How does artichoke leaf extract work to improve digestion?

Artichoke leaf extract works primarily as a choleretic, stimulating the liver to increase bile production. The active compounds cynarin and chlorogenic acid enhance bile secretion, which aids in the digestion of fats and relieves dyspeptic symptoms like bloating and nausea. Additionally, these compounds offer antioxidant protection to liver cells, supporting overall hepatic function (Evidence Level B).

Does artichoke leaf extract interact with any medications?

Artichoke leaf extract has a low risk of drug interactions, but caution is advised. Because it stimulates bile flow, it may alter the absorption of certain medications. Additionally, due to its potential cholesterol-lowering effects, it may have an additive effect when combined with statins or other lipid-lowering drugs, necessitating monitoring by a healthcare provider.

What is the standard dosage for artichoke leaf extract?

The standard adult dosage for artichoke leaf extract is 320 to 640 mg of a standardized extract taken three times daily. This dosage is supported by clinical evidence for treating dyspepsia and is approved by the German Commission E. It is typically recommended to take the extract with meals to optimize digestive benefits (Evidence Level B).

Is artichoke leaf extract safe to take during pregnancy?

There is insufficient clinical data to confirm the safety of concentrated artichoke leaf extract supplements during pregnancy. While the vegetable is a common food, medicinal extracts have not been rigorously studied in pregnant populations. Consequently, most medical herbalists recommend avoiding the supplement during pregnancy and breastfeeding unless specifically prescribed by a qualified healthcare provider.

Who should not take artichoke leaf supplements?

Individuals with bile duct obstruction or existing gallstones should avoid artichoke supplements. Stimulating bile production in these conditions can cause severe pain or complications. Furthermore, those with known allergies to the Asteraceae family (such as ragweed, marigolds, or daisies) should avoid artichoke due to the potential for cross-reactive allergic reactions.

Artichaut (Cynara cardunculus var. scolymus)

Fiche d'information compilée à partir de PubMed

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Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Artichoke (Cynara cardunculus var. scolymus) is a Mediterranean plant used as both a food and a medicinal herb, recognized for its hepatoprotective and antioxidant properties [PMID:26310198, PMID:38474726].

Contexte

Cynara cardunculus var. scolymus, also known as globe artichoke, is a perennial plant of the Asteraceae family cultivated primarily in the Mediterranean, Canary Islands, Egypt, Asia, and South America [PMID:38474726, PMID:23179714]. Its edible parts include the head (capitula), flower, and leaves [PMID:38474726].

Usages traditionnels

Historically, artichoke has been used for digestive and bowel problems [PMID:26310198].

Composés actifs

Bioactive compounds include polyphenols (such as chlorogenic acid, mono-O- and di-O-caffeoylquinic acids, and cynaroside), flavonoids (luteolin and apigenin), sesquiterpene lactones (cynaropicrin), inulin, and dietary fiber [PMID:38592769, PMID:36556233, PMID:39203039, PMID:33118389].

Mécanisme d'action

Artichoke exhibits antioxidant, choleretic, and lipid-lowering effects [PMID:26310198]. Specific compounds like cynaropicrin may inhibit NF-κB activation [PMID:33982042], while other extracts demonstrate the ability to trap carbonyls and act as antiglycative agents [PMID:28873750].

Preuves cliniques

Preuve BNon-alcoholic fatty liver disease (NAFLD)

Artichoke leaf extract (600 mg daily) increased hepatic vein flow and reduced portal vein diameter compared to placebo [PMID:29520889].

Preuve AHypercholesterolaemia

While implicated in lowering cholesterol levels, the efficacy of artichoke leaf extract remains a matter of debate [PMID:19821306, PMID:12137691].

Preuve CGeneral Liver Health

Demonstrated hepatoprotective and bile-enhancing effects [PMID:26310198, PMID:23421105].

Sécurité et effets indésirables

One clinical trial reported no side effects with the use of artichoke leaf extract [PMID:29520889]; it is described as having practically no side effects [PMID:23421105].

Synthèse des preuves

Evidence is strongest for hepatoprotective effects and antioxidant potential, supported by a mix of RCTs and reviews. Evidence for treating hypercholesterolaemia is inconclusive according to systematic reviews.

Sources PubMed

1.PMID: 26310198 (2015) — Pharmacological Studies of Artichoke Leaf Extract and Their Health Benefits. · Plant foods for human nutrition (Dordrecht, Netherlands)
2.PMID: 38542782 (2024) — Functional and Therapeutic Potential of Cynara scolymus in Health Benefits. · Nutrients
3.PMID: 29520889 (2018) — Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial. · Phytotherapy research : PTR
4.PMID: 38790727 (2024) — Globe Artichoke (Cynara scolymus L.) By-Products in Food Applications: Functional and Biological Properties. · Foods (Basel, Switzerland)
5.PMID: 38474726 (2024) — An Overview of the Versatility of the Parts of the Globe Artichoke (Cynara scolymus L.), Its By-Products and Dietary Supplements.

Artichaut

Sources et citations

Turmeric (Javanese)

Milk Thistle

Artichoke Leaf Liver

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Artichaut

Sources et citations

Plantes associées

Turmeric (Javanese)

Milk Thistle

Artichoke Leaf Liver

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales