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BC
Anti-inflammatoryVérifié
Boswellia Carteri
Boswellia carteri
Encens sacré dans les traditions islamiques et chrétiennes
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Boswellia carteri is a source of gum resin and essential oils containing boswellic acids, which exhibit anti-inflammatory, wound-healing, and anti-tumor activities [PMID:37740772, 32712132, 19296830].
Contexte
Boswellia carteri (also known as frankincense) is a tree species originating from Africa, India, and the Middle East that produces aromatic hardened gum resins [PMID:19296830, 30987305].
Usages traditionnels
Historically used for thousands of years in incense, perfumes, and traditional medicine to treat skin sores, wounds, teeth, inflammation, and urinary tract diseases [PMID:19296830, 29530608]. It has also been used in Egyptian traditional medicine [PMID:24354175] and Persian medicine for episiotomy wound healing [PMID:32971163].
Composés actifs
The primary active constituents are pentacyclic triterpene molecules known as boswellic acids (BAs), including 3-O-acetyl-11-keto-beta-boswellic acid (AKBA), alpha-boswellic acid, and beta-boswellic acid [PMID:37740772, 29720838, 16621377]. Essential oils contain volatile components such as alpha-pinene and limonene [PMID:37891886, 31582666].
Mécanisme d'action
Boswellic acids exhibit anti-inflammatory effects through the inhibition of cyclooxygenase (COX-1 and COX-2) enzymes [PMID:24354175]. They may suppress T cell function by affecting IL-2 transcription factor activity and reducing the secretion of IL-2 and IFN-gamma [PMID:32712132]. In cancer cells, they may induce apoptosis via caspase activation, upregulation of Bax expression, and cell cycle arrest at the G2/M or G1 phase [PMID:37740772, 29970196, 12600419].
Preuves cliniques
Preuve BSecond-degree burn wounds
A sterilized formulation of B. carteri (40%) was compared to silver sulfadiazine cream 1% for healing efficacy [PMID:36895452].
Preuve BEpisiotomy wounds
Frankincense extract sitz-baths were investigated for their efficacy and safety in improving the wound healing process in primiparous women [PMID:32971163].
Sécurité et effets indésirables
One review describes natural compounds like boswellic acids as being devoid of major toxicities [PMID:31443458].
Interactions médicamenteuses
Extracts of B. carteri gum-resin have been identified as potent, non-selective inhibitors of major drug-metabolizing cytochrome P450 enzymes, including CYP1A2, 2C8, 2C9, 2C19, 2D6, and 3A4 [PMID:16364338].
Synthèse des preuves
Evidence consists primarily of in vitro studies, animal models, and a few small-scale randomized clinical trials focusing on wound healing and anti-inflammatory properties.
Sources PubMed
1.PMID: 37740772 (2024) — The journey of boswellic acids from synthesis to pharmacological activities. · Naunyn-Schmiedeberg's archives of pharmacology
2.PMID: 36015437 (2022) — Comparison of Volatile Constituents Present in Commercial and Lab-Distilled Frankincense (Boswellia carteri) Essential Oils for Authentication. · Plants (Basel, Switzerland)
3.PMID: 32712132 (2020) — Boswellia carteri extract and 3-O-acetyl-alpha-boswellic acid suppress T cell function. · Fitoterapia
4.PMID: 19296830 (2009) — Frankincense oil derived from Boswellia carteri induces tumor cell specific cytotoxicity. · BMC complementary and alternative medicine
5.PMID: 31443458 (2019) — An Update on Pharmacological Potential of Boswellic Acids against Chronic Diseases.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 36895452 (2023) — Burn Wound Healing Effect of a Sterilized Traditional Formulation of Boswellia carteri vs. Silver Sulfadiazine Cream 1% in Patients Presenting Second-degree Burn Wounds: A Randomized, Double-blind Clinical Trial. · Iranian journal of medical sciences
