Annona Senegalensis (Annona senegalensis): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Annona senegalensis work as an antimalarial?

Annona senegalensis contains bioactive compounds including acetogenins, flavonoids, and alkaloids that contribute to its therapeutic effects. Acetogenins are believed to inhibit mitochondrial complex I in parasites, potentially disrupting cellular energy production. The herb's flavonoids and tannins provide antioxidant and anti-inflammatory properties, while alkaloids may contribute to antimicrobial activity. These compounds work synergistically to support the plant's traditional uses against malaria and infections. Evidence level: C (preliminary research).

Does Annona senegalensis interact with any medications?

Limited research exists on specific drug interactions for Annona senegalensis. Due to its acetogenin content, there is theoretical concern about interactions with medications metabolized by the liver, as acetogenins may affect hepatic enzymes. The herb's potential effects on blood glucose and blood pressure could theoretically interact with antidiabetic or antihypertensive medications. Patients taking prescription medications should consult a healthcare provider before using this herb.

What is the recommended dosage for Annona senegalensis?

Traditional and preliminary evidence suggests an adult dosage of 6-15 grams of dried herb daily, typically prepared as a decoction or infusion. The herb is commonly used in divided doses throughout the day. Dosage may vary depending on the specific condition being addressed and the preparation method. Due to limited clinical studies, standardized dosing recommendations have not been established. Consult a qualified healthcare practitioner for personalized dosing guidance.

Is Annona senegalensis safe during pregnancy and breastfeeding?

Annona senegalensis is considered unsafe during pregnancy and should be avoided. The herb contains acetogenins and other compounds that may stimulate uterine contractions or potentially harm fetal development. Traditional use data and preliminary research indicate contraindication in pregnancy. Safety during breastfeeding has not been established, and use is not recommended. Women who are pregnant, planning pregnancy, or breastfeeding should not use this herb.

What is Annona senegalensis used for in traditional medicine?

Annona senegalensis has been used traditionally across sub-Saharan Africa for treating malaria, various infections, inflammatory conditions, and digestive disorders. Indigenous healers employ the leaves, roots, and bark for their antimicrobial, antiparasitic, and anti-inflammatory properties. Common applications include managing fevers, wound healing, and gastrointestinal complaints. While these uses are well-documented ethnobotanically, clinical evidence remains limited (Evidence level: C), and more rigorous research is needed.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Annona senegalensis is a multipurpose tropical shrub used in traditional medicine for various conditions, including respiratory diseases, skin diseases, and snakebites [PMID:38682320, PMID:36205572].

Contexte

Annona senegalensis Pers., also known as wild custard apple, is a shrub distributed in tropical countries, including Western and Southern Africa [PMID:38682320, PMID:37576509, PMID:36124736].

Usages traditionnels

It is used traditionally to treat respiratory and skin diseases [PMID:38682320], snakebites in Tanzania [PMID:36205572], and is used by traditional healers in South Africa for the treatment of various diseases, including cancer [PMID:39598174]. In Burkina Faso, it is cited as a plant used to increase physical performance in exercise and sport [PMID:35200754].

Composés actifs

Identified compounds include cyclosenegalin A [PMID:39162778], ent-kaurene diterpenoids [PMID:8882434], N-cerotoyltryptamine, asimicin, and ent-19-carbomethoxykauran-17-oic acid [PMID:31250675, PMID:32298749], as well as alkaloids such as (+)-catechin, (-)-anonaine, (-)-asimilobine, and (+)-nornantenine [PMID:27984920]. Other constituents include acetogenins (e.g., senegalene) [PMID:10229931, PMID:7809207] and phenolics such as quercetin-3-O-rutinoside in leaves and isorhamnetin-3-O-rutinoside in stem barks [PMID:41370287].

Mécanisme d'action

Compounds from the seeds have shown the ability to inhibit reactive oxygen species (ROS) [PMID:31250675] and nitric oxide [PMID:31250675].

Preuves cliniques

Preuve DHepatocellular carcinoma

Extract demonstrated anticancer properties in N-diethylnitrosamine-induced hepatocellular carcinoma in male Wistar rats [PMID:33152944]

Preuve DAflatoxin B1 toxicity

Methanolic leaf extract showed hepatoprotective effects against aflatoxin B1-induced toxicity in rats [PMID:38572889]

Preuve DBreast and Prostate Cancer (In vitro)

Ent-kaurenoids showed selective cytotoxicity for MCF-7 breast cancer cells and PC-3 prostate cancer cells [PMID:8882434]

Preuve DStreptococcus mutans

Alkaloids from aerial parts showed antibacterial activity, with (-)-anonaine and (+)-nornantenine showing good activity [PMID:27984920]

Preuve CLeishmaniasis

Acetogenins such as senegalene from A. senegalensis exhibit antileishmanial activity [PMID:10229931, PMID:7809207]

Preuve DEpileptic seizures

Demonstrated anti-seizure effects in Drosophila melanogaster paralytic bangsensitive mutants [PMID:33519685]

Sécurité et effets indésirables

Root extracts were found to be toxic to brine shrimps and caused chromosomal damage in rat lymphocytes [PMID:17707603].

Synthèse des preuves

The evidence is primarily based on in vitro studies, animal models (rats, Drosophila), and ethnobotanical surveys; there are no human clinical trials provided.

Sources PubMed

1.PMID: 39162778 (2024) — Total Synthesis of Cyclosenegalin A. · ChemistryOpen
2.PMID: 8882434 (1996) — Bioactive ent-kaurene diterpenoids from Annona senegalensis. · Journal of natural products
3.PMID: 38572889 (2024) — Hepatoprotective effects of leaf extract of Annona senegalensis against aflatoxin B1 toxicity in rats. · The Onderstepoort journal of veterinary research
4.PMID: 36205572 (2022) — Ethnomedicinal plants used for treatment of snakebites in Tanzania - a systematic review. · Pharmaceutical biology
5.PMID: 37576509 (2023) — Genetic and morphological diversity in populations of Annona senegalensis Pers. occurring in Western (Benin) and Southern (Mozambique) Africa. · PeerJ

Annona Senegalensis

Sources et citations

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