies and animal models (Level D), demonstrating significant potential for treating kidney stones and renal injury. There is limited retrospective clinical data regarding its use in post-surgical stone removal.

Sources PubMed

1.PMID: 39454708 (2025) — Desmodium styracifolium (Osb.) Merr. Extracts alleviate cholestatic liver disease by FXR pathway. · Journal of ethnopharmacology
2.PMID: 38317880 (2024) — Desmodium styracifolium: Botanical and ethnopharmacological insights, phytochemical investigations, and prospects in pharmacology and pharmacotherapy. · Heliyon
3.PMID: 38646844 (2024) — Carboxymethylated Desmodium styracifolium polysaccharide reduces the risk of calcium oxalate kidney stone formation by inhibiting crystal adhesion and promoting crystal endocytosis. · Journal of cellular physiology
4.PMID: 40897849 (2025) — Therapeutic potential of Desmodium styracifolium polysaccharide in attenuating nano-calcium oxalate induced renal injury and fibrosis. · Communications biology
5.PMID: 35342799 (2022) — The complete chloroplast genome of Desmodium styracifolium.

An Xa Huong

Sources et citations

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