What is Castanea sativa (Castanea sativa) used for?

Castanea sativa (Castanea sativa) is traditionally used for coqueluche, affections respiratoires, aliment nutritif. Always consult a healthcare professional before use.

Is Castanea sativa safe during pregnancy?

Castanea sativa is not recommended during pregnancy. Consult your healthcare provider for alternatives.

Does Castanea sativa interact with medications?

Castanea sativa has no well-documented major drug interactions in our database, but always inform your healthcare provider about all supplements you take.

What are the side effects of Castanea sativa?

Avoid use during pregnancy due to potential teratogenic or abortifacient risk.. Avoid use while breastfeeding; insufficient safety data in lactating women.. Contraindicated in Rare chestnut allergy.. Contraindicated in Pregnancy caution.. May cause: Constipation with excess tannins.. Standard adult dosage: 2-4g dried leaves as tea; nuts as food.

Castanea sativa (Castanea sativa)

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Castanea sativa (sweet chestnut) is a European tree species valued for its nutritional fruits and wood, containing bioactive compounds with antioxidant and health-promoting properties [PMID:36553794, PMID:25204784].

Contexte

Castanea sativa Mill. is a species of the Fagaceae family abundant in South Europe and Asia [PMID:25204784]. It is an economically important species primarily used for fruit and wood production [PMID:36553794, PMID:38909221].

Usages traditionnels

The plant has been traditionally employed in nutrition and for the treatment of various gastrointestinal and respiratory infections [PMID:37896225].

Composés actifs

Active compounds include phenolics, flavonoids, tannins (specifically hydrolysable tannins in wood), vitamin E, lignin, oligosaccharides, and triterpenoid saponins such as chestnoside A and B [PMID:36615589, PMID:34053557, PMID:28363853, PMID:36360132].

Mécanisme d'action

Chestnut extracts may act by quenching reactive oxygen species (ROS) [PMID:26448818], reducing intracellular ROS formation in cardiomyocytes [PMID:23533692], and interfering with inflammation targets such as nuclear factor κB (NF-κB) [PMID:39203029].

Preuves cliniques

Preuve CSkin Aging/UV Protection

Phyto-extracts of C. sativa in cream formulations may serve as cosmeceuticals to protect skin against the injurious effects of UV radiation [PMID:26448818]

Preuve DAbdominal Adiposity

Dietary supplementation at 1.1% in FVB/n mice reduced abdominal adipose tissue and lowered serum cholesterol [PMID:32260459]

Preuve DCardiovascular Protection

Bark extract reduced ROS formation and improved cell viability in neonatal rat cardiomyocytes; it also induced transient negative chronotropic and positive inotropic effects in guinea pig atria [PMID:23533692]

Preuve DCancer/Mutagenicity

Bark extract demonstrated antimutagenic properties against mitomycin C and vinblastine in TK6 cells, and heartwood triterpenoids showed cytotoxicity against breast (MCF-7) and prostate (PC3) cancer cell lines [PMID:37896225, PMID:28363853]

Sécurité et effets indésirables

Bark extract was found to be virtually nontoxic in the In Vitro Mammalian Cell Micronucleus Test [PMID:37896225].

Synthèse des preuves

The current evidence is primarily based on in vitro studies, animal models, and literature reviews (Levels C and D), focusing on antioxidant, anti-inflammatory, and cardioprotective properties. There are no human clinical trials provided in the source abstracts.

Sources PubMed

1.PMID: 26448818 (2015) — Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity. · Oxidative medicine and cellular longevity
2.PMID: 36553794 (2022) — Sweet Chestnut (Castanea sativa Mill.) Nutritional and Phenolic Composition Interactions with Chestnut Flavor Physiology. · Foods (Basel, Switzerland)
3.PMID: 25204784 (2015) — Castanea sativa by-products: a review on added value and sustainable application. · Natural product research
4.PMID: 36615589 (2023) — Tannins-Based Extracts: Effects on Gut Chicken Spontaneous Contractility. · Molecules (Basel, Switzerland)
5.PMID: 28363853 (2017) — Cytotoxic triterpenoids isolated from sweet chestnut heartwood (Castanea sativa) and their health benefits implication.

Castanea sativa

Sources et citations

Lentibularia vulgaris

Illicium verum

Escallonia Resinosa

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Castanea sativa

Sources et citations

Plantes associées

Lentibularia vulgaris

Illicium verum

Escallonia Resinosa

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales