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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 29 articles PubMed · modèle : gemma4:31b
Résumé
Habbatus Sauda Oil (Nigella sativa oil) is a therapeutic herb used worldwide for its antioxidant, antimicrobial, and anti-inflammatory properties [PMID:39807848]. Its primary bioactive component is thymoquinone (TQ) [PMID:39807848, PMID:33100788].
Contexte
Nigella sativa, also known as black cumin or black seed, is a member of the Ranunculaceae family [PMID:39807848]. The oil is extracted from the seeds via methods such as cold pressing, supercritical fluid extraction, and steam distillation [PMID:36140949].
Usages traditionnels
Traditionally used in South Asian, Middle Eastern, and Mediterranean countries in foods and medicine [PMID:36978853]. It has been used to manage infectious diseases [PMID:42278598] and orally as galactogogues in India, Türkiye, and the Middle East [PMID:30000936].
Composés actifs
The oil contains thymoquinone (TQ) as a major bioactive component [PMID:39807848, PMID:33100788], as well as terpenes, beta-elemene, and essential fatty acids including linoleic, oleic, and palmitic acids [PMID:30000936, PMID:36140949].
Mécanisme d'action
Mechanisms include superoxide scavenging [PMID:36978853], inhibition of cell proliferation and induction of apoptosis by targeting epigenetic players such as UHRF1, DNMT1, and HDAC1 [PMID:35566130], and regulation of the antioxidant defense system, NF-κB signaling, caspase pathways, and TGF-β signaling [PMID:34445781].
Preuves cliniques
Preuve AType-2 Diabetes Mellitus
Nigella sativa significantly improved laboratory parameters regarding glucose and insulin profile status in humans [PMID:31817324].
Preuve CKidney Injury
Black seed oil was shown to normalize blood and urine parameters and improve disease outcomes in advanced stages [PMID:34445781].
Preuve DAllergic Rhinitis
In a rat model, Nigella sativa oil significantly lowered the frequency of nasal scratching and prevented typical inflammatory changes [PMID:36243604].
Preuve DHepatotoxicity
In male Sprague Dawley albino rats, the oil ameliorated CCl4-induced hepatotoxicity [PMID:3183399].
Preuve DBacterial Infections (E. coli O157H7)
The oil demonstrated antibacterial activity with inhibition zone diameters ranging from 9.83 to 27.48 mm depending on concentration [PMID:42091563].
Sécurité et effets indésirables
Black seed is generally well tolerated, though the oil can cause allergic contact dermatitis [PMID:30000936].
Grossesse et allaitement
Used as galactogogues in some regions, but no scientifically valid clinical trials support this use in humans; no data exist on the excretion of components into breastmilk or safety in infants [PMID:30000936].
Interactions médicamenteuses
A single dose of black seed oil in rats decreased the maximum plasma concentration (Cmax) and area under the curve (AUC0-last) of prednisolone [PMID:37978932].
Synthèse des preuves
Evidence ranges from high-level systematic reviews for diabetes (Level A) to preliminary in vitro and animal studies (Level D) for various organ-protective and antimicrobial effects.
Sources PubMed
1.PMID: 39807848 (2025) — A Comprehensive Review of the Antioxidant, Antimicrobial, and Therapeutic Efficacies of Black Cumin (Nigella sativa L.) Seed Oil and Its Thymoquinone. · Journal of medicinal food
2.PMID: 30000936 (2006) — Review: Nigella sativa (Prophetic Medicine): A Review. · Pakistan journal of pharmaceutical sciences
3.PMID: 36140949 (2022) — A Narrative Review on Various Oil Extraction Methods, Encapsulation Processes, Fatty Acid Profiles, Oxidative Stability, and Medicinal Properties of Black Seed (Nigella sativa). · Foods (Basel, Switzerland)
4.PMID: 36243604 (2022) — Effects of nigella sativa oil on allergic rhinitis: an experimental animal study. · Brazilian journal of otorhinolaryngology
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
— Effects of Nigella Sativa on Type-2 Diabetes Mellitus: A Systematic Review.
