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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Inonotus obliquus, known as Chaga, is a medicinal mushroom used since the sixteenth century for various therapeutic purposes [PMID:38813471]. Modern research indicates it possesses antioxidant, anti-inflammatory, anticancer, and anti-diabetic properties [PMID:38813471, PMID:38116085, PMID:39170453].
Contexte
Chaga (Inonotus obliquus) is a parasitic fungus that grows on birch trees [PMID:29484963]. It is characterized as a medicinal mushroom and functional food with high nutritional value [PMID:37513265, PMID:19407959].
Usages traditionnels
Traditional applications include the treatment of gastrointestinal cancer, diabetes, bacterial infections, liver diseases [PMID:38813471], breast, cervix, and skin cancers [PMID:38116085], gastritis, gastric ulcers, and tuberculosis of the bones [PMID:23149251, PMID:32877719]. It has also been used in pipe smoking rituals and mystical future forecasts [PMID:38116085].
Composés actifs
Bioactive compounds include polysaccharides (specifically Inonotus obliquus polysaccharide or IOPS) [PMID:33947037], triterpenoids (such as inotodiol, betulin, lanosterol, ergosterol, and $\beta$-sitosterol) [PMID:35335249, PMID:40243601], polyphenols, flavonoids, steroids, and lignin metabolites [PMID:38813471, PMID:38116085, PMID:39202879].
Mécanisme d'action
Mechanisms include the suppression of iNOS and NO production via lanostanoids [PMID:33434790], regulation of the NOS-cGMP-PDE5 signaling pathway for glucolipid metabolism [PMID:39059831], and induction of autophagy via the AMPK-mTOR pathway in breast cancer cells [PMID:33798660]. It may also act by inhibiting energy metabolism (glycolysis and mitochondrial respiration) and suppressing STAT3 activity in oral cancer cells [PMID:38720012], and regulating Nrf2 signaling to exert antioxidative effects [PMID:30878614].
Preuves cliniques
Preuve DBladder Cancer (Dog Organoids)
Chaga extract inhibited cell viability in a concentration-dependent manner, arrested the cell cycle, and induced apoptosis [PMID:37153767].
Preuve DBreast Cancer (Mice/In Vitro)
Oral administration of Chaga mushroom extract (2 g/kg) demonstrated anti-tumor effects in 4T1 tumor-bearing BALB/c mice [PMID:33798660].
Preuve DOral Cancer (In Vitro)
Extract reduced cell viability and proliferation of HSC-4 cells by inhibiting glycolysis and mitochondrial membrane potential [PMID:38720012].
Preuve DRenal Fibrosis (Mice)
Chaga ameliorates folic acid-induced renal fibrosis in mice [PMID:40160460].
Preuve DType 2 Diabetes (Rats)
Chaga extracts (50 and 100 mg/kg) were used to treat glucolipid metabolism disorders and abnormal renal functions in HFD/STZ-induced T2DM rats [PMID:39059831].
Preuve DAtopic Dermatitis (Mice)
Sécurité et effets indésirables
A case report identified oxalate nephropathy (diffuse tubular atrophy and interstitial fibrosis) in a patient ingesting 4-5 teaspoons of Chaga mushroom powder daily, noting that Chaga contains extremely high oxalate concentrations [PMID:23149251]. Additionally, wild chaga conks have been found to contain high activity concentrations of 40K and mild contamination with 137Cs [PMID:37089251].
Synthèse des preuves
The current evidence is primarily based on in vitro studies, animal models (mice/rats), and a single case report. There is a lack of human clinical trials (RCTs) or systematic reviews of clinical data, placing the overall strength of clinical evidence at level D.