7.PMID: 29720838 (2018) — Optimal Processing Conditions of Boswellia carteri Birdw. Using Response Surface Methodology. · Pharmacognosy magazine
8.PMID: 37891886 (2023) — Boswellia Essential Oil: Natural Antioxidant as an Effective Antimicrobial and Anti-Inflammatory Agent. · Antioxidants (Basel, Switzerland)
9.PMID: 25637505 (2015) — Scientific evaluation of medicinal plants used for the treatment of abnormal uterine bleeding by Avicenna. · Archives of gynecology and obstetrics
10.PMID: 31582666 (2019) — The Effects of Frankincense Essential Oil on Stress in Rats. · Journal of oleo science
11.PMID: 30987305 (2019) — Organic Certification is Not Enough: The Case of the Methoxydecane Frankincense. · Plants (Basel, Switzerland)
12.PMID: 36565160 (2022) — Synergistic Effect of HAD-B1 and Afatinib Against Gefitinib Resistance of Non-Small Cell Lung Cancer. · Integrative cancer therapies
13.PMID: 32971163 (2021) — Episiotomy wound healing by Commiphora myrrha (Nees) Engl. and Boswellia carteri Birdw. in primiparous women: A randomized controlled trial. · Journal of ethnopharmacology
14.PMID: 40352903 (2025) — Boswellia carteri Birdw. Resin Extract Induces Phase-I Cytochrome P-450 Enzyme Gene Expressions in Human Hepatocarcinoma (Hep G2) Cells: In vitro and in silico Studies. · Biologics : targets & therapy
15.PMID: 33342418 (2021) — Phyto-Facilitated Bimetallic ZnFe2O4 Nanoparticles via Boswellia carteri: Synthesis, Characterization, and Anti-Cancer Activity. · Anti-cancer agents in medicinal chemistry
16.PMID: 33880765 (2021) — In vitro anti-inflammatory and antioxidant activities of ZnFe2 O4 and CrFe2 O4 nanoparticles synthesized using Boswellia carteri resin. · Journal of food biochemistry
17.PMID: 16364338 (2006) — Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction. · Journal of chromatography. A
18.PMID: 29696822 (2018) — Chemical Variation in Essential Oils from the Oleo-gum Resin of Boswellia carteri: A Preliminary Investigation. · Chemistry & biodiversity
19.PMID: 24856757 (2014) — Cardioprotective and antioxidant effects of oleogum resin "Olibanum" from Bos Boswellia carteri Birdw. (Bursearceae). · Chinese journal of natural medicines
20.PMID: 32119592 (2020) — Evaluation of mucoadhesive property and the effect of Boswellia carteri gum on intranasal vaccination against small ruminant morbillivirus infection (PPR). · Journal of immunoassay & immunochemistry
21.PMID: 25468535 (2015) — Identification of odorants in frankincense (Boswellia sacra Flueck.) by aroma extract dilution analysis and two-dimensional gas chromatography-mass spectrometry/olfactometry. · Phytochemistry
22.PMID: 29530608 (2018) — Frankincense and myrrh essential oils and burn incense fume against micro-inhabitants of sacral ambients. Wisdom of the ancients? · Journal of ethnopharmacology
23.PMID: 16621377 (2006) — Anti-inflammatory activities of the triterpene acids from the resin of Boswellia carteri. · Journal of ethnopharmacology
24.PMID: 15922374 (2005) — A chemical investigation by headspace SPME and GC-MS of volatile and semi-volatile terpenes in various olibanum samples. · Phytochemistry
25.PMID: 32082975 (2020) — 3-O-Acetyl-11-keto- β -boswellic acid ameliorated aberrant metabolic landscape and inhibited autophagy in glioblastoma. · Acta pharmaceutica Sinica. B
26.PMID: 25795279 (2015) — Effects of the Four-Herb Compound ANBP on Wound Healing Promotion in Diabetic Mice. · The international journal of lower extremity wounds
27.PMID: 29970196 (2018) — 3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase. · Journal of experimental & clinical cancer research : CR
28.PMID: 12600419 (2003) — Boswellic acid acetate induces differentiation and apoptosis in highly metastatic melanoma and fibrosarcoma cells. · Cancer detection and prevention
29.PMID: 24354175 (2013) — Major constituents of Boswellia carteri resin exhibit cyclooxygenase enzyme inhibition and antiproliferative activity. · Natural product communications