· International journal of environmental research and public health
6.PMID: 42091563 (2026) — Nigella sativa Seed Oil Antibacterial and Antibiofilm Activity against Escherichia coli O157H7 Shiga Toxin-2. · Journal of oleo science
7.PMID: 36978853 (2023) — Antioxidant Properties of Thymoquinone, Thymohydroquinone and Black Cumin (Nigella sativa L.) Seed Oil: Scavenging of Superoxide Radical Studied Using Cyclic Voltammetry, DFT and Single Crystal X-ray Diffraction. · Antioxidants (Basel, Switzerland)
8.PMID: 39517302 (2024) — Antioxidant Potential Evaluation at Various Stages of Black Cumin Oil Production. · Foods (Basel, Switzerland)
9.PMID: 34445781 (2021) — Protective Effects of Black Cumin (Nigella sativa) and Its Bioactive Constituent, Thymoquinone against Kidney Injury: An Aspect on Pharmacological Insights. · International journal of molecular sciences
10.PMID: 37621284 (2023) — Nigella sativa oil mitigates xerostomia and preserves salivary function in radiotherapy-treated mice. · Laryngoscope investigative otolaryngology
11.PMID: 39375628 (2024) — Nigella sativa oil attenuates inflammation and oxidative stress in experimental myocardial infarction. · BMC complementary medicine and therapies
12.PMID: 38534556 (2024) — Biohydrogen Production from Waste Black Cumin (Nigella Sativa) Extract Liquid. · Bioengineering (Basel, Switzerland)
13.PMID: 42278598 (2026) — Antibacterial Activity and Molecular Docking Studies of Black Cumin (Nigella sativa L.) Oil and Its Comparison with Some Antibiotics. · International journal of molecular sciences
14.PMID: 35566130 (2022) — The Potential Role of Nigella sativa Seed Oil as Epigenetic Therapy of Cancer. · Molecules (Basel, Switzerland)
15.PMID: 39494871 (2024) — Synthesis of Black Seed Oil-loaded-, Alginate-based, pH-sensitive Beads Using Electrospraying Technique. · Journal of visualized experiments : JoVE
16.PMID: 29854586 (2018) — Nigella sativa oil protects against tartrazine toxicity in male rats. · Toxicology reports
17.PMID: 26446086 (2016) — Effect of Nigella sativa oil on experimental toxoplasmosis. · Parasitology research
18.PMID: 36601514 (2022) — Thymoquinone-rich black cumin oil attenuates ibotenic acid-induced excitotoxicity through glutamate receptors in Wistar rats. · Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
19.PMID: 42238131 (2026) — Preliminary In Vitro Evaluation of the Growth-Inhibitory Effects of Nigella sativa Oil on Streptococcus mutans. · Cureus
20.PMID: 33100788 (2020) — Thymoquinone content in marketed black seed oil in Malaysia. · Journal of pharmacy & bioallied sciences
21.PMID: 39267937 (2024) — Inhibitory effect of Nigella sativa oil loaded to liposomal nanocarriers on Candida parapsilosis isolates. · Iranian journal of microbiology
22.PMID: 36145341 (2022) — Combined Ramipril and Black Seed Oil Dosage Forms Using Bioactive Self-Nanoemulsifying Drug Delivery Systems (BIO-SNEDDSs). · Pharmaceuticals (Basel, Switzerland)
23.PMID: 37978932 (2024) — In vivo assessment of black seed oil single dose on prednisolone pharmacokinetics. · The Journal of pharmacy and pharmacology
24.PMID: 39807395 (2024) — Protective effects of Nigella sativa oil, thymoquinone and dexamethasone on bleomycin-induced lung fibrosis in rats. · Veterinary research forum : an international quarterly journal
25.PMID: 38379607 (2024) — Black seed oil reverses chronic antibiotic-mediated depression and social behaviour deficits via modulation of hypothalamic mitochondrial-dependent markers and insulin expression. · IBRO neuroscience reports
26.PMID: 34540882 (2021) — A Review on Extraction, Characterization, and Applications of Bioactive Peptides From Pressed Black Cumin Seed Cake. · Frontiers in nutrition
27.PMID: 30823525 (2019) — Antioxidant and Anti-Inflammatory Properties of Nigella sativa Oil in Human Pre-Adipocytes. · Antioxidants (Basel, Switzerland)