Sources PubMed
1.PMID: 38813471 (2024) — Therapeutic properties of Inonotus obliquus (Chaga mushroom): A review. · Mycology
2.PMID: 38116085 (2023) — Chaga mushroom: a super-fungus with countless facets and untapped potential. · Frontiers in pharmacology
3.PMID: 37513265 (2023) — Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production-A Review. · Molecules (Basel, Switzerland)
4.PMID: 35335249 (2022) — Supercritical CO2 Extraction of Triterpenoids from Chaga Sterile Conk of Inonotus obliquus. · Molecules (Basel, Switzerland)
5.PMID: 37153767 (2023) — Anti-cancer activity of Chaga mushroom (Inonotus obliquus) against dog bladder cancer organoids.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
7.PMID: 40160460 (2025) — Inonotus obliquus (chaga) ameliorates folic acid-induced renal fibrosis in mice: the crosstalk analysis among PT cells, macrophages and T cells based on single-cell sequencing. · Frontiers in pharmacology
8.PMID: 39170453 (2024) — A brief overview of the medicinal and nutraceutical importance of Inonotus obliquus (chaga) mushrooms. · Heliyon
12.PMID: 34195023 (2021) — Inonotus obliquus - from folk medicine to clinical use. · Journal of traditional and complementary medicine
13.PMID: 33639077 (2021) — Medicinal Mushrooms against Influenza Viruses. · International journal of medicinal mushrooms
14.PMID: 33800424 (2021) — Comparison of Polysaccharides Extracted from Cultivated Mycelium of Inonotus obliquus with Polysaccharide Fractions Obtained from Sterile Conk (Chaga) and Birch Heart Rot. · Journal of fungi (Basel, Switzerland)
15.PMID: 39059831 (2024) — Inonotus obliquus (Chaga) against HFD/STZ-induced glucolipid metabolism disorders and abnormal renal functions by regulating NOS-cGMP-PDE5 signaling pathway. · Chinese journal of natural medicines
16.PMID: 40868987 (2025) — Molecular Mechanisms of Phytochemicals from Chaga Mushroom (Inonotus obliquus) Against Colorectal Cancer: Insights from Network Pharmacology, Molecular Docking, and Bioinformatics. · International journal of molecular sciences
17.PMID: 19407959 (2009) — Progress of research on Inonotus obliquus. · Chinese journal of integrative medicine
19.PMID: 39202879 (2024) — Impact of Incorporating Dried Chaga Mushroom (Inonotus obliquus) into Gluten-Free Bread on Its Antioxidant and Sensory Characteristics. · Molecules (Basel, Switzerland)
20.PMID: 38720012 (2024) — Chaga mushroom extract suppresses oral cancer cell growth via inhibition of energy metabolism. · Scientific reports
22.PMID: 38046279 (2023) — Chaga mushroom triterpenoids as adjuncts to minimally invasive cancer therapies: A review. · Current research in toxicology
23.PMID: 32877719 (2021) — Deciphering the antitumoral potential of the bioactive metabolites from medicinal mushroom Inonotus obliquus. · Journal of ethnopharmacology
24.PMID: 40508014 (2025) — Elucidating the Anti-Diabetic Mechanisms of Mushroom Chaga (Inonotus obliquus) by Integrating LC-MS, Network Pharmacology, Molecular Docking, and Bioinformatics. · International journal of molecular sciences
25.PMID: 33798660 (2021) — Chaga mushroom extract induces autophagy via the AMPK-mTOR signaling pathway in breast cancer cells. · Journal of ethnopharmacology
26.PMID: 40243601 (2025) — Comparative Study of Chaga (Inonotus obliquus) Dietary Supplements Using Complementary Analytical Techniques. · International journal of molecular sciences
27.PMID: 41581894 (2026) — Chaga Mushroom (Inonotus obliquus) Attenuates DNCB-Induced Atopic Dermatitis by Modulating Oxidative Stress and Cytokine Expression. · Journal of microbiology and biotechnology
28.PMID: 30878614 (2019) — Inonotus obliquus polysaccharides protect against Alzheimer's disease by regulating Nrf2 signaling and exerting antioxidative and antiapoptotic effects. · International journal of biological macromolecules
29.PMID: 27562990 (2016) — [Composition and biological activity of triterpenes and steroids from Inonotus obliquus (chaga)]. · Biomeditsinskaia khimiia
30.PMID: 29484963 (2018) — Chaga ( Inonotus obliquus), a Future Potential Medicinal Fungus in Oncology? A Chemical Study and a Comparison of the Cytotoxicity Against Human Lung Adenocarcinoma Cells (A549) and Human Bronchial Epithelial Cells (BEAS-2B). · Integrative cancer therapies