Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Caesalpinia bonduc (Caesalpinia bonduc) est connu en anglais sous les noms Nicker Bean, Gray Nicker, Bonduc. Il est traditionnellement utilisé pour paludisme, diabète, fièvre.
Caesalpinia bonduc est-il sûr pendant la grossesse ?
Caesalpinia bonduc n'est pas recommandé pendant la grossesse. Consultez votre professionnel de santé pour des alternatives.
Caesalpinia bonduc interagit-il avec les médicaments ?
Caesalpinia bonduc ne présente pas d'interaction médicamenteuse majeure bien documentée dans notre base, mais informez toujours votre professionnel de santé de tous les compléments que vous prenez.
Quels sont les effets secondaires de Caesalpinia bonduc ?
Dosage should not exceed 3g of seed kernel powder twice daily due to risk of alkaloid toxicity.. Contraindicated in pregnancy and lactation due to potential abortifacient and toxic effects.. Large doses may cause GI upset, vomiting, and neurological symptoms.. Use with caution in patients with liver or kidney impairment.
Comment calculer une dose sûre de Caesalpinia bonduc ?
Utilisez le calculateur de posologie gratuit d'HerbAlly — saisissez la dose adulte de référence pour Caesalpinia bonduc, plus l'âge et le poids, pour obtenir une estimation pédiatrique selon Clark / Young. Ne dépassez jamais la dose adulte.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Caesalpinia bonduc, also known as bonduc nut or fever nut, is a medicinal plant used in various traditional systems for treating conditions such as diabetes, inflammation, and fever [PMID:34192600, PMID:37987793].
Contexte
Caesalpinia bonduc (L.) Roxb., belonging to the Fabaceae family, is a plant with a pantropical distribution commonly found in evergreen and moist deciduous forests [PMID:34192600, PMID:37987793].
Usages traditionnels
The plant is used in Ayurveda, Siddha, and homeopathy to treat fever, inflammation, diabetes, cardiovascular disorders, cancer, birth control, and tumors [PMID:34192600, PMID:37987793, PMID:19429358]. In India, seeds are used to regulate menstrual disorders in PCOS [PMID:34192600], while in Benin, roots are used for urinary tract infections, pain, diabetes, reproductive disorders, and as an aphrodisiac [PMID:42256646, PMID:33574881]. It has also been used by Siddha healers for psoriasis [PMID:20920562] and traditionally to treat snake bites [PMID:15070178].
Composés actifs
The plant contains over 97 phytochemicals [PMID:37987793]. Key compounds include cassane-type diterpenoids (e.g., caesalpinolides, neocaesalpins) [PMID:34184408, PMID:32985266, PMID:24447681, PMID:24990509, PMID:19155029], cassane-type alkaloids (caesalminines C-G) [PMID:38280683], flavonoids [PMID:34400957], phenolics [PMID:32256963], and a water-soluble gluco-arabinan polysaccharide [PMID:23218357]. Seeds also contain a serine proteinase inhibitor (CbTI) [PMID:17400464].
Mécanisme d'action
In diabetic rat models, polyphenol extracts may attenuate hyperglycemia by upregulating insulin secretion and inhibiting the JNK signaling pathway, affecting genes such as Pdx-1, Ins-1, ngn-3, GLUT-4, and IRS-1 [PMID:32256963]. Ethanolic seed extracts trigger a yeast metacaspase-dependent apoptotic pathway in Candida albicans via mitochondrial dysfunction and enhanced production of calcium and reactive oxygen species (ROS) [PMID:36093184]. Certain compounds have shown inhibitory effects on type-4 phosphodiesterase (PDE4) and nuclear factor-kappa B (NF-κB) expression [PMID:31962203].
Preuves cliniques
Preuve DDiabetes Mellitus
Aqueous-methanol seed kernel extract, alone or synergistically with Gymnema sylvestre, improved fasting blood glucose, insulin, HbA1c, and oxidative stress markers (SOD and CAT) in alloxan-induced diabetic rats [PMID:40354793]. Polyphenol extracts restored blood glucose, insulin, and glycosylated hemoglobin in diabetic rats [PMID:32256963].
Preuve DBenign Prostatic Hyperplasia (BPH)
Seed extracts significantly decreased testosterone propionate-induced BPH in male Wistar rats [PMID:35651598].
Preuve DPsoriasis
Hydroalcoholic extract fractions (butanol and water) produced significant orthokeratosis and reduced relative epidermal thickness in mouse tail tests [PMID:20920562].
Preuve DInflammation and Pain
Seed coat extract decreased induced inflammation in Carrageenan and Egg albumin-induced paw edema models in rats and showed antinociceptive activity [PMID:23057003].
Preuve DCandidiasis
Ethanolic extract of seeds demonstrated in-vitro anticandidal activity against Candida albicans [PMID:36093184].
Preuve D
Sécurité et effets indésirables
A 90-day oral toxicity study of ethanolic root extract in rats (up to 500 mg/kg/day) showed no deaths, abnormal clinical signs, or significant changes in body weight and organ weights [PMID:33574881]. However, acute oral administration of leaf and young twig extracts (2000-5000 mg/kg) caused significant alterations in biomarkers and cellular damage to the liver [PMID:24311878]. In sub-acute studies, doses of 400 mg/kg and above of leaf/twig extracts caused significant biomarker changes [PMID:24311878].
Synthèse des preuves
The current evidence is primarily based on in-vitro studies and animal models (Level D), with some systematic reviews of traditional use and phytochemistry (Level A/C). There are no human clinical trials provided in the abstracts.
Sources PubMed
1.PMID: 33143632 (2021) — Herbal Medicines for Diabetes Management and its Secondary Complications. · Current diabetes reviews
2.PMID: 37987793 (2024) — Botany, traditional usages, phytochemistry, pharmacology, and toxicology of Guilandina bonduc L.: a systematic review. · Naunyn-Schmiedeberg's archives of pharmacology
3.PMID: 34192600 (2021) — Caesalpinia bonduc (L.) Roxb. as a promising source of pharmacological compounds to treat Poly Cystic Ovary Syndrome (PCOS): A review. · Journal of ethnopharmacology
4.PMID: 36093184 (2022) — Ethanolic extract of Caesalpinia bonduc seeds triggers yeast metacaspase-dependent apoptotic pathway mediated by mitochondrial dysfunction through enhanced production of calcium and reactive oxygen species (ROS) in Candida albicans. · Frontiers in cellular and infection microbiology
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
Ethanolic root extract increased mount frequency in male Wistar rats [PMID:33891329].
Preuve DStress/Adaptogenic
Seed coat and kernel extracts increased swim endurance time and overcame stress-induced hypoglycemia and hyperlipidemia in rats [PMID:16815659].
— Synergistic Antioxidant and Antidiabetic Effects of Caesalpinia bonduc (L.) and Gymnema sylvestre (Retz.) in Alloxan-Induced Diabetic Rats.
