Aucklandia lappa (Aucklandia lappa): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Aucklandia lappa work for digestive problems?

Aucklandia lappa contains sesquiterpene lactones, particularly costunolide and dehydrocostus lactone, which promote gastric motility and reduce intestinal spasms through smooth muscle relaxation. These compounds exhibit carminative properties that help expel gas from the gastrointestinal tract. In Traditional Chinese Medicine, the herb moves liver and spleen qi to address stagnation patterns underlying abdominal pain and digestive discomfort. Evidence level: C (preclinical data supports mechanism; limited clinical trials available).

Does Aucklandia lappa interact with any medications?

Aucklandia lappa may interact with medications metabolized by cytochrome P450 enzymes, as its sesquiterpene lactones can modulate these pathways. Caution is advised when combining with anticoagulants, antiplatelet drugs, or medications affecting gastric motility. The herb's influence on digestive transit may alter absorption of orally administered drugs. Patients should consult healthcare providers before combining with prescription medications. Evidence level: C (theoretical interactions based on constituent properties).

What is the recommended dosage for Aucklandia lappa root?

The typical adult dosage of Aucklandia lappa is 1.5-6 grams of dried root daily, prepared as a decoction or powder. Standardized extracts are generally dosed at approximately 200mg daily. In Traditional Chinese Medicine formulations, the herb is often combined with other botanicals in smaller proportions. Dosage should be adjusted based on individual condition severity and constitution. Evidence level: C (traditional use guidelines with limited clinical standardization data).

Is Aucklandia lappa safe to take during pregnancy?

Aucklandia lappa is contraindicated during pregnancy and should be avoided. The sesquiterpene lactones present in the root, including costunolide, may stimulate uterine contractions and pose potential risks to fetal development. Traditional Chinese Medicine classifies this herb as unsafe for pregnant women. Breastfeeding women should also avoid use due to insufficient safety data. Women of reproductive age should use reliable contraception if taking this herb therapeutically. Evidence level: C (traditional contraindication supported by constituent pharmacology).

What is Aucklandia lappa used for in traditional medicine?

Aucklandia lappa, known as Mu Xiang in Traditional Chinese Medicine, is primarily used for abdominal pain, digestive stagnation, and nausea. It functions as a carminative to relieve bloating and gas while promoting healthy digestion. The herb addresses liver qi stagnation patterns characterized by distending pain and emotional irritability. It is commonly prescribed for conditions involving spleen qi deficiency with dampness accumulation. Evidence level: C (traditional use established; limited modern clinical validation).

What are the side effects of Aucklandia lappa?

Aucklandia lappa is generally well-tolerated at therapeutic doses. The most commonly reported side effects are mild gastrointestinal disturbances, including nausea, stomach discomfort, or loose stools. These effects are typically dose-dependent and resolve with reduced intake. The herb is contraindicated in individuals with yin deficiency heat or excessive fire conditions, as its warming properties may exacerbate these patterns. Evidence level: C (traditional safety profile with limited adverse event reporting).

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Aucklandia lappa (also known as Saussurea costus or Mu Xiang) is a medicinal plant native to the Himalayan region used in traditional Asian medicine for its anti-inflammatory, antimicrobial, and gastrointestinal effects [PMID:32730877, 41158126].

Contexte

Aucklandia lappa Decne. (Asteraceae) is a perennial species whose dried root or rhizome is used as a medicinal material [PMID:36117502, 41490555, 42231172]. It is synonymous with Saussurea costus and Saussurea lappa [PMID:32730877].

Usages traditionnels

In Ayurveda, Unani, Siddha, and Traditional Chinese Medicine, it is used for leukoderma, liver, kidney, and blood disorders, Qi stagnation, and tridosha [PMID:32730877]. It is traditionally used to treat asthma, rheumatism, coughs, tuberculosis [PMID:26398906, 26246732], abdominal pain, vomiting, diarrhea, and stress gastric ulcers [PMID:32183436]. Root powder is used orally with warm water for gastric problems, and root paste is applied topically for boils, blisters, leprosy, and pain relief [PMID:32730877].

Composés actifs

The core active metabolites are sesquiterpene lactones, specifically costunolide, dehydrocostus lactone, and alantolactone [PMID:41158126, 35464223, 26246732]. It also contains volatile oils, triterpenoids, phenylpropanoids, flavonoids, and low-molecular-weight polysaccharides composed of fructose and glucose [PMID:41490555, 42231172, 40476770].

Mécanisme d'action

Sesquiterpene lactones may exert biological activities via the interaction of their α-methylene-γ-butyrolactone moiety with thiol groups of biomacromolecules through Michael-addition [PMID:36117502]. Anti-inflammatory effects are mediated by suppressing the nuclear translocation of p65, degradation of IκB, and inhibition of MAPK phosphorylation [PMID:32183436]. Dehydrocostus lactone attenuates ulcerative colitis by increasing USP38 expression and decreasing histone H2B ubiquitination to suppress NF-κB-driven inflammation [PMID:40819390]. Costunolide targets HSP90 to inhibit necroptosis [PMID:41687519]. Antifungal activity against Candida albicans involves reducing chitin and (1,3)-β-D-glucan synthesis and inducing membrane permeabilization [PMID:33148941, 32347080].

Preuves cliniques

Preuve DUlcerative Colitis

Dehydrocostus lactone and sesquiterpene lactone-rich fractions reduced weight loss, macroscopic scores, and colonic pathological degeneration in DSS-induced mice models [PMID:40819390, 35623504].

Preuve DOsteoarthritis/Pain

Root extracts substantially reduced writhing in acetic acid-induced mice and reduced weight-bearing of hind limbs in MIA-induced osteoarthritis rats [PMID:33375366].

Preuve DEndometriosis

Dehydrocostus lactone induced apoptotic cell death in human endometriotic cells and decreased production of PGE2 and neurotrophins (BDNF, NGF, NT3, NT4/5) [PMID:31488032].

Preuve DCandida albicans infection

Ethanol extracts caused cell wall injury and membrane permeabilization in C. albicans with a minimal inhibitory concentration (MIC) of 0.78 mg/ml [PMID:33148941, 32347080].

Preuve DNon-small cell lung cancer (NSCLC)

Extracts combined with gefitinib enhanced efficacy in gefitinib-resistance secondary EGFR mutations in a C. elegans model [PMID:28619365].

Synthèse des preuves

The current evidence is primarily based on in vitro studies, animal models (mice, rats, C. elegans), and historical ethnopharmacological reviews. There are no human clinical trials provided in the abstracts; therefore, the overall strength of clinical evidence is low (Level D).

Sources PubMed

1.PMID: 32730877 (2020) — Aucklandia costus (Syn. Saussurea costus): Ethnopharmacology of an endangered medicinal plant of the himalayan region. · Journal of ethnopharmacology
2.PMID: 36117502 (2021) — Sesquiterpene lactones of Aucklandia lappa: Pharmacology, pharmacokinetics, toxicity, and structure-activity relationship. · Chinese herbal medicines
3.PMID: 33148941 (2020) — Aucklandia lappa Causes Membrane Permeation of Candida albicans. · Journal of microbiology and biotechnology
4.PMID: 34104740 (2021) — The complete mitochondrial genome of Aucklandia lappa Decne. (Asteraceae, Aucklandia Falc.). · Mitochondrial DNA. Part B, Resources
5.PMID: 41158126 (2025) — Aucklandia lappa Decne.: a review of its botany, cultivation, ethnopharmacology, phytochemistry, pharmacology, and practical applications.

Aucklandia lappa

Sources et citations

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