Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Combretum Molle (Combretum molle) est connu en anglais sous les noms Velvet Bushwillow, Velvet Combretum, Umdubu. Il est traditionnellement utilisé pour traitement de la schistosomiase, cicatrisation des plaies, infections bactériennes.
Combretum Molle est-il sûr pendant la grossesse ?
Combretum Molle n'est pas recommandé pendant la grossesse. Consultez votre professionnel de santé pour des alternatives.
Combretum Molle interagit-il avec les médicaments ?
Combretum Molle ne présente pas d'interaction médicamenteuse majeure bien documentée dans notre base, mais informez toujours votre professionnel de santé de tous les compléments que vous prenez.
Quels sont les effets secondaires de Combretum Molle ?
Pregnancy: Unsafe due to potential uterine stimulant effects and lack of safety data.. Nursing: Unsafe; avoid during breastfeeding due to possible excretion of active compounds.. Side effects: Mild digestive upset (nausea, diarrhea) may occur; rare allergic reactions (rash, itching) have been reported.. Contraindicated in pregnancy; use with caution in individuals with gastrointestinal disorders due to tannin content.
Comment calculer une dose sûre de Combretum Molle ?
Utilisez le calculateur de posologie gratuit d'HerbAlly — saisissez la dose adulte de référence pour Combretum Molle, plus l'âge et le poids, pour obtenir une estimation pédiatrique selon Clark / Young. Ne dépassez jamais la dose adulte.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Combretum molle is a deciduous shrub from tropical Africa used in traditional medicine for various ailments, including malaria and bacterial infections [PMID:32248808, PMID:11801378].
Contexte
Combretum molle (Combretaceae) is a graceful deciduous shrub distributed primarily in tropical Africa [PMID:32248808]. It is utilized in African traditional medicine to treat a variety of diseases [PMID:37111925].
Usages traditionnels
Traditional uses include the treatment of malaria, diabetes, bacterial, liver, and cardiovascular diseases [PMID:32248808]. It is also used for pneumonia, venereal diseases (such as syphilis), mental problems, sore throats, colds, fever, and chest coughs associated with tuberculosis [PMID:28228097]. Other reported uses include treating dermatitis and various types of pain [PMID:19111068], as well as gonorrhoea, hypertension, and cancer [PMID:11801378].
Composés actifs
Phytochemical screening has identified alkaloids, flavonoids, phenolic compounds, polyphenols, terpenoids, tannins, coumarins, saponins, phytosterols, gums, mucilage, carbohydrates, amino acids, and proteins [PMID:37111925]. Specific isolated compounds include combrebisbibenzyl, stigmasterol, 3-O-β-D-glucopyranoside of β-sitosterol, mollic acid, oleanolic acid, ursolic acid, arjunglucoside I, arjungenin, bellericagenin B, and combregenin [PMID:38934447]. Other identified compounds include punicalagin (ellagitannin), sericoside, corosolic acid, maslinic acid, and asiatic acid [PMID:11406856, PMID:41446565]. Notably, C. molle is a rich source of long-chain polyprenols (found as free alcohols), comprising about 4% of the dry mass of leaves [PMID:9104508].
Mécanisme d'action
Alkaloid extracts from C. molle inhibit hematopoietic prostaglandin D2 synthase (H-PGDS), an enzyme that catalyzes the conversion of PGH2 to PGD2, which mediates inflammatory responses [PMID:24996417].
Preuves cliniques
Preuve DMalaria (Murine model)
Seed extract (250 mg/kg) showed 63.5% parasite suppression in mice infected with Plasmodium berghei ANKA [PMID:29776448]. Methanolic crude extract and solvent fractions showed chemosuppressive effects ranging from 23.61% to 68% [PMID:33574717]. Stem bark extract also showed significant parasitic suppression [PMID:31793332].
Preuve DBacterial Infections (In vitro)
Extracts showed antibacterial activity against Staphylococcus aureus [PMID:38934447, PMID:37176814] and Streptococcus equi [PMID:38481214]. Methanol extracts presented MIC values ≤ 1.00 mg/ml in screenings of Venda medicinal plants [PMID:17582701].
Preuve DTuberculosis (In vitro)
The acetone fraction of the stem bark caused complete inhibition of Mycobacterium tuberculosis at concentrations higher than 1 mg/mL [PMID:11406856].
Preuve DHIV-1 (In vitro)
Methanol extract of the roots was found to be the most inhibitory on the ribonuclease H (RNase H) activity of HIV-1 reverse transcriptase (IC50 9.7 microg/ml) [PMID:15848024].
Preuve DProtozoal Infections (In vitro)
Acetone fraction of stem bark showed significant activity against extracellular T. b. rhodesiense (IC50 2.19 microg/mL) and trophozoites of P. falciparum (IC50 8.17 microg/mL) [PMID:11746844].
Sécurité et effets indésirables
In a 6-month chronic oral safety study in Wistar rats (doses of 62.5, 125, and 250 mg/kg), no mortality or visible signs of toxicity were recorded [PMID:32248808]. Acute toxicity studies in mice using seed extract at doses of 500, 1000, and 2000 mg/kg showed no signs of toxicity or behavioral changes [PMID:29776448].
Synthèse des preuves
The current evidence consists primarily of in vitro studies and animal models (Level D), demonstrating antibacterial, antimalarial, and antioxidant properties, as well as preliminary safety data in rats and mice.
Sources PubMed
1.PMID: 20606772 (2009) — Cytotoxic activity of selected Nigerian plants. · African journal of traditional, complementary, and alternative medicines : AJTCAM
2.PMID: 38934447 (2024) — Antioxidant and antibacterial effects of a new macrocyclic bis(bibenzyl) ether from Combretum molle (Combretaceae). · Zeitschrift fur Naturforschung. C, Journal of biosciences
3.PMID: 28228097 (2017) — Alkaloid extracts from Combretum zeyheri inhibit the growth of Mycobacterium smegmatis. · BMC complementary and alternative medicine
4.PMID: 37111925 (2023) — Phytochemical Composition of Combretum molle (R. Br. ex G. Don.) Engl. & Diels Leaf and Stem Extracts. · Plants (Basel, Switzerland)
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
Ethanolic extracts of C. molle showed no cytotoxic activity against the HeLa cell line [PMID:20606772].
6.PMID: 29776448 (2018) — Anti-plasmodial activities of Combretum molle (Combretaceae) [Zwoo] seed extract in Swiss albino mice. · BMC research notes
7.PMID: 38481214 (2024) — Invitro antibacterial activity of bark, leaf and root extracts of combretum molle plant against streptococcus equi isolated from clinical cases of strangles in donkeys and horses. · BMC veterinary research
8.PMID: 33574717 (2021) — Antimalarial Activity of Methanolic Extracts and Solvent Fractions of Combretum molle Leaves in Plasmodium berghei Infected Mice. · Journal of experimental pharmacology
9.PMID: 24996417 (2014) — Inhibition of hematopoietic prostaglandin D2 synthase (H-PGDS) by an alkaloid extract from Combretum molle. · BMC complementary and alternative medicine
10.PMID: 35268563 (2022) — Effect of Soil Type: Qualitative and Quantitative Analysis of Phytochemicals in Some Browse Species Leaves Found in Savannah Biome of South Africa. · Molecules (Basel, Switzerland)
11.PMID: 37880735 (2023) — Medicinal plants for treatment of diarrhoeal diseases among under-five children: experience from traditional healers in North-eastern Tanzania. · BMC complementary medicine and therapies
12.PMID: 37176814 (2023) — Antioxidant and Antibacterial Activities of the Leaf and Stem Extracts of Combretum molle (R. Br. ex G. Don.) Engl. & Diels. · Plants (Basel, Switzerland)
13.PMID: 11282442 (2001) — An investigation on the biological activity of Combretum species. · Journal of ethnopharmacology
14.PMID: 11406856 (2001) — Investigations on antimycobacterial activity of some Ethiopian medicinal plants. · Phytotherapy research : PTR
15.PMID: 26122102 (2015) — Antibacterial and antibiotic resistance modifying activity of the extracts from Allanblackia gabonensis, Combretum molle and Gladiolus quartinianus against Gram-negative bacteria including multi-drug resistant phenotypes. · BMC complementary and alternative medicine
16.PMID: 41446565 (2025) — Antioxidant potential of a new macrocyclic bisbibenzyl and other compounds from Combretum molle: in vitro and docking analyses. · Drug target insights
17.PMID: 34276369 (2021) — Pharmacological Assessment of the Antiprotozoal Activity, Cytotoxicity and Genotoxicity of Medicinal Plants Used in the Treatment of Malaria in the Greater Mpigi Region in Uganda. · Frontiers in pharmacology
18.PMID: 31793332 (2019) — Evaluation of Antimalarial Activity of the 80% Methanolic Stem Bark Extract of Combretum molle Against Plasmodium berghei in Mice. · Journal of evidence-based integrative medicine
19.PMID: 32248808 (2020) — Chronic oral safety study of the aqueous extract of Combretum molle twigs on biochemical, haematological and antioxidant parameters of Wistar rats. · BMC complementary medicine and therapies
20.PMID: 11801378 (2002) — Ethnobotanical and antimicrobial investigation on some species of Terminalia and Combretum (Combretaceae) growing in Tanzania. · Journal of ethnopharmacology
21.PMID: 32224196 (2020) — Ethnobotanical study of selected medicinal plants traditionally used in the rural Greater Mpigi region of Uganda. · Journal of ethnopharmacology
22.PMID: 38389077 (2024) — Ethnoveterinary medicinal plants and their utilization by the people of Soro District, Hadiya Zone, southern Ethiopia. · Journal of ethnobiology and ethnomedicine
23.PMID: 33510807 (2021) — A Bibliographic Assessment Using the Degrees of Publication Method: Medicinal Plants from the Rural Greater Mpigi Region (Uganda). · Evidence-based complementary and alternative medicine : eCAM
24.PMID: 19111068 (2008) — Ethnopharmacological survey of six medicinal plants from Mali, West-Africa. · Journal of ethnobiology and ethnomedicine
25.PMID: 9104508 (1996) — The occurrence of long-chain polyprenols in leaves of plants of Combretaceae family. · Acta biochimica Polonica
26.PMID: 20097010 (2010) — In vitro anthelmintic activity of Combretum molle (R. Br. ex G. Don) (Combretaceae) against Haemonchus contortus ova and larvae. · Veterinary parasitology
27.PMID: 15848024 (2005) — Evaluation of selected South African medicinal plants for inhibitory properties against human immunodeficiency virus type 1 reverse transcriptase and integrase. · Journal of ethnopharmacology
28.PMID: 11746844 (2001) — In vitro antiprotozoal activity of extract and compounds from the stem bark of Combretum molle. · Phytotherapy research : PTR