· Chemistry & biodiversity
6.PMID: 32985266 (2021) — Antifeedant and ovicidal activities of a new cassane and other compounds from Caesalpinia welwitschiana Oliv. and Caesalpinia bonduc L. against Tuta absoluta (Lepidoptera: Gelechiidae). · Natural product research
7.PMID: 20920562 (2011) — Screening of Caesalpinia bonduc leaves for antipsoriatic activity. · Journal of ethnopharmacology
8.PMID: 34184408 (2021) — Cassane-Type Diterpenoids from the Seeds of Caesalpinia bonduc (L.) Roxb. · Chemistry & biodiversity
9.PMID: 23057003 (2012) — Evaluation of Caesalpinia bonduc seed coat extract for anti-inflammatory and analgesic activity. · Journal of advanced pharmaceutical technology & research
10.PMID: 35651598 (2022) — Administration of Caesalpinia bonduc Seed Extracts Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia (BPH) in Male Wistar Rats. · Research and reports in urology
11.PMID: 32256963 (2020) — Effect of Caesalpinia bonduc Polyphenol Extract on Alloxan-Induced Diabetic Rats in Attenuating Hyperglycemia by Upregulating Insulin Secretion and Inhibiting JNK Signaling Pathway. · Oxidative medicine and cellular longevity
12.PMID: 33891329 (2021) — A comparative study of Caesalpinia bonduc (L.) Roxb. root extracts on sexual behaviour in male Wistar rats. · Andrologia
13.PMID: 19429358 (2009) — In vitro and in vivo antimicrobial activities of seeds of Caesalpinia bonduc (Lin.) Roxb. · Journal of ethnopharmacology
14.PMID: 15070178 (2004) — Leaf extract of Caesalpinia bonduc Roxb. (Caesalpiniaceae) induces an increase of contractile force in rat skeletal muscle in situ. · Phytomedicine : international journal of phytotherapy and phytopharmacology
15.PMID: 33730614 (2021) — Chemical composition, biological properties and bioinformatics analysis of two Caesalpina species: A new light in the road from nature to pharmacy shelf. · Journal of pharmaceutical and biomedical analysis
16.PMID: 24447681 (2014) — Cassane-type diterpenoids from the seed kernels of Caesalpinia bonduc. · Fitoterapia
17.PMID: 42256646 (2026) — Phytochemical Profile and Biological Activities of the Roots of Caesalpinia bonduc and the Aerial Part of Heliotropium indicum. · Biochemistry research international
18.PMID: 38280683 (2024) — New cassane-type alkaloids and diterpenoids from the pericarps of Caesalpinia bonduc. · Fitoterapia
19.PMID: 40003768 (2025) — Botanical Antifeedants: An Alternative Approach to Pest Control. · Insects
20.PMID: 33574881 (2021) — A 90-Day Oral Toxicity Study of an Ethanolic Root Extract of Caesalpinia bonduc (L.) Roxb. in Wistar Rats. · Evidence-based complementary and alternative medicine : eCAM
21.PMID: 24990509 (2014) — New cassane-type diterpenoids from Caesalpinia bonduc. · Chemical & pharmaceutical bulletin
22.PMID: 34400957 (2021) — Bioassay-guided Isolation of Flavonoids from Caesalpinia bonduc (L.) Roxb. and Evaluation of Their Cytotoxicity. · Iranian journal of pharmaceutical research : IJPR
23.PMID: 24311878 (2013) — Evaluation of the toxicological profile of the leaves and young twigs of Caesalpinia bonduc (Linn) roxb. · African journal of traditional, complementary, and alternative medicines : AJTCAM
24.PMID: 33358853 (2021) — Pharmacological reflection of plants traditionally used to manage diabetes mellitus in Tanzania. · Journal of ethnopharmacology
25.PMID: 17400464 (2007) — A trypsin and chymotrypsin inhibitor from Caesalpinia bonduc seeds: isolation, partial characterization and insecticidal properties. · Plant physiology and biochemistry : PPB
27.PMID: 16815659 (2006) — Adaptogenic activity of Caesalpinia bonduc seed extracts in rats. · Journal of ethnopharmacology
28.PMID: 19413105 (2009) — Minor chemical constituents of Caesalpinia bonduc. · Natural product communications
29.PMID: 31962203 (2020) — New cassane-type diterpenoids from kernels of Caesalpinia bonduc (Linn.) Roxb. and their inhibitory activities on phosphodiesterase (PDE) and nuclear factor-kappa B (NF-κB) expression. · Bioorganic chemistry
30.PMID: 23218357 (2013) — Structural studies of an immunostimulating gluco-arabinan from seeds of Caesalpinia bonduc. · Carbohydrate